SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5twa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		4 / 7 THR A 166
SER A 161
PHE A 146
LEU D  75
 None
None
None
EDO  D 102 ( 4.5A)
 1.09A 1qcaA-5twaA:
undetectable		 1qcaA-5twaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		5 / 10 PHE A 127
TYR A  33
LEU A 170
VAL A 169
LEU A 174
 EDO  A 308 (-4.2A)
None
None
EDO  A 307 ( 4.1A)
EDO  A 308 (-4.8A)
 1.26A 2w98A-5twaA:
undetectable		 2w98A-5twaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		5 / 12 VAL A  87
ALA A  81
ALA A  80
LEU A  32
VAL D  82
 None
 0.96A 3fc6C-5twaA:
undetectable		 3fc6C-5twaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		4 / 6 VAL D  82
VAL A 136
TRP A 133
PHE A 187
 None
None
B3P  A 309 (-4.3A)
None
 1.45A 3jx4A-5twaD:
undetectable
3jx4B-5twaD:
undetectable		 3jx4A-5twaD:
6.57
3jx4B-5twaD:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		4 / 6 VAL D  82
VAL A 136
TRP A 133
PHE A 187
 None
None
B3P  A 309 (-4.3A)
None
 1.43A 3n61A-5twaD:
undetectable
3n61B-5twaD:
undetectable		 3n61A-5twaD:
6.57
3n61B-5twaD:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		3 / 3 GLY A 158
SER A 161
TRP A 165
 None
 0.71A 4e7cD-5twaA:
undetectable		 4e7cD-5twaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		4 / 4 VAL A 136
ALA A 138
PHE A 127
THR A 126
 None
None
EDO  A 308 (-4.2A)
None
 1.38A 4z4fA-5twaA:
undetectable		 4z4fA-5twaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		4 / 4 VAL A 136
ALA A 138
PHE A 127
THR A 126
 None
None
EDO  A 308 (-4.2A)
None
 1.37A 4z4hA-5twaA:
undetectable		 4z4hA-5twaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		4 / 6 VAL D  82
VAL A 136
TRP A 133
PHE A 187
 None
None
B3P  A 309 (-4.3A)
None
 1.39A 5addA-5twaD:
undetectable
5addB-5twaD:
undetectable		 5addA-5twaD:
6.57
5addB-5twaD:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		4 / 6 VAL D  82
VAL A 136
TRP A 133
PHE A 187
 None
None
B3P  A 309 (-4.3A)
None
 1.47A 5adeA-5twaD:
undetectable
5adeB-5twaD:
undetectable		 5adeA-5twaD:
6.57
5adeB-5twaD:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		3 / 3 ASP A 172
SER A  18
TYR A  22
 None
 0.83A 5glmA-5twaA:
undetectable		 5glmA-5twaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium;
Lubomirskia
baicalensis) 		5 / 10 TYR A 190
MET A  29
ILE A  94
LEU D  75
LEU A 194
 None
None
None
EDO  D 102 ( 4.5A)
None
 1.11A 5ienB-5twaA:
undetectable		 5ienB-5twaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2
(Geodia
cydonium) 		5 / 12 GLU A 118
ILE A 155
VAL A 162
TYR A 149
PHE A 146
 None
 1.37A 5vlmB-5twaA:
undetectable		 5vlmB-5twaA:
21.74