SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5twb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A   9
ILE A 286
GLY A 116
ILE A 117
ILE A   7
 FAD  A 401 ( 4.7A)
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
None
 0.98A 1c6zA-5twbA:
undetectable		 1c6zA-5twbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.02A 1kiaA-5twbA:
2.8		 1kiaA-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.03A 1kiaB-5twbA:
3.2		 1kiaB-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.04A 1kiaC-5twbA:
2.9		 1kiaC-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 GLY A   9
ILE A 286
GLY A 116
ILE A 117
ILE A   7
 FAD  A 401 ( 4.7A)
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
None
 0.96A 1n49B-5twbA:
undetectable		 1n49B-5twbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 GLY A   9
ILE A 286
GLY A 116
ILE A 117
ILE A   7
 FAD  A 401 ( 4.7A)
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
None
 0.95A 1n49C-5twbA:
undetectable		 1n49C-5twbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.04A 1nbhB-5twbA:
2.7		 1nbhB-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.15A 1nbiA-5twbA:
2.8		 1nbiA-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 117
GLY A   8
VAL A  32
ALA A  16
GLY A  38
 FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
None
FAD  A 401 (-3.2A)
 1.15A 1nbiB-5twbA:
2.9		 1nbiB-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 156
ALA A 164
TRP A 163
GLY A 244
SER A 242
 None
 1.11A 1nbiD-5twbA:
undetectable		 1nbiD-5twbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 GLY A   9
ILE A 111
ILE A 286
GLY A 116
ILE A 117
 FAD  A 401 ( 4.7A)
None
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
 0.70A 1sh9B-5twbA:
undetectable		 1sh9B-5twbA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A   9
ILE A 111
ILE A 286
GLY A 116
ILE A 117
 FAD  A 401 ( 4.7A)
None
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
 0.91A 2b60A-5twbA:
undetectable		 2b60A-5twbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 GLY A 303
ALA A  16
GLY A  21
ALA A 108
ILE A 110
 None
 0.97A 2b60B-5twbA:
undetectable		 2b60B-5twbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A   9
ILE A 111
ILE A 286
GLY A 116
ILE A 117
 FAD  A 401 ( 4.7A)
None
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
 0.74A 2hs1B-5twbA:
undetectable		 2hs1B-5twbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A   9
ILE A 286
GLY A 116
ILE A 117
ILE A   7
 FAD  A 401 ( 4.7A)
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
None
 0.91A 2nmyB-5twbA:
undetectable		 2nmyB-5twbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 LEU A  63
ILE A  42
SER A  17
LEU A  29
VAL A  77
 None
FAD  A 401 ( 4.7A)
None
None
None
 1.23A 2po7B-5twbA:
undetectable		 2po7B-5twbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 VAL A  96
LEU A 251
SER A  17
VAL A  83
ILE A 113
 None
FAD  A 401 ( 3.9A)
None
FAD  A 401 (-3.9A)
FAD  A 401 (-3.6A)
 1.08A 3frqA-5twbA:
undetectable		 3frqA-5twbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A 156
ASP A 162
LEU A 161
GLU A 181
VAL A 183
 None
 1.01A 3o7wA-5twbA:
undetectable		 3o7wA-5twbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 TYR A 281
ILE A 110
ILE A 111
VAL A   4
ILE A  86
 None
 1.46A 3p4wA-5twbA:
undetectable		 3p4wA-5twbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 THR A  66
GLY A  13
ALA A  16
ALA A 304
LEU A  29
 None
 1.15A 3p5nA-5twbA:
undetectable		 3p5nA-5twbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 THR A  66
GLY A  13
ALA A  16
ALA A 304
LEU A  29
 None
 1.16A 3p5nB-5twbA:
undetectable		 3p5nB-5twbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A   9
ILE A 286
GLY A 116
ILE A 117
ILE A   7
 FAD  A 401 ( 4.7A)
None
FAD  A 401 (-4.0A)
FAD  A 401 (-4.8A)
None
 0.89A 3tkgD-5twbA:
undetectable		 3tkgD-5twbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ILE A 113
THR A 275
SER A 276
ILE A 277
ILE A 111
 FAD  A 401 (-3.6A)
None
None
None
None
 1.11A 3um5A-5twbA:
undetectable		 3um5A-5twbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ILE A 113
THR A 275
SER A 276
ILE A 277
ILE A 111
 FAD  A 401 (-3.6A)
None
None
None
None
 1.08A 3um5B-5twbA:
undetectable		 3um5B-5twbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 GLU A  97
GLY A 101
TYR A 104
GLU A  81
 None
 1.50A 3w9tA-5twbA:
undetectable		 3w9tA-5twbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 GLU A  97
GLY A 101
TYR A 104
GLU A  81
 None
 1.49A 3w9tC-5twbA:
undetectable		 3w9tC-5twbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 GLU A  97
GLY A 101
TYR A 104
GLU A  81
 None
 1.49A 3w9tD-5twbA:
undetectable		 3w9tD-5twbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 GLU A  97
GLY A 101
TYR A 104
GLU A  81
 None
 1.49A 3w9tG-5twbA:
undetectable		 3w9tG-5twbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 6 VAL A  83
LEU A 251
ILE A 113
VAL A 109
 FAD  A 401 (-3.9A)
FAD  A 401 ( 3.9A)
FAD  A 401 (-3.6A)
None
 0.92A 4a9kA-5twbA:
undetectable		 4a9kA-5twbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 VAL A  83
LEU A 251
ILE A 113
VAL A 109
 FAD  A 401 (-3.9A)
FAD  A 401 ( 3.9A)
FAD  A 401 (-3.6A)
None
 0.82A 4a9kB-5twbA:
undetectable		 4a9kB-5twbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 VAL A  96
ILE A 117
GLY A   8
ILE A  30
ILE A   6
 None
FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
None
None
 0.92A 4iv0A-5twbA:
2.8		 4iv0A-5twbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 280
ALA A 282
ILE A   7
ALA A 306
VAL A  96
 None
 0.94A 4k6iA-5twbA:
undetectable		 4k6iA-5twbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A  42
GLY A  10
GLY A  37
ALA A 112
ASP A 285
 FAD  A 401 ( 4.7A)
FAD  A 401 (-3.4A)
None
None
FAD  A 401 (-2.9A)
 1.03A 4kicB-5twbA:
undetectable		 4kicB-5twbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 VAL A  84
THR A  98
GLU A  97
GLU A 102
 None
 1.17A 4l78A-5twbA:
undetectable		 4l78A-5twbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 VAL A  96
ILE A 117
GLY A   8
ILE A  30
ILE A   6
 None
FAD  A 401 (-4.8A)
FAD  A 401 (-3.2A)
None
None
 0.94A 4mwzB-5twbA:
2.8		 4mwzB-5twbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 6 LEU A  71
TYR A  72
LYS A  74
PRO A  75
 None
 1.01A 4z4gA-5twbA:
undetectable		 4z4gA-5twbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 TYR A 178
GLY A 156
GLY A 157
VAL A 176
ASP A 162
 None
 1.16A 5f8yA-5twbA:
undetectable		 5f8yA-5twbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 TYR A 178
GLY A 156
GLY A 157
VAL A 176
ASP A 162
 None
 1.15A 5f8yA-5twbA:
undetectable		 5f8yA-5twbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 TYR A 178
GLY A 156
GLY A 157
VAL A 176
ASP A 162
 None
 1.17A 5f8yB-5twbA:
undetectable		 5f8yB-5twbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 TYR A 178
GLY A 156
GLY A 157
VAL A 176
ASP A 162
 None
 1.22A 5f8yB-5twbA:
undetectable		 5f8yB-5twbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 7 LEU A  71
TYR A  72
LYS A  74
PRO A  75
 None
 1.00A 5t7bA-5twbA:
undetectable		 5t7bA-5twbA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ILE A 218
LEU A 133
GLY A 127
ILE A 206
LEU A 123
 None
 1.12A 6dwnC-5twbA:
undetectable		 6dwnC-5twbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 ARG A  23
ALA A  20
GLN A 315
ILE A 314
 None
 1.44A 6g9bA-5twbA:
undetectable
6g9bB-5twbA:
undetectable		 6g9bA-5twbA:
11.99
6g9bB-5twbA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ASP A 264
GLY A 284
SER A  12
ALA A  16
ASN A 249
 None
FAD  A 401 (-3.3A)
FAD  A 401 (-4.4A)
None
None
 1.22A 6hu9A-5twbA:
undetectable
6hu9E-5twbA:
undetectable
6hu9I-5twbA:
undetectable		 6hu9A-5twbA:
21.59
6hu9E-5twbA:
20.06
6hu9I-5twbA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5twb FERREDOXIN--NADP
REDUCTASE
(Staphylococcus
aureus) 		4 / 8 HIS A 186
GLY A 185
GLY A 156
LEU A 161
 None
 0.88A 6mdqA-5twbA:
undetectable		 6mdqA-5twbA:
12.32