SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 PHE A 427
THR A 314
VAL A 315
ALA A 422
 None
 0.90A 1fo4B-5twsA:
undetectable		 1fo4B-5twsA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		3 / 3 ASP A 330
ARG A 416
ARG A 323
 MG  A 501 (-2.6A)
NA  A 502 ( 4.9A)
GOA  A 503 (-3.0A)
 1.01A 3k37A-5twsA:
undetectable		 3k37A-5twsA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 5 ARG A 323
ASP A 330
ASP A 332
ASP A 418
 GOA  A 503 (-3.0A)
MG  A 501 (-2.6A)
NA  A 502 (-2.5A)
NA  A 502 (-3.1A)
 1.47A 3naiC-5twsA:
1.8		 3naiC-5twsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		5 / 12 ALA A 159
SER A 209
SER A 210
VAL A 228
ALA A 164
 None
 1.31A 3qxvE-5twsA:
undetectable		 3qxvE-5twsA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		3 / 3 GLN A 242
GLU A 165
LYS A 238
 None
 1.18A 3su9A-5twsA:
undetectable		 3su9A-5twsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 6 LEU A 484
PHE A 440
ALA A 494
THR A 147
 None
 1.00A 3t3zB-5twsA:
undetectable		 3t3zB-5twsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 6 LEU A 484
PHE A 440
ALA A 494
THR A 147
 None
 0.99A 3t3zD-5twsA:
undetectable		 3t3zD-5twsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 6 PHE A 179
GLU A 165
ARG A 175
VAL A 225
 None
 1.48A 5ad8A-5twsA:
undetectable
5ad8B-5twsA:
undetectable		 5ad8A-5twsA:
21.64
5ad8B-5twsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		3 / 3 VAL A 417
VAL A 331
GLN A 299
 None
 0.67A 5qh6A-5twsA:
undetectable		 5qh6A-5twsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 PHE A 179
GLU A 165
ARG A 175
VAL A 225
 None
 1.47A 5unuA-5twsA:
undetectable
5unuB-5twsA:
undetectable		 5unuA-5twsA:
21.64
5unuB-5twsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 PHE A 179
GLU A 165
ARG A 175
VAL A 225
 None
 1.46A 5unwA-5twsA:
undetectable
5unwB-5twsA:
undetectable		 5unwA-5twsA:
21.64
5unwB-5twsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 ARG A 175
VAL A 225
PHE A 179
GLU A 165
 None
 1.37A 5unxA-5twsA:
undetectable
5unxB-5twsA:
undetectable		 5unxA-5twsA:
21.64
5unxB-5twsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 6 PHE A 179
GLU A 165
ARG A 175
VAL A 225
 None
 1.42A 5unxA-5twsA:
undetectable
5unxB-5twsA:
undetectable		 5unxA-5twsA:
21.64
5unxB-5twsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 PHE A 179
GLU A 165
ARG A 175
VAL A 225
 None
 1.45A 5uo6A-5twsA:
undetectable
5uo6B-5twsA:
undetectable		 5uo6A-5twsA:
21.55
5uo6B-5twsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		4 / 7 GLU A 165
TYR A 234
ALA A 251
GLY A 247
 None
None
None
NA  A 508 ( 4.7A)
 1.06A 5uxdA-5twsA:
undetectable		 5uxdA-5twsA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		3 / 3 LEU A 444
LEU A 432
ARG A 492
 None
 0.52A 6fgcA-5twsA:
undetectable		 6fgcA-5twsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens) 		3 / 3 LEU A 444
LEU A 432
ARG A 492
 None
 0.49A 6fgdA-5twsA:
undetectable		 6fgdA-5twsA:
22.47