SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5twx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		4 / 6 THR A 220
VAL A 221
LEU A 225
ALA A 212
 7P7  A4000 ( 4.1A)
None
None
7P7  A4000 ( 3.8A)
 1.01A 2e1qC-5twxA:
undetectable		 2e1qC-5twxA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 GLU A 146
GLN A 151
ARG A 154
 None
 0.82A 2w3bB-5twxA:
undetectable		 2w3bB-5twxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 TYR A 195
ASP A 182
ASP A 204
 None
 0.83A 3r24A-5twxA:
undetectable		 3r24A-5twxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		4 / 7 THR A 220
VAL A 221
LEU A 225
ALA A 212
 7P7  A4000 ( 4.1A)
None
None
7P7  A4000 ( 3.8A)
 1.01A 3uniA-5twxA:
2.1		 3uniA-5twxA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 ASP A 188
GLY A 184
ASP A 182
 None
 0.68A 4xdtA-5twxA:
undetectable		 4xdtA-5twxA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 VAL A 198
LYS A 206
MET A 208
 None
 1.04A 5nknA-5twxA:
undetectable		 5nknA-5twxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 LYS A 202
LYS A 235
SER A 238
 None
 1.34A 5odiA-5twxA:
undetectable		 5odiA-5twxA:
11.27