SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 194
VAL A 153
VAL A 246
LEU A 232
MET A 226
 None
 1.49A 1mx1E-5tx7A:
undetectable		 1mx1E-5tx7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 8 LEU A 109
ALA A 258
LEU A 281
VAL A 246
 None
 0.98A 1sn5C-5tx7A:
undetectable		 1sn5C-5tx7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 ILE A  38
ILE A  39
ALA A  42
LEU A  55
ILE A  89
 None
 1.24A 1xzxX-5tx7A:
undetectable		 1xzxX-5tx7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 7 VAL A  48
ALA A  42
PHE A 308
PRO A  90
 None
 0.99A 2q6oA-5tx7A:
2.7		 2q6oA-5tx7A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 241
LEU A 206
VAL A 204
LEU A 194
PHE A 198
 None
 1.12A 3datA-5tx7A:
undetectable		 3datA-5tx7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 10 VAL A  94
LEU A 297
TYR A  76
GLY A  96
GLY A  98
 None
 1.31A 3ls4H-5tx7A:
undetectable		 3ls4H-5tx7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 10 GLY A   8
LEU A  27
LEU A  49
LEU A  11
ILE A  21
 None
 1.21A 3wdmB-5tx7A:
undetectable		 3wdmB-5tx7A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		5 / 9 GLY A   8
LEU A  27
LEU A  49
LEU A  11
ILE A  21
 None
 1.19A 3wdmC-5tx7A:
undetectable		 3wdmC-5tx7A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 7 THR A  10
GLY A   8
VAL A  29
PRO A  31
 None
 0.83A 4forA-5tx7A:
undetectable		 4forA-5tx7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 5 THR A  10
GLY A   8
VAL A  29
PRO A  31
 None
 0.84A 4grkA-5tx7A:
undetectable		 4grkA-5tx7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 5 VAL A 203
LEU A 110
ILE A 233
LEU A 232
 None
 0.84A 4mghA-5tx7A:
3.7		 4mghA-5tx7A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 5 LEU A 109
ALA A 258
LEU A 281
VAL A 246
 None
 1.01A 5cr1A-5tx7A:
undetectable		 5cr1A-5tx7A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 321
LEU A 322
GLY A  85
VAL A  81
 None
 0.70A 5m8rC-5tx7A:
undetectable		 5m8rC-5tx7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 5 ASP A 139
GLU A 143
ARG A 115
THR A 141
 None
 1.44A 5uxcA-5tx7A:
undetectable		 5uxcA-5tx7A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Desulfovibrio
vulgaris) 		4 / 8 ILE A  38
LEU A  63
LEU A  87
ALA A  84
 None
 0.66A 5y7pE-5tx7A:
undetectable		 5y7pE-5tx7A:
19.23