SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 10 ALA A 587
LEU A 598
ALA A 595
PHE A 535
ILE A 538
 None
 1.04A 1g5yC-5txeA:
undetectable		 1g5yC-5txeA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 8 ASN A 391
LEU A 394
ARG A 396
TYR A 397
 None
 0.72A 1hk3A-5txeA:
undetectable		 1hk3A-5txeA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 ARG A  75
ARG A  87
ARG A 445
 None
 1.03A 1l7fA-5txeA:
undetectable		 1l7fA-5txeA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 ARG A  75
ARG A  87
ARG A 445
 None
 1.02A 1l7hA-5txeA:
5.1		 1l7hA-5txeA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 TRP A 586
PHE A 585
TRP A 493
 None
 1.32A 1r15C-5txeA:
2.8		 1r15C-5txeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 TRP A 586
PHE A 585
TRP A 493
 None
 1.32A 1r15F-5txeA:
2.9		 1r15F-5txeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 TRP A 586
PHE A 585
TRP A 493
 None
 1.33A 1r15G-5txeA:
2.7		 1r15G-5txeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 TRP A 586
PHE A 585
TRP A 493
 None
 1.31A 1r15H-5txeA:
undetectable		 1r15H-5txeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 PHE A 543
THR A 548
LEU A 602
LEU A 500
PHE A 591
 None
 1.08A 2jn3A-5txeA:
3.2		 2jn3A-5txeA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 ALA A  54
SER A 440
PHE A 416
GLY A 349
THR A 348
 None
 1.17A 2zifA-5txeA:
2.3		 2zifA-5txeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 ALA A  54
SER A 440
PHE A 416
GLY A 349
THR A 348
 None
 1.13A 2zifB-5txeA:
2.1		 2zifB-5txeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 7 VAL A 415
SER A 417
THR A 502
LEU A 503
 None
 0.85A 3arrA-5txeA:
undetectable		 3arrA-5txeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 ASN A 127
ASP A  48
ARG A 321
 None
 0.91A 3k13A-5txeA:
2.2		 3k13A-5txeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 LEU A  43
ARG A  45
PRO A 456
GLY A 446
LEU A 647
 None
 1.33A 3okxA-5txeA:
undetectable		 3okxA-5txeA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 7 ASN A 127
ALA A 126
ALA A  54
ARG A 372
 None
 0.99A 3twpA-5txeA:
undetectable		 3twpA-5txeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 7 ASN A 127
ALA A 126
ALA A  54
ARG A 372
 None
 1.00A 3twpB-5txeA:
undetectable		 3twpB-5txeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 7 ASN A 127
ALA A 126
ALA A  54
ARG A 372
 None
 0.99A 3twpC-5txeA:
undetectable		 3twpC-5txeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 7 GLU A 504
ASP A 505
ASN A 409
ILE A 499
 None
 1.19A 4ii8A-5txeA:
undetectable		 4ii8A-5txeA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 GLY A 461
ALA A 460
ILE A 454
THR A 653
ILE A 654
 None
 0.99A 4njvA-5txeA:
undetectable		 4njvA-5txeA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		6 / 12 VAL A 402
LEU A 369
VAL A 464
ILE A 454
VAL A  42
LEU A 394
 None
 1.41A 4y8wC-5txeA:
undetectable		 4y8wC-5txeA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 ARG A 646
PRO A 643
ASN A  84
 None
 1.04A 5jwaA-5txeA:
undetectable
5jwaH-5txeA:
undetectable		 5jwaA-5txeA:
19.62
5jwaH-5txeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 ALA A 527
GLY A 529
ASN A 498
LEU A 503
GLU A 504
 None
 0.95A 5nwuA-5txeA:
undetectable		 5nwuA-5txeA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 6 ARG A 133
ALA A  71
PRO A 132
GLU A 355
 None
 1.35A 5odqA-5txeA:
2.5		 5odqA-5txeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 8 SER A 469
THR A 532
PHE A 467
ASP A 505
 None
 1.11A 5t8sB-5txeA:
undetectable		 5t8sB-5txeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 5 ARG A 471
TYR A 476
GLU A 299
ASP A 297
 None
 1.48A 5yf0A-5txeA:
undetectable		 5yf0A-5txeA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 4 ARG A 471
TYR A 476
GLU A 299
ASP A 297
 None
 1.45A 5yf0B-5txeA:
0.0		 5yf0B-5txeA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		3 / 3 MET A 307
ASP A 257
ARG A 272
 None
 1.09A 5z6jA-5txeA:
undetectable		 5z6jA-5txeA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 PRO A 371
LEU A 394
VAL A  42
PRO A 423
LEU A 399
 None
 1.11A 6eliA-5txeA:
undetectable		 6eliA-5txeA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5txe ATXE2
(Asticcacaulis
excentricus) 		5 / 12 VAL A 233
ASP A 180
ASN A 182
ARG A 155
GLY A 239
 None
 1.03A 6gnfC-5txeA:
undetectable		 6gnfC-5txeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5txe ATXE2
(Asticcacaulis
excentricus) 		4 / 6 VAL A  44
ASN A 452
PRO A 453
GLU A 451
 None
 1.25A 6h7uA-5txeA:
undetectable		 6h7uA-5txeA:
21.28