SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 281
TYR A 273
ILE A 266
LEU A 285
 None
 0.81A 1fslB-5txfA:
undetectable		 1fslB-5txfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.07A 1p7lC-5txfA:
undetectable		 1p7lC-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.07A 1p7lD-5txfA:
undetectable		 1p7lD-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.06A 1rg9A-5txfA:
undetectable		 1rg9A-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.03A 1rg9B-5txfA:
undetectable		 1rg9B-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.02A 1rg9C-5txfA:
undetectable		 1rg9C-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 218
SER A 216
THR A 353
ASP A 346
 None
 1.01A 1rg9D-5txfA:
undetectable		 1rg9D-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 11 ASN A  92
ILE A  98
THR A  79
LEU A  36
GLN A 152
 None
 1.40A 1tw4A-5txfA:
undetectable		 1tw4A-5txfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 7 ILE A 231
PHE A  67
LEU A  64
ASN A 228
ILE A 245
 None
 1.37A 1yc2E-5txfA:
2.7		 1yc2E-5txfA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 11 GLY A 183
PRO A  29
ASN A  34
VAL A 100
TYR A 144
 None
 1.32A 2fl5A-5txfA:
undetectable
2fl5B-5txfA:
undetectable
2fl5F-5txfA:
undetectable		 2fl5A-5txfA:
17.54
2fl5B-5txfA:
18.34
2fl5F-5txfA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 7 THR A 347
ASP A 345
VAL A 381
LEU A  32
 None
 1.00A 2hdnE-5txfA:
undetectable
2hdnF-5txfA:
2.3
2hdnH-5txfA:
undetectable		 2hdnE-5txfA:
7.47
2hdnF-5txfA:
23.64
2hdnH-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 7 VAL A 381
LEU A  32
THR A 347
ASP A 345
 None
 0.99A 2hdnF-5txfA:
2.3
2hdnG-5txfA:
undetectable
2hdnH-5txfA:
undetectable		 2hdnF-5txfA:
23.64
2hdnG-5txfA:
7.47
2hdnH-5txfA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ALA A 283
ASP A 284
GLU A 288
ARG A  85
 None
 1.46A 2ouzA-5txfA:
undetectable		 2ouzA-5txfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.28A 2xdcC-5txfA:
undetectable
2xdcD-5txfA:
undetectable		 2xdcC-5txfA:
2.78
2xdcD-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.24A 2xdcE-5txfA:
undetectable
2xdcF-5txfA:
undetectable		 2xdcE-5txfA:
2.78
2xdcF-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.25A 2y5mE-5txfA:
undetectable
2y5mF-5txfA:
undetectable		 2y5mE-5txfA:
2.78
2y5mF-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.25A 2y6nC-5txfA:
undetectable
2y6nD-5txfA:
undetectable		 2y6nC-5txfA:
2.78
2y6nD-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.27A 2y6nE-5txfA:
undetectable
2y6nF-5txfA:
undetectable		 2y6nE-5txfA:
2.78
2y6nF-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 GLY A 205
VAL A 309
LEU A 191
TRP A 198
 None
 0.92A 3bgdB-5txfA:
undetectable		 3bgdB-5txfA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 VAL A 134
VAL A 129
GLY A 132
ARG A 135
 None
 0.95A 3bjwA-5txfA:
undetectable		 3bjwA-5txfA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 301
ARG A 193
SER A 249
GLY A 151
 None
 0.91A 3hcnA-5txfA:
3.2		 3hcnA-5txfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LEU A 301
ARG A 193
SER A 249
GLY A 151
 None
 0.88A 3hcrA-5txfA:
3.4		 3hcrA-5txfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 301
ARG A 193
SER A 249
GLY A 151
 None
 0.93A 3hcrB-5txfA:
3.2		 3hcrB-5txfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 PRO A 336
PHE A 331
ALA A 224
 None
 0.69A 3itaD-5txfA:
undetectable		 3itaD-5txfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  33
SER A 181
ILE A 231
ARG A 147
LEU A  32
 None
 1.35A 3iv6C-5txfA:
undetectable		 3iv6C-5txfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 11 GLY A 104
ASN A  34
LEU A  27
LEU A 160
LEU A 163
 None
 1.38A 3ndvA-5txfA:
undetectable
3ndvB-5txfA:
undetectable		 3ndvA-5txfA:
23.18
3ndvB-5txfA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 160
LEU A 163
GLY A 104
ASN A  34
LEU A  27
 None
 1.38A 3ndvC-5txfA:
undetectable
3ndvD-5txfA:
undetectable		 3ndvC-5txfA:
23.18
3ndvD-5txfA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.38A 3zq8A-5txfA:
undetectable
3zq8B-5txfA:
undetectable		 3zq8A-5txfA:
2.78
3zq8B-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		3 / 3 LYS A 173
ARG A 140
VAL A 139
 None
 0.82A 4x3uA-5txfA:
undetectable
4x3uB-5txfA:
undetectable		 4x3uA-5txfA:
11.17
4x3uB-5txfA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 191
GLY A 308
GLN A 363
PHE A 206
LEU A 301
 None
 1.34A 5uc3B-5txfA:
undetectable		 5uc3B-5txfA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens) 		4 / 8 VAL A 264
PRO A 254
THR A 268
TYR A 327
 None
 0.82A 6cduG-5txfA:
undetectable
6cduH-5txfA:
undetectable		 6cduG-5txfA:
20.59
6cduH-5txfA:
20.59