SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 LEU A 774
SER A 587
ALA A 791
TYR A 780
THR A 576
 None
 1.09A 2japA-5txkA:
undetectable		 2japA-5txkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 LEU A 774
SER A 587
ALA A 791
TYR A 780
THR A 576
 None
 1.10A 2japB-5txkA:
undetectable		 2japB-5txkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 LEU A 774
SER A 587
ALA A 791
TYR A 780
THR A 576
 None
 1.08A 2japC-5txkA:
undetectable		 2japC-5txkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 LEU A 774
SER A 587
ALA A 791
TYR A 780
THR A 576
 None
 1.07A 2japD-5txkA:
undetectable		 2japD-5txkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 TYR A 524
LEU A 532
LEU A 484
ILE A 455
PHE A 465
 None
 1.28A 2weyA-5txkA:
undetectable		 2weyA-5txkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		4 / 5 VAL A 850
TYR A 866
VAL A 909
ASP A 916
 None
 0.92A 2x45A-5txkA:
undetectable		 2x45A-5txkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		4 / 5 VAL A 850
TYR A 866
VAL A 909
ASP A 916
 None
 0.87A 2x45C-5txkA:
undetectable		 2x45C-5txkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 12 LEU A 835
LEU A 804
LEU A 596
ASN A 766
LEU A 809
 None
 0.86A 3r9cA-5txkA:
undetectable		 3r9cA-5txkA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		4 / 8 TYR A 527
LEU A 480
LEU A 532
THR A 564
 None
 1.02A 5hs6A-5txkA:
undetectable		 5hs6A-5txkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		4 / 5 PHE A 513
SER A 514
ASN A 453
ASP A 895
 None
 1.33A 5kpcA-5txkA:
undetectable		 5kpcA-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 9 SER A 828
PRO A 830
TYR A 923
LEU A 833
SER A 758
 None
 1.34A 5l1fB-5txkA:
0.7		 5l1fB-5txkA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		3 / 3 ASN A 585
TYR A 780
CYH A 785
 None
None
ZN  A1006 (-2.3A)
 1.03A 5lsuB-5txkA:
undetectable		 5lsuB-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 8 GLY A 442
LEU A 443
ASN A 453
GLN A 457
PHE A 893
 None
 0.35A 5xu8A-5txkA:
32.7		 5xu8A-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 8 GLY A 442
LEU A 443
SER A 454
GLN A 457
PHE A 893
 None
 0.68A 5xu8A-5txkA:
32.7		 5xu8A-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		4 / 6 LEU A 472
GLN A 478
LEU A 480
LEU A 532
 None
 1.13A 5yvnA-5txkA:
undetectable		 5yvnA-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens) 		5 / 10 PHE A 893
MET A 461
ALA A 458
THR A 594
VAL A 851
 None
None
None
EDO  A1005 (-4.6A)
None
 1.22A 6hu9C-5txkA:
undetectable		 6hu9C-5txkA:
undetectable