SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 GLY B 343
LEU B 335
THR B 334
VAL B 373
 None
None
PLP  B 605 (-3.6A)
None
 1.09A 1ekjF-5txrB:
undetectable
1ekjG-5txrB:
undetectable		 1ekjF-5txrB:
undetectable
1ekjG-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.32A 1eqbA-5txrB:
23.3
1eqbB-5txrB:
24.4		 1eqbA-5txrB:
undetectable
1eqbB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.33A 1eqbA-5txrB:
23.3
1eqbB-5txrB:
24.4		 1eqbA-5txrB:
undetectable
1eqbB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.32A 1eqbC-5txrB:
24.3
1eqbD-5txrB:
24.2		 1eqbC-5txrB:
undetectable
1eqbD-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.33A 1eqbC-5txrB:
24.3
1eqbD-5txrB:
24.2		 1eqbC-5txrB:
undetectable
1eqbD-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 SER B 393
THR B 392
LEU B 288
TRP B 516
 None
 1.30A 1mxdA-5txrB:
undetectable		 1mxdA-5txrB:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 331
ALA B 347
ALA B 348
ALA B 168
ILE B 264
 None
 1.05A 2aclC-5txrB:
undetectable		 2aclC-5txrB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 331
ALA B 347
ALA B 348
ALA B 168
ILE B 264
 None
 1.07A 2aclE-5txrB:
undetectable		 2aclE-5txrB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 333
GLY B 344
GLY B 336
VAL B 346
ILE B 331
 None
PLP  B 605 ( 4.8A)
None
None
None
 1.06A 2b25A-5txrB:
2.4		 2b25A-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ARG B 382
GLY B 293
ALA B 294
ILE B 331
GLY B 333
 None
 0.87A 2b60A-5txrB:
undetectable		 2b60A-5txrB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 THR B 334
LEU B 167
HIS B 171
SER B 338
LEU B 163
 PLP  B 605 (-3.6A)
None
None
None
None
 1.40A 2idkA-5txrB:
2.3
2idkB-5txrB:
2.3
2idkC-5txrB:
2.2
2idkD-5txrB:
undetectable		 2idkA-5txrB:
undetectable
2idkB-5txrB:
undetectable
2idkC-5txrB:
undetectable
2idkD-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 HIS B 209
HIS B 284
LYS B 337
ARG B 461
 PLP  B 605 (-3.4A)
PLP  B 605 (-3.6A)
PLP  B 605 (-2.9A)
None
 1.23A 2vmyA-5txrB:
25.3
2vmyB-5txrB:
24.9		 2vmyA-5txrB:
undetectable
2vmyB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ALA B 479
LEU B 437
ILE B 410
ILE B 424
PHE B 484
 None
 1.19A 2w9sC-5txrB:
undetectable		 2w9sC-5txrB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 331
ALA B 347
ALA B 348
ALA B 168
ILE B 264
 None
 0.92A 3falA-5txrB:
undetectable		 3falA-5txrB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 GLY B 295
GLY B 290
GLU B 298
ALA B 285
 None
 0.87A 3fpjB-5txrB:
2.3		 3fpjB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 CYH B 119
THR B 463
THR B 465
ILE B 438
LEU B 476
 None
 1.33A 3gwxA-5txrB:
undetectable		 3gwxA-5txrB:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLN B 236
LEU B 234
GLU B 235
LEU B 270
 None
 0.86A 3h5gA-5txrB:
undetectable
3h5gC-5txrB:
undetectable		 3h5gA-5txrB:
undetectable
3h5gC-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 267
ALA B 271
PHE B 251
ILE B 331
ILE B 264
 None
 1.20A 3qgtB-5txrB:
2.1		 3qgtB-5txrB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 381
LEU B 170
ALA B 176
ALA B 347
 None
 0.88A 3r9tB-5txrB:
undetectable		 3r9tB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1227_0
(THAUMATIN-LIKE
PROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 THR B 392
ARG B 391
ASN B 525
ILE B 388
 None
 1.32A 3zs3A-5txrB:
0.0		 3zs3A-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 248
THR B 332
LEU B 277
VAL B 346
 None
 0.88A 4ik6B-5txrB:
undetectable		 4ik6B-5txrB:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 155
ASN B 157
ILE B 153
PHE B 363
ARG B 357
 None
 1.42A 4kosA-5txrB:
undetectable		 4kosA-5txrB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 TYR B 345
LEU B 170
LEU B 126
ALA B 380
GLY B 287
 None
 1.35A 4rn6A-5txrB:
undetectable		 4rn6A-5txrB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 ALA B 377
SER B 341
ALA B 375
ALA B 135
ALA B 380
 None
 1.28A 4twdA-5txrB:
undetectable
4twdB-5txrB:
undetectable
4twdC-5txrB:
undetectable
4twdD-5txrB:
undetectable
4twdE-5txrB:
undetectable		 4twdA-5txrB:
12.04
4twdB-5txrB:
12.04
4twdC-5txrB:
12.04
4twdD-5txrB:
12.04
4twdE-5txrB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 THR B 465
THR B 463
LYS B 337
GLY B 287
ALA B 285
 None
None
PLP  B 605 (-2.9A)
None
None
 1.23A 4ypmA-5txrB:
undetectable		 4ypmA-5txrB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ALA B 380
TYR B 383
PRO B 466
 None
FMT  B 604 (-4.7A)
FMT  B 603 ( 4.8A)
 0.62A 4zdyA-5txrB:
undetectable		 4zdyA-5txrB:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 310
ILE B 536
ARG B 382
GLU B 166
 None
 1.20A 4zzcE-5txrB:
undetectable		 4zzcE-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 THR B 368
THR B 367
PHE B 365
 None
 0.92A 5cxvA-5txrB:
undetectable		 5cxvA-5txrB:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 GLN B 395
THR B 392
LEU B 126
LEU B 124
 None
 1.31A 5m5kB-5txrB:
2.4		 5m5kB-5txrB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 267
VAL B 328
VAL B 189
LEU B 190
ILE B 202
 None
 0.85A 5mugA-5txrB:
undetectable		 5mugA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 343
ILE B 388
GLY B 290
LEU B 170
THR B 334
 None
None
None
None
PLP  B 605 (-3.6A)
 1.16A 6e8qA-5txrB:
undetectable		 6e8qA-5txrB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 SER B 349
ALA B 348
THR B 278
LEU B 248
ALA B 271
 None
 1.35A 6efnA-5txrB:
1.9		 6efnA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 SER B 349
ALA B 348
THR B 278
LEU B 248
ALA B 276
 None
 1.13A 6efnA-5txrB:
1.9		 6efnA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 472
THR B 469
THR B 465
GLY B 467
 None
None
None
FMT  B 603 ( 3.9A)
 0.95A 6gtqA-5txrB:
undetectable		 6gtqA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 GLY B 362
PHE B 363
VAL B 189
SER B 180
 None
 1.05A 6hu9S-5txrB:
undetectable
6hu9q-5txrB:
undetectable		 6hu9S-5txrB:
undetectable
6hu9q-5txrB:
undetectable