SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		4 / 6 VAL A 285
VAL A 290
ILE A  99
ARG A 279
 None
 1.06A 1iepA-5txvA:
undetectable		 1iepA-5txvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		5 / 12 LEU A 399
LEU A 402
ILE A 376
ILE A 373
THR A 419
 None
 0.90A 2bdmA-5txvA:
undetectable		 2bdmA-5txvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		4 / 8 ILE A 351
SER A 350
LEU A 399
GLU A 400
 None
 0.97A 2cdqA-5txvA:
undetectable		 2cdqA-5txvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		3 / 3 HIS A  16
ARG A  69
GLU A  12
 None
 0.96A 3qf1A-5txvA:
undetectable		 3qf1A-5txvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		3 / 3 LYS A 314
PRO A 315
SER A 316
 None
 0.49A 4k50I-5txvA:
undetectable		 4k50I-5txvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		4 / 6 ASP A  21
ASN A  22
ALA A  23
ASP A  14
 None
 1.15A 4mdbA-5txvA:
undetectable		 4mdbA-5txvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		6 / 12 ILE A 252
GLY A 251
ALA A  71
ILE A  66
ALA A  67
VAL A  27
 None
 1.45A 5n0tB-5txvA:
1.6		 5n0tB-5txvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		5 / 12 ALA A 422
GLY A 372
GLU A 341
GLU A 346
LEU A 344
 None
 1.21A 5nwuA-5txvA:
undetectable		 5nwuA-5txvA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		5 / 12 LEU A 326
PHE A 254
GLY A 251
ILE A 258
ALA A  83
 None
 0.88A 5veuH-5txvA:
undetectable		 5veuH-5txvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		4 / 7 GLN A  20
GLY A  62
ILE A 343
GLN A 354
 None
ADP  A 501 (-3.2A)
ADP  A 501 ( 4.5A)
None
 1.04A 5vlmC-5txvA:
undetectable		 5vlmC-5txvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU
(Escherichia
coli) 		4 / 8 GLN A  20
GLY A  62
ILE A 343
GLN A 354
 None
ADP  A 501 (-3.2A)
ADP  A 501 ( 4.5A)
None
 0.89A 5vlmD-5txvA:
undetectable		 5vlmD-5txvA:
19.37