SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5txw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		4 / 7 GLY A  10
HIS A  44
ASP A  13
PRO A 151
 None
 1.12A 1th6A-5txwA:
undetectable		 1th6A-5txwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		4 / 7 GLY A  10
HIS A  44
ASP A  13
PRO A 151
 None
 1.14A 2armA-5txwA:
undetectable		 2armA-5txwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 9 LEU A 165
ALA A  97
LEU A  67
GLU A  15
LEU A 154
 None
None
None
OCS  A 100 ( 2.4A)
None
 1.44A 2azqA-5txwA:
undetectable		 2azqA-5txwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 12 VAL A  76
GLY A  70
GLY A  69
ILE A  99
ILE A 105
 None
OCS  A 100 ( 3.7A)
OCS  A 100 ( 3.0A)
OCS  A 100 ( 3.7A)
None
 0.98A 2r5pA-5txwA:
undetectable		 2r5pA-5txwA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 12 VAL A  76
GLY A  70
GLY A  69
ILE A  99
ILE A 105
 None
OCS  A 100 ( 3.7A)
OCS  A 100 ( 3.0A)
OCS  A 100 ( 3.7A)
None
 0.98A 2r5pC-5txwA:
undetectable		 2r5pC-5txwA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 12 HIS A 101
THR A 122
VAL A 127
ILE A 107
PRO A 103
 OCS  A 100 ( 3.8A)
None
None
None
OCS  A 100 ( 4.3A)
 1.25A 3kpbC-5txwA:
undetectable		 3kpbC-5txwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		4 / 6 VAL A 135
VAL A 127
TRP A 134
GLU A 133
 None
 1.42A 3n61A-5txwA:
undetectable
3n61B-5txwA:
undetectable		 3n61A-5txwA:
18.29
3n61B-5txwA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		4 / 5 ASP A 125
ARG A 124
TRP A 134
ILE A 121
 None
 1.48A 3sanA-5txwA:
undetectable		 3sanA-5txwA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		4 / 5 ASP A 125
ARG A 124
TRP A 134
ILE A 121
 None
 1.49A 3sanB-5txwA:
undetectable		 3sanB-5txwA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 12 GLY A 102
GLN A 104
PHE A   5
GLU A  74
ALA A  72
 OCS  A 100 ( 4.5A)
None
None
None
None
 1.30A 3t7sD-5txwA:
undetectable		 3t7sD-5txwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 10 GLU A  15
GLY A  69
GLY A  70
ILE A  99
PRO A 103
 OCS  A 100 ( 2.4A)
OCS  A 100 ( 3.0A)
OCS  A 100 ( 3.7A)
OCS  A 100 ( 3.7A)
OCS  A 100 ( 4.3A)
 0.41A 6e5zA-5txwA:
26.3		 6e5zA-5txwA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 11 LEU A 165
ALA A  64
PHE A   5
ALA A  97
PHE A 161
 None
 1.33A 6qgbA-5txwA:
undetectable		 6qgbA-5txwA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5txw PEPTIDASE
(Thermococcus
thioreducens) 		5 / 11 LEU A 165
ALA A  64
PHE A   5
ALA A  97
PHE A 161
 None
 1.33A 6qgbE-5txwA:
undetectable		 6qgbE-5txwA:
14.68