SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ty0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		3 / 3 ASN A 129
TRP A 125
GLN A 127
 None
 1.37A 1xoqA-5ty0A:
undetectable		 1xoqA-5ty0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		4 / 4 PRO A 261
LEU A 167
ILE A 184
ARG A 217
 None
 1.30A 4f4dA-5ty0A:
undetectable		 4f4dA-5ty0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		3 / 3 LEU A   5
ARG A  81
MET A 362
 None
 0.88A 4m11C-5ty0A:
undetectable		 4m11C-5ty0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		5 / 9 SER A 100
ALA A 107
VAL A 124
ALA A 128
VAL A  97
 None
 1.06A 6bklA-5ty0A:
undetectable
6bklB-5ty0A:
undetectable
6bklC-5ty0A:
undetectable
6bklD-5ty0A:
undetectable		 6bklA-5ty0A:
5.23
6bklB-5ty0A:
5.23
6bklC-5ty0A:
5.23
6bklD-5ty0A:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		4 / 6 VAL A 180
LEU A 284
ARG A 135
PRO A 261
 None
 1.20A 6brdB-5ty0A:
undetectable		 6brdB-5ty0A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5ty0 ELONGATION FACTOR G
(Legionella
pneumophila) 		4 / 6 VAL A 349
LYS A 350
VAL A 387
THR A 388
 None
 1.14A 6f32B-5ty0A:
undetectable		 6f32B-5ty0A:
23.77