SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 5tz6 CURJ
(Moorea
producens) 		5 / 12 PHE A1232
GLY A1234
PHE A 978
ASP A1156
ALA A 989
 None
None
7OD  A1301 (-4.5A)
7OD  A1301 (-2.1A)
None
 1.32A 1e3vA-5tz6A:
1.1		 1e3vA-5tz6A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 5tz6 CURJ
(Moorea
producens) 		5 / 11 PHE A1232
GLY A1234
PHE A 978
ASP A1156
ALA A 989
 None
None
7OD  A1301 (-4.5A)
7OD  A1301 (-2.1A)
None
 1.30A 1e3vB-5tz6A:
undetectable		 1e3vB-5tz6A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5tz6 CURJ
(Moorea
producens) 		5 / 9 PHE A1119
GLY A1116
ILE A 979
ALA A 976
VAL A 984
 None
 1.35A 2drdA-5tz6A:
undetectable		 2drdA-5tz6A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5tz6 CURJ
(Moorea
producens) 		4 / 8 ILE A1163
PRO A1239
ASN A1238
GLY A1234
 7OD  A1301 ( 4.9A)
7OD  A1301 ( 4.7A)
None
None
 0.82A 3em0B-5tz6A:
2.4		 3em0B-5tz6A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5tz6 CURJ
(Moorea
producens) 		3 / 3 PHE A 974
SER A 993
SER A 990
 None
 0.65A 3ufgB-5tz6A:
undetectable		 3ufgB-5tz6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5tz6 CURJ
(Moorea
producens) 		3 / 3 PRO A 973
LEU A 972
HIS A 946
 None
 0.70A 4pevA-5tz6A:
undetectable		 4pevA-5tz6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5tz6 CURJ
(Moorea
producens) 		5 / 12 ASP A1100
ARG A1120
ILE A1104
ASP A1156
ILE A1163
 None
None
None
7OD  A1301 (-2.1A)
7OD  A1301 ( 4.9A)
 1.30A 4uroA-5tz6A:
undetectable		 4uroA-5tz6A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5tz6 CURJ
(Moorea
producens) 		4 / 5 LEU A 994
PHE A1042
ILE A 992
ILE A1013
 None
 1.02A 5dzk4-5tz6A:
undetectable
5dzkg-5tz6A:
undetectable
5dzkm-5tz6A:
undetectable
5dzkn-5tz6A:
undetectable		 5dzk4-5tz6A:
3.45
5dzkg-5tz6A:
20.13
5dzkm-5tz6A:
22.76
5dzkn-5tz6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5tz6 CURJ
(Moorea
producens) 		4 / 5 ILE A 949
LEU A 975
HIS A1071
VAL A1044
 None
 1.18A 5jmnB-5tz6A:
undetectable		 5jmnB-5tz6A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5tz6 CURJ
(Moorea
producens) 		4 / 7 LEU A 994
ALA A 997
ALA A 998
THR A1002
 None
 0.81A 6a7jA-5tz6A:
undetectable		 6a7jA-5tz6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5tz6 CURJ
(Moorea
producens) 		4 / 7 VAL A 984
LEU A1150
PHE A 967
LEU A 948
 None
 1.03A 6aycA-5tz6A:
undetectable		 6aycA-5tz6A:
12.54