SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  20
ASN A  21
LEU A  23
ALA A  24
LEU A  59
 None
 0.70A 2aa6A-5tz8A:
undetectable		 2aa6A-5tz8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 7 LEU A 472
THR A 473
PRO A 474
GLY A 514
 None
 1.04A 2ddwB-5tz8A:
undetectable		 2ddwB-5tz8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 0.98A 2h77A-5tz8A:
undetectable		 2h77A-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 2h79A-5tz8A:
undetectable		 2h79A-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 VAL A   5
LEU A  19
SER A  22
VAL A   7
ILE A  16
 None
 1.29A 3frqA-5tz8A:
undetectable		 3frqA-5tz8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.07A 3gwsX-5tz8A:
undetectable		 3gwsX-5tz8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 4 PRO A 474
THR A 473
GLY A 510
THR A 509
 None
 0.93A 3ib1A-5tz8A:
undetectable		 3ib1A-5tz8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 5 PHE A 517
ILE A 367
MET A 567
ASN A 563
 None
 1.37A 3octA-5tz8A:
undetectable		 3octA-5tz8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 7 GLN A 537
GLU A 458
PHE A 362
PRO A 474
 None
 1.08A 3ql6A-5tz8A:
undetectable		 3ql6A-5tz8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 4 TYR A 222
TYR A 312
GLU A 316
GLY A 261
 None
 1.31A 3reqA-5tz8A:
0.8		 3reqA-5tz8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 11 ASN A 335
ILE A 329
ASP A 349
GLY A 347
VAL A 315
 None
 1.09A 3rukD-5tz8A:
undetectable		 3rukD-5tz8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 7 GLU A 443
GLU A 434
PHE A 432
TYR A 399
 None
 1.03A 4a97A-5tz8A:
2.4		 4a97A-5tz8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 5 GLU A 443
GLU A 434
PHE A 432
TYR A 399
 None
 1.03A 4a97J-5tz8A:
undetectable		 4a97J-5tz8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 SER A  92
ASP A  93
THR A  17
ILE A  16
 None
 1.07A 4acbC-5tz8A:
undetectable		 4acbC-5tz8A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 SER A  92
ASP A  94
THR A  17
ILE A  16
 None
 1.00A 4acbC-5tz8A:
undetectable		 4acbC-5tz8A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 5 VAL A 289
ARG A 288
GLU A 239
LEU A 233
 None
 1.29A 4hojA-5tz8A:
undetectable		 4hojA-5tz8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 4lnwA-5tz8A:
undetectable		 4lnwA-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 4lnxA-5tz8A:
undetectable		 4lnxA-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		3 / 3 MET A 225
ASP A 178
PHE A 181
 None
 0.96A 4xeyA-5tz8A:
undetectable		 4xeyA-5tz8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		3 / 3 MET A 225
ASP A 178
PHE A 181
 None
 0.93A 4xeyB-5tz8A:
undetectable		 4xeyB-5tz8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  20
LEU A  23
ALA A  24
LEU A  59
ILE A  49
 None
 0.97A 5toaA-5tz8A:
undetectable		 5toaA-5tz8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5tz8 GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLN A 283
GLU A 287
HIS A 302
ALA A 306
 None
 1.33A 6f6jC-5tz8A:
undetectable
6f6jD-5tz8A:
undetectable		 6f6jC-5tz8A:
21.06
6f6jD-5tz8A:
21.06