SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		4 / 6 GLY A 278
ASP A 279
GLY A 271
SER A 276
 None
 0.98A 1eswA-5tzbA:
undetectable		 1eswA-5tzbA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		3 / 3 VAL A 319
ALA A 316
HIS A 313
 None
 0.79A 1q23L-5tzbA:
undetectable		 1q23L-5tzbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 THR A  48
GLY A 164
ILE A 240
LEU A 266
LEU A 197
 None
 1.21A 1r30A-5tzbA:
undetectable		 1r30A-5tzbA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 THR A  48
GLY A 164
ILE A 240
LEU A 266
LEU A 197
 None
 1.21A 1r30B-5tzbA:
undetectable		 1r30B-5tzbA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		3 / 3 GLY A  39
GLU A  37
ASP A  40
 None
 0.69A 2b25B-5tzbA:
undetectable		 2b25B-5tzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 GLY A 176
GLY A 162
GLY A 161
ALA A 332
ASN A  35
 None
 1.09A 2dpmA-5tzbA:
undetectable		 2dpmA-5tzbA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 11 ILE A  21
GLY A  16
THR A  22
ARG A   2
GLY A 195
 None
 1.14A 2fn1B-5tzbA:
undetectable		 2fn1B-5tzbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		4 / 8 THR A  88
VAL A 107
ASN A 109
ALA A 113
 None
 1.18A 2ij7C-5tzbA:
undetectable		 2ij7C-5tzbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		4 / 4 THR A   3
ARG A   2
GLU A 327
ASN A  19
 None
 1.23A 2w13A-5tzbA:
undetectable		 2w13A-5tzbA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 10 THR A  33
LEU A 133
VAL A 346
GLY A 176
THR A 167
 None
 1.25A 2wd9C-5tzbA:
undetectable		 2wd9C-5tzbA:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 11 GLY A  73
THR A  96
GLU A 127
ASN A 201
SER A 239
 None
 0.41A 3ndvA-5tzbA:
51.6
3ndvB-5tzbA:
51.5		 3ndvA-5tzbA:
40.14
3ndvB-5tzbA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 11 GLY A  73
THR A  96
GLU A 127
ASN A 201
SER A 239
 None
 0.40A 3ndvA-5tzbA:
51.5
3ndvB-5tzbA:
51.6		 3ndvA-5tzbA:
40.14
3ndvB-5tzbA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 11 GLY A  73
THR A  96
GLU A 127
ASN A 201
SER A 239
 None
 0.39A 3ndvC-5tzbA:
51.5
3ndvD-5tzbA:
51.4		 3ndvC-5tzbA:
40.14
3ndvD-5tzbA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 11 GLY A  73
THR A  96
GLU A 127
ASN A 201
SER A 239
 None
 0.41A 3ndvC-5tzbA:
51.5
3ndvD-5tzbA:
51.4		 3ndvC-5tzbA:
40.14
3ndvD-5tzbA:
40.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 LEU A 208
GLY A 176
GLY A 168
HIS A 172
GLY A 350
 None
 1.14A 4blvA-5tzbA:
undetectable		 4blvA-5tzbA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 GLY A 271
GLY A 272
VAL A 330
ILE A 240
PHE A 281
 None
 1.14A 4fglA-5tzbA:
undetectable
4fglB-5tzbA:
undetectable		 4fglA-5tzbA:
20.51
4fglB-5tzbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 LEU A 133
LEU A 132
GLY A 131
HIS A 140
THR A  45
 None
 1.13A 4olmA-5tzbA:
undetectable		 4olmA-5tzbA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		4 / 6 CYH A 171
GLU A 274
GLY A 271
GLY A 270
 None
 0.92A 5a06D-5tzbA:
undetectable		 5a06D-5tzbA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.14A 5igyA-5tzbA:
undetectable		 5igyA-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 ILE A 329
GLY A 179
ASN A 331
ILE A 244
PHE A 281
 None
 1.03A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 ILE A 329
GLY A 265
GLU A 173
ARG A 209
ALA A 211
 None
 1.15A 5ih0A-5tzbA:
undetectable		 5ih0A-5tzbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 GLU A 127
ASP A 279
ASN A 201
ALA A 332
VAL A 325
 None
 1.36A 5kbwB-5tzbA:
undetectable		 5kbwB-5tzbA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		4 / 7 GLY A 162
GLY A 164
HIS A  31
LYS A 175
 None
 0.95A 5n9xA-5tzbA:
undetectable		 5n9xA-5tzbA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		5 / 12 GLY A 348
VAL A 339
GLY A 161
GLY A 176
ALA A 335
 None
 1.16A 5x7fA-5tzbA:
undetectable		 5x7fA-5tzbA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tzb D-AMINOPEPTIDASE
(Burkholderia
sp.
LK4) 		3 / 3 ASN A 201
VAL A 269
HIS A 172
 None
 0.80A 6a5yD-5tzbA:
undetectable		 6a5yD-5tzbA:
12.11