SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 LEU C 278
ILE C 309
SER C 318
GLN C 271
PHE C 262
 None
 1.21A 1xotB-5tzkC:
undetectable		 1xotB-5tzkC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 4 LEU C 162
PRO C  71
ILE C   6
LEU C  79
 None
UDP  C 401 (-3.5A)
None
None
 1.13A 1ya4B-5tzkC:
undetectable		 1ya4B-5tzkC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 LEU C  20
ASN C  21
LEU C  23
ALA C  24
LEU C  59
 None
 0.75A 2aa6A-5tzkC:
undetectable		 2aa6A-5tzkC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLU C 248
MET C 183
PHE C 249
ILE C 232
 None
 1.27A 2w98B-5tzkC:
undetectable		 2w98B-5tzkC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 12 VAL C   5
LEU C  19
SER C  22
VAL C   7
ILE C  16
 None
 1.30A 3frqA-5tzkC:
undetectable		 3frqA-5tzkC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 4 TYR C 222
TYR C 312
GLU C 316
GLY C 261
 None
 1.28A 3reqA-5tzkC:
3.2		 3reqA-5tzkC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 11 ASN C 335
ILE C 329
ASP C 349
GLY C 347
VAL C 315
 None
 1.08A 3rukD-5tzkC:
undetectable		 3rukD-5tzkC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 SER C  92
ASP C  94
THR C  17
ILE C  16
 UDP  C 401 (-2.8A)
MN  C 402 ( 4.0A)
None
None
 0.98A 4acbC-5tzkC:
3.1		 4acbC-5tzkC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 5 VAL C 289
ARG C 288
GLU C 239
LEU C 233
 None
 1.38A 4hojA-5tzkC:
undetectable		 4hojA-5tzkC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 10 VAL C   5
ALA C  78
SER C  92
LEU C  20
VAL C  35
 None
None
UDP  C 401 (-2.8A)
None
None
 1.42A 4kyaC-5tzkC:
undetectable		 4kyaC-5tzkC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 11 VAL C   5
ALA C  78
SER C  92
LEU C  20
VAL C  35
 None
None
UDP  C 401 (-2.8A)
None
None
 1.43A 4kyaE-5tzkC:
undetectable		 4kyaE-5tzkC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		5 / 11 VAL C   5
ALA C  78
SER C  92
LEU C  20
VAL C  35
 None
None
UDP  C 401 (-2.8A)
None
None
 1.41A 4kyaG-5tzkC:
2.7		 4kyaG-5tzkC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		3 / 3 MET C 225
ASP C 178
PHE C 181
 None
SO4  C 406 ( 4.6A)
None
 0.99A 4xeyA-5tzkC:
undetectable		 4xeyA-5tzkC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		3 / 3 MET C 225
ASP C 178
PHE C 181
 None
SO4  C 406 ( 4.6A)
None
 0.96A 4xeyB-5tzkC:
undetectable		 4xeyB-5tzkC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5tzk GLYCOSYL TRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLN C 283
GLU C 287
HIS C 302
ALA C 306
 None
 1.31A 6f6jC-5tzkC:
undetectable
6f6jD-5tzkC:
undetectable		 6f6jC-5tzkC:
23.19
6f6jD-5tzkC:
23.19