SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 GLY A  94
GLY A2265
SER A2268
GLY A2238
 None
 0.73A 1d0vA-5tzyA:
undetectable		 1d0vA-5tzyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 LEU A  54
PHE A  96
GLY A  94
TRP A 131
 None
 1.07A 1fapB-5tzyA:
3.9		 1fapB-5tzyA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 ALA A2266
SER A  69
ARG A 183
LEU A  90
 None
None
MK6  A2402 (-4.0A)
None
 1.10A 1gahA-5tzyA:
undetectable		 1gahA-5tzyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 GLY A  94
GLY A2265
SER A2268
GLY A2238
 None
 0.73A 1jhaA-5tzyA:
undetectable		 1jhaA-5tzyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 VAL A2237
GLY A  94
LEU A2233
TYR A2240
ASN A2241
 None
 1.19A 1sq5D-5tzyA:
undetectable		 1sq5D-5tzyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 VAL A 134
LEU A 190
GLY A  93
LEU A  59
TYR A  12
 7OS  A2403 (-4.6A)
7OS  A2403 (-4.3A)
None
None
None
 1.14A 2cbrA-5tzyA:
undetectable		 2cbrA-5tzyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 159
GLY A 148
ALA A 146
ASN A 155
PRO A 168
 None
 1.06A 2dpmA-5tzyA:
undetectable		 2dpmA-5tzyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ALA A  92
GLY A  94
LEU A  97
PRO A  89
PHE A  88
 None
 1.08A 2f8lA-5tzyA:
undetectable		 2f8lA-5tzyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 LYS A  62
ARG A 183
LEU A2262
 None
MK6  A2402 (-4.0A)
None
 1.19A 3v4tE-5tzyA:
undetectable		 3v4tE-5tzyA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A2262
PHE A  82
GLU A 172
GLU A  65
ALA A  63
 None
 1.17A 4aqlA-5tzyA:
undetectable		 4aqlA-5tzyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 PHE A  96
ALA A  92
VAL A 134
ALA A  99
VAL A 126
 None
None
7OS  A2403 (-4.6A)
7OS  A2403 (-3.3A)
None
 1.21A 4df3A-5tzyA:
undetectable		 4df3A-5tzyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 ALA A1074
VAL A1071
ASP A1070
LEU A1007
 None
 1.14A 4e7gA-5tzyA:
undetectable		 4e7gA-5tzyA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 VAL A 134
ALA A  85
PHE A  88
LEU A  90
LEU A 171
 7OS  A2403 (-4.6A)
None
None
None
MK6  A2402 (-4.7A)
 1.09A 4i1rA-5tzyA:
undetectable		 4i1rA-5tzyA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 GLU A1064
LYS A1062
ASN A1068
 None
 0.69A 4y1dA-5tzyA:
undetectable
4y1dD-5tzyA:
undetectable		 4y1dA-5tzyA:
16.46
4y1dD-5tzyA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 LEU A  90
VAL A2269
LEU A  55
ILE A2263
ALA A  15
 None
 1.20A 5og9A-5tzyA:
undetectable		 5og9A-5tzyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 LEU A  55
LEU A  59
SER A2268
ALA A  15
 None
 1.05A 5uunA-5tzyA:
undetectable		 5uunA-5tzyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 HIS A  86
VAL A2269
LEU A  55
ALA A2266
 None
 1.43A 6d8pB-5tzyA:
undetectable		 6d8pB-5tzyA:
22.40