SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 428
PRO A 426
THR A 427
 None
 0.89A 1a7yB-5u03A:
undetectable		 1a7yB-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 427
THR A 428
PRO A 426
 None
 0.86A 1i3wF-5u03A:
undetectable		 1i3wF-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 428
PRO A 426
THR A 427
 None
 0.86A 1mnvD-5u03A:
undetectable		 1mnvD-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 427
THR A 428
PRO A 426
 None
 0.79A 1mnvD-5u03A:
undetectable		 1mnvD-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 427
THR A 428
PRO A 426
 None
 0.85A 1qfiA-5u03A:
undetectable		 1qfiA-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 LEU A 404
GLU A 423
GLY A 374
SER A 421
ARG A 376
 None
 1.09A 2br4A-5u03A:
undetectable		 2br4A-5u03A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 11 LEU A 267
LEU A 213
VAL A 262
VAL A  23
ILE A  26
 None
 1.11A 2uxoB-5u03A:
undetectable		 2uxoB-5u03A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 ARG A 269
GLN A 240
ARG A 205
GLN A 167
 None
 1.49A 2vxaA-5u03A:
undetectable
2vxaB-5u03A:
undetectable
2vxaK-5u03A:
undetectable		 2vxaA-5u03A:
8.12
2vxaB-5u03A:
8.12
2vxaK-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 ARG A 269
GLN A 240
ARG A 205
GLN A 167
 None
 1.45A 2vxaD-5u03A:
undetectable
2vxaE-5u03A:
undetectable
2vxaL-5u03A:
undetectable		 2vxaD-5u03A:
8.12
2vxaE-5u03A:
8.12
2vxaL-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 ARG A 269
GLN A 240
ARG A 205
GLN A 167
 None
 1.47A 2vxaH-5u03A:
undetectable
2vxaI-5u03A:
undetectable
2vxaJ-5u03A:
undetectable		 2vxaH-5u03A:
8.12
2vxaI-5u03A:
8.12
2vxaJ-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 GLN A 167
ARG A 205
ARG A 269
GLN A 240
 None
 1.45A 2vxaD-5u03A:
undetectable
2vxaJ-5u03A:
undetectable
2vxaL-5u03A:
undetectable		 2vxaD-5u03A:
8.12
2vxaJ-5u03A:
8.12
2vxaL-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 GLN A 167
ARG A 269
GLN A 240
ARG A 205
 None
 1.48A 2vxaH-5u03A:
undetectable
2vxaJ-5u03A:
undetectable
2vxaK-5u03A:
undetectable		 2vxaH-5u03A:
8.12
2vxaJ-5u03A:
8.12
2vxaK-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 GLN A 167
ARG A 269
GLN A 240
ARG A 205
 None
 1.43A 2vxaA-5u03A:
undetectable
2vxaK-5u03A:
undetectable
2vxaL-5u03A:
undetectable		 2vxaA-5u03A:
8.12
2vxaK-5u03A:
8.12
2vxaL-5u03A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 4 SER A  51
GLY A 371
GLY A 305
LYS A 306
 None
 1.24A 2y4nB-5u03A:
3.1		 2y4nB-5u03A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 GLU A 322
SER A 248
VAL A 247
 None
None
ATP  A 601 (-3.9A)
 0.82A 3eeoA-5u03A:
2.9		 3eeoA-5u03A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 9 LEU A 213
VAL A   6
GLY A  24
ILE A  26
ILE A 178
 None
 1.10A 3ekqB-5u03A:
undetectable		 3ekqB-5u03A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 10 ILE A 385
VAL A 369
GLY A 397
VAL A 433
LEU A 497
 None
 1.24A 3elzC-5u03A:
undetectable		 3elzC-5u03A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 10 ILE A 385
VAL A 369
GLY A 397
VAL A 433
LEU A 497
 None
 1.12A 3em0A-5u03A:
undetectable		 3em0A-5u03A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 VAL A 262
VAL A 253
ILE A   4
VAL A   6
 None
 0.79A 3hjoB-5u03A:
undetectable		 3hjoB-5u03A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 9 VAL A 262
ILE A 242
ALA A  20
VAL A 253
VAL A 244
 None
 1.20A 3me6D-5u03A:
undetectable		 3me6D-5u03A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 9 GLY A 208
GLN A 167
LEU A 207
ARG A 164
ILE A 160
 None
 1.32A 3nbqD-5u03A:
3.3		 3nbqD-5u03A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 TYR A 525
TYR A 468
GLU A 528
 None
 0.79A 3pfgA-5u03A:
undetectable		 3pfgA-5u03A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 10 GLU A 513
VAL A 463
LEU A 555
TYR A 554
PHE A 519
 None
 1.29A 3qeoA-5u03A:
5.2		 3qeoA-5u03A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 4 LYS A 284
GLN A 277
ILE A 274
LEU A  27
 None
 1.41A 3qt0A-5u03A:
undetectable		 3qt0A-5u03A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
 ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
 0.93A 4ax8A-5u03A:
undetectable		 4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 GLY A  15
ILE A  18
SER A 181
VAL A 180
ILE A 178
 ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
 1.00A 4ax8A-5u03A:
undetectable		 4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 SER A  22
VAL A  23
GLN A 240
ILE A 178
PHE A 266
 None
 1.44A 4c49C-5u03A:
undetectable		 4c49C-5u03A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 SER A  22
VAL A  23
GLN A 240
ILE A 178
PHE A 266
 None
 1.44A 4c49D-5u03A:
undetectable		 4c49D-5u03A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 LYS A 193
LYS A 195
PRO A 196
 None
 0.91A 4dv1L-5u03A:
undetectable		 4dv1L-5u03A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A 428
PRO A 426
THR A 427
 None
 0.84A 4hivD-5u03A:
undetectable		 4hivD-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 10 VAL A 144
VAL A   6
ILE A 178
LEU A 272
LEU A 270
 None
 1.21A 4jtqA-5u03A:
undetectable		 4jtqA-5u03A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 GLU A 510
ARG A 449
HIS A 480
 None
 0.70A 4kf9A-5u03A:
undetectable		 4kf9A-5u03A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 ASP A 134
ARG A 477
ARG A 532
 None
 0.95A 4x5iA-5u03A:
undetectable		 4x5iA-5u03A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 THR A   7
GLY A 149
GLY A 148
LEU A 147
LEU A 207
 None
UTP  A 602 (-4.1A)
UTP  A 602 (-3.5A)
None
None
 0.98A 5c0oF-5u03A:
undetectable		 5c0oF-5u03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 8 VAL A   6
LEU A  78
TYR A  74
GLY A  24
 None
 0.71A 5f1aA-5u03A:
undetectable		 5f1aA-5u03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 7 VAL A   6
LEU A  78
TYR A  74
GLY A  24
 None
 0.71A 5f1aB-5u03A:
undetectable		 5f1aB-5u03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		4 / 5 GLY A  64
ARG A 479
ASP A  63
GLN A 128
 None
 1.37A 5ubbA-5u03A:
undetectable		 5ubbA-5u03A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		3 / 3 ARG A  81
PHE A  59
ARG A 532
 None
 1.22A 5y9yA-5u03A:
undetectable		 5y9yA-5u03A:
20.00