SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 ALA A 627
VAL A 630
TRP A 648
 None
 0.91A 1jnoA-5u04A:
undetectable		 1jnoA-5u04A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 ALA A 627
VAL A 630
TRP A 648
 None
 0.91A 1jnoB-5u04A:
undetectable		 1jnoB-5u04A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 400
VAL A 427
TRP A 433
 None
 0.86A 2cc8A-5u04A:
undetectable		 2cc8A-5u04A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 484
VAL A 436
TRP A 433
 None
 0.76A 2cc8A-5u04A:
undetectable		 2cc8A-5u04A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 400
VAL A 427
TRP A 433
 None
 0.87A 2ccbA-5u04A:
undetectable		 2ccbA-5u04A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 484
VAL A 436
TRP A 433
 None
 0.74A 2ccbA-5u04A:
undetectable		 2ccbA-5u04A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		4 / 5 LEU A 617
LEU A 382
LEU A 553
MET A 499
 None
 0.95A 2oaxF-5u04A:
undetectable		 2oaxF-5u04A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 400
VAL A 427
TRP A 433
 None
 0.86A 2vx9A-5u04A:
undetectable		 2vx9A-5u04A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 PHE A 484
VAL A 436
TRP A 433
 None
 0.75A 2vx9A-5u04A:
undetectable		 2vx9A-5u04A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 GLY A 850
TRP A 333
VAL A 336
 None
 0.63A 3n62B-5u04A:
undetectable		 3n62B-5u04A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 GLY A 850
TRP A 333
VAL A 336
 None
 0.60A 3n65B-5u04A:
undetectable		 3n65B-5u04A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 GLY A 850
TRP A 333
VAL A 336
 None
 0.63A 3n66B-5u04A:
undetectable		 3n66B-5u04A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		4 / 7 ASP A 788
ILE A 876
VAL A 872
ARG A 873
 None
 1.10A 3p6hA-5u04A:
undetectable		 3p6hA-5u04A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 ARG A 647
ASP A 635
GLN A 634
 None
 0.73A 4azsA-5u04A:
undetectable		 4azsA-5u04A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		3 / 3 GLY A 850
TRP A 333
VAL A 336
 None
 0.58A 5vuoB-5u04A:
undetectable		 5vuoB-5u04A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		4 / 7 HIS A 714
ASP A 846
GLY A 842
ASN A 716
 ZN  A1001 (-3.2A)
None
None
ZN  A1001 ( 4.6A)
 1.14A 5x7pA-5u04A:
undetectable		 5x7pA-5u04A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5u04 ZIKA VIRUS NS5 RDRP
(Zika
virus) 		4 / 5 HIS A 714
ASP A 846
GLY A 842
ASN A 716
 ZN  A1001 (-3.2A)
None
None
ZN  A1001 ( 4.6A)
 1.18A 5x7pB-5u04A:
undetectable		 5x7pB-5u04A:
18.49