SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 VAL A 137
ILE A 395
ALA A 398
SER A 401
LEU A 404
None
SO4  A1209 (-4.5A)
SO4  A1209 ( 3.9A)
None
None
1.18A 1eqgA-5u09A:
undetectable
1eqgA-5u09A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 11 VAL A 137
ILE A 395
ALA A 398
SER A 401
LEU A 404
None
SO4  A1209 (-4.5A)
SO4  A1209 ( 3.9A)
None
None
1.16A 1eqgB-5u09A:
undetectable
1eqgB-5u09A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 ILE A 353
ILE A 354
TYR A 294
ILE A 297
ALA A 342
None
1.13A 1jtxA-5u09A:
1.7
1jtxA-5u09A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
None
1.09A 1q23H-5u09A:
undetectable
1q23I-5u09A:
undetectable
1q23H-5u09A:
17.13
1q23I-5u09A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.21A 1xmuA-5u09A:
undetectable
1xmuA-5u09A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.24A 1xoqA-5u09A:
undetectable
1xoqA-5u09A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.24A 1xoqB-5u09A:
undetectable
1xoqB-5u09A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 5 VAL A 282
THR A 283
VAL A 204
GLY A 205
None
1.13A 2p2fA-5u09A:
2.9
2p2fA-5u09A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 4 VAL A 282
THR A 283
VAL A 204
GLY A 205
None
1.10A 2p2fB-5u09A:
3.1
2p2fB-5u09A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
3 / 3 PHE A 102
SER A 383
LEU A 387
None
7DY  A1210 (-3.0A)
7DY  A1210 (-4.6A)
0.79A 2w1bA-5u09A:
undetectable
2w1bA-5u09A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 5 TYR A 397
ILE A 156
LEU A 341
LEU A 345
None
1.15A 2zb7A-5u09A:
3.3
2zb7A-5u09A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 ASN A 187
ARG A 186
HIS A 270
ILE A 267
ASP A 104
SO4  A1211 (-4.5A)
None
None
None
None
1.43A 3a25A-5u09A:
4.0
3a25A-5u09A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 11 LEU A 159
GLY A 157
ILE A 141
PRO A 151
SER A 152
None
1.25A 3bjwB-5u09A:
undetectable
3bjwB-5u09A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 11 LEU A 159
GLY A 157
ILE A 141
PRO A 151
SER A 152
None
1.26A 3bjwH-5u09A:
0.6
3bjwH-5u09A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A1012
GLY A1014
SER A1022
LEU A1023
SER A1111
None
1.26A 3gyqA-5u09A:
3.7
3gyqB-5u09A:
3.5
3gyqA-5u09A:
21.76
3gyqB-5u09A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 10 ILE A 353
PHE A 155
SER A 152
ALA A 342
ALA A 210
None
1.25A 3lw5B-5u09A:
undetectable
3lw5B-5u09A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 7 ILE A1070
ILE A1072
VAL A1105
LEU A1108
None
0.69A 3r9vA-5u09A:
1.0
3r9vB-5u09A:
3.2
3r9vA-5u09A:
21.76
3r9vB-5u09A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 4 PHE A 208
TYR A 215
ILE A 353
LEU A 352
None
1.15A 3sudA-5u09A:
undetectable
3sudA-5u09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 5 PHE A 208
TYR A 215
ILE A 353
LEU A 352
None
1.19A 3sueC-5u09A:
undetectable
3sueC-5u09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
None
1.43A 4a79A-5u09A:
undetectable
4a79A-5u09A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
None
1.37A 4a79B-5u09A:
undetectable
4a79B-5u09A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 11 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
None
1.42A 4a7aA-5u09A:
undetectable
4a7aA-5u09A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 TRP A 279
THR A 283
LEU A 359
LEU A 360
GLY A 357
None
None
7DY  A1210 ( 4.9A)
None
None
1.40A 4c9kA-5u09A:
undetectable
4c9kA-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 TRP A 279
THR A 283
LEU A 359
LEU A 360
GLY A 357
None
None
7DY  A1210 ( 4.9A)
None
None
1.37A 4c9kB-5u09A:
undetectable
4c9kB-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 TRP A 279
THR A 283
LEU A 359
LEU A 360
GLY A 357
None
None
7DY  A1210 ( 4.9A)
None
None
1.40A 4c9pA-5u09A:
undetectable
4c9pA-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 TRP A 279
THR A 283
LEU A 359
LEU A 360
VAL A 204
None
None
7DY  A1210 ( 4.9A)
None
None
1.40A 4c9pA-5u09A:
undetectable
4c9pA-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 6 GLU A 273
LEU A 276
MET A 363
ASP A 366
None
1.50A 4cevA-5u09A:
2.5
4cevB-5u09A:
2.5
4cevA-5u09A:
20.40
4cevB-5u09A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 6 MET A 363
ASP A 366
GLU A 273
LEU A 276
None
1.49A 4cevA-5u09A:
2.4
4cevC-5u09A:
2.5
4cevA-5u09A:
20.40
4cevC-5u09A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 6 GLU A 273
LEU A 276
MET A 363
ASP A 366
None
1.50A 4cevD-5u09A:
2.5
4cevE-5u09A:
2.5
4cevD-5u09A:
20.40
4cevE-5u09A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 6 GLU A 273
LEU A 276
MET A 363
ASP A 366
None
1.47A 4cevE-5u09A:
undetectable
4cevF-5u09A:
undetectable
4cevE-5u09A:
20.40
4cevF-5u09A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 9 CYH A 386
PHE A 268
ILE A 362
MET A 363
7DY  A1210 (-3.8A)
7DY  A1210 ( 4.7A)
None
None
1.37A 4jvlA-5u09A:
undetectable
4jvlA-5u09A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 10 TRP A 356
LEU A 165
TRP A 279
ALA A 244
GLY A 194
None
PEG  A1206 ( 4.9A)
None
None
None
1.29A 4rn6A-5u09A:
undetectable
4rn6A-5u09A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 9 PRO A 394
LEU A 138
GLY A 157
SER A 390
VAL A 161
SO4  A1209 (-4.7A)
None
None
7DY  A1210 ( 4.1A)
None
1.45A 4x3mA-5u09A:
4.2
4x3mA-5u09A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 4 GLY A1039
VAL A1048
PHE A1035
ILE A1116
None
1.15A 4xv2B-5u09A:
undetectable
4xv2B-5u09A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
4 / 5 ALA A 293
TYR A 292
PRO A1123
GLY A1161
None
None
None
PEG  A1214 (-4.5A)
0.99A 5eslA-5u09A:
undetectable
5eslA-5u09A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 12 ASP A 163
LEU A 404
ILE A 141
PHE A 155
LEU A 207
None
1.22A 5nn8A-5u09A:
undetectable
5nn8A-5u09A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo
sapiens;
Pyrococcus
abyssi)
5 / 10 LEU A1146
ILE A1117
GLY A1155
LEU A1129
ALA A1128
None
1.08A 5o96C-5u09A:
2.1
5o96D-5u09A:
2.7
5o96C-5u09A:
20.08
5o96D-5u09A:
20.08