SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 502
PHE A 505
ALA A 506
LEU A 538
 None
 0.90A 1ukbA-5u0kA:
undetectable		 1ukbA-5u0kA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 538
ARG A 520
LEU A 491
ALA A 527
 None
 1.12A 3b9mA-5u0kA:
undetectable		 3b9mA-5u0kA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 502
ARG A 504
ARG A 503
 None
 0.96A 4yiaB-5u0kA:
undetectable		 4yiaB-5u0kA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 538
LEU A 502
THR A 521
ALA A 522
GLN A 514
 None
 1.10A 5o96A-5u0kA:
undetectable
5o96B-5u0kA:
undetectable		 5o96A-5u0kA:
19.76
5o96B-5u0kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HAU_B_ACTB502_0
(MRNA EXPORT FACTOR
ICP27 HOMOLOG)		 5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 491
TYR A 517
ARG A 520
ASP A 516
 None
 1.50A 6hauA-5u0kA:
0.0
6hauB-5u0kA:
undetectable		 6hauA-5u0kA:
20.16
6hauB-5u0kA:
20.16