SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 THR A 386
LEU A 363
SER A 364
VAL A 368
 EDO  A 505 ( 3.9A)
None
None
None
 0.65A 1ictD-5u0lA:
undetectable		 1ictD-5u0lA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 LEU A 271
GLU A 305
VAL A 306
LEU A 255
LEU A 288
 None
 1.25A 1mrqA-5u0lA:
undetectable		 1mrqA-5u0lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 453
CYH A 282
THR A 283
ILE A 430
PHE A 446
 None
EDO  A 509 (-3.3A)
EDO  A 509 (-3.1A)
None
8YP  A 507 ( 3.5A)
 1.45A 1p93D-5u0lA:
undetectable		 1p93D-5u0lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 LEU A 351
PHE A 275
ILE A 310
ALA A 308
 None
 1.08A 2j5mA-5u0lA:
undetectable		 2j5mA-5u0lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 GLY A 158
ASN A 157
ALA A 163
VAL A 170
 8YP  A 507 (-2.9A)
None
None
None
 0.74A 3a2qA-5u0lA:
undetectable		 3a2qA-5u0lA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 LEU A 255
LEU A 437
ALA A 396
ALA A 409
VAL A 431
 None
 1.29A 3b0wA-5u0lA:
undetectable		 3b0wA-5u0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A   4
PRO A 174
GLY A 153
PRO A 152
 None
 0.92A 3hcrA-5u0lA:
2.3		 3hcrA-5u0lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 LEU A 233
GLY A 209
LEU A  41
SER A  40
ALA A 144
 None
EDO  A 508 ( 3.7A)
None
None
None
 1.18A 3i5uB-5u0lA:
4.1		 3i5uB-5u0lA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 366
ALA A 370
ALA A 347
LEU A 343
SER A 364
 None
 1.22A 3mteA-5u0lA:
4.2		 3mteA-5u0lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 9 ILE A  70
PHE A  73
ALA A 163
LEU A 164
ALA A 192
 None
 0.91A 3ozvB-5u0lA:
4.5		 3ozvB-5u0lA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 ARG A 281
GLU A 102
THR A 101
 EDO  A 509 ( 4.9A)
None
None
 0.79A 3v4tA-5u0lA:
undetectable		 3v4tA-5u0lA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 GLY A 410
ASN A 432
LEU A 437
ASN A 253
 None
 1.01A 3zqtA-5u0lA:
undetectable		 3zqtA-5u0lA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 LEU A 212
ILE A  10
ASN A  37
VAL A   8
LEU A 201
 None
 0.97A 4fr0A-5u0lA:
undetectable		 4fr0A-5u0lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 MET A 106
LEU A  77
PRO A 162
SER A 113
 None
 1.31A 4kmmB-5u0lA:
2.3		 4kmmB-5u0lA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 PHE A 146
ALA A 213
LEU A 245
PHE A 237
 EDO  A 508 ( 4.0A)
EDO  A 508 ( 4.8A)
None
None
 1.10A 4uymB-5u0lA:
undetectable		 4uymB-5u0lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 LEU A 335
LEU A 363
SER A 364
VAL A 368
 None
 1.04A 5a6iA-5u0lA:
undetectable		 5a6iA-5u0lA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 SER A 458
ALA A 459
HIS A 159
LEU A 155
 8YP  A 507 (-2.3A)
8YP  A 507 (-2.8A)
8YP  A 507 (-3.1A)
8YP  A 507 (-3.8A)
 1.20A 5dzkc-5u0lA:
undetectable
5dzkq-5u0lA:
undetectable		 5dzkc-5u0lA:
17.81
5dzkq-5u0lA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 SER A 458
ALA A 459
HIS A 159
LEU A 155
 8YP  A 507 (-2.3A)
8YP  A 507 (-2.8A)
8YP  A 507 (-3.1A)
8YP  A 507 (-3.8A)
 1.23A 5dzkg-5u0lA:
undetectable
5dzku-5u0lA:
undetectable		 5dzkg-5u0lA:
17.81
5dzku-5u0lA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 THR A  92
THR A 101
LEU A 276
 None
 0.57A 5m66D-5u0lA:
4.5		 5m66D-5u0lA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 SER A  24
LEU A  84
LEU A   4
ILE A  88
PRO A 152
 None
 1.46A 6dm2B-5u0lA:
2.8
6dm2C-5u0lA:
undetectable		 6dm2B-5u0lA:
9.57
6dm2C-5u0lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 ILE A  88
PRO A 152
SER A  24
LEU A  84
LEU A   4
 None
 1.46A 6dm2A-5u0lA:
undetectable
6dm2D-5u0lA:
undetectable		 6dm2A-5u0lA:
9.57
6dm2D-5u0lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 GLY A 382
LEU A 335
TYR A 149
GLN A 280
 None
 1.09A 6ji6A-5u0lA:
undetectable		 6ji6A-5u0lA:
20.21