SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE N 424
LEU N 471
ALA N 453
GLU N 454
 None
 1.28A 1xvaA-5u0pN:
undetectable
1xvaB-5u0pN:
undetectable		 1xvaA-5u0pN:
16.00
1xvaB-5u0pN:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA N 453
LEU N 450
LEU N 435
ILE N 406
PRO N 447
 None
 1.15A 2qxsA-5u0pN:
undetectable		 2qxsA-5u0pN:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA N 453
LEU N 450
LEU N 435
ILE N 406
PRO N 447
 None
 1.16A 2qxsB-5u0pN:
undetectable		 2qxsB-5u0pN:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN N 273
PHE N 224
TYR N 236
 None
 0.83A 3ucjB-5u0pN:
undetectable		 3ucjB-5u0pN:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN N 273
PHE N 224
TYR N 236
 None
 0.79A 3ucjA-5u0pN:
undetectable		 3ucjA-5u0pN:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5u0p MEDIATOR COMPLEX
SUBUNIT 14
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS N 159
ASN N 162
LEU N 161
 None
 0.84A 6f7lB-5u0pN:
undetectable		 6f7lB-5u0pN:
17.91