SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ALA H 184
VAL R  10
TRP R 165
 None
 0.93A 1av2A-5u0sH:
undetectable
1av2B-5u0sH:
undetectable		 1av2A-5u0sH:
6.20
1av2B-5u0sH:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
MEDIATOR COMPLEX
SUBUNIT 8
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ILE H  16
THR H  74
ILE H  76
LEU F 124
ARG F 128
 None
 1.02A 1dhfB-5u0sH:
undetectable		 1dhfB-5u0sH:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ALA H 184
VAL R  10
TRP R 165
 None
 0.96A 1w5uA-5u0sH:
undetectable
1w5uB-5u0sH:
undetectable		 1w5uA-5u0sH:
6.20
1w5uB-5u0sH:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5u0s RNA POLYMERASE II
SUBUNIT RPB6
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL f 138
TRP f 136
VAL f 124
 None
 0.95A 2izqC-5u0sf:
undetectable
2izqD-5u0sf:
undetectable		 2izqC-5u0sf:
8.03
2izqD-5u0sf:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 TRP R 165
ALA H 184
VAL R  10
 None
 0.93A 2izqC-5u0sR:
undetectable
2izqD-5u0sR:
undetectable		 2izqC-5u0sR:
12.33
2izqD-5u0sR:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		4 / 4 THR F 106
VAL F  79
GLY F  75
THR F  74
 None
 0.87A 3cflA-5u0sF:
undetectable		 3cflA-5u0sF:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
MEDIATOR COMPLEX
SUBUNIT 8
(Schizosaccharomy
ces
pombe) 		5 / 10 GLU H  88
LEU F  88
ILE F  91
ILE F 115
THR H  92
 None
 1.11A 3jw3A-5u0sH:
undetectable		 3jw3A-5u0sH:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU F  34
PHE F  37
ILE F  91
PHE F  87
 None
 0.98A 3ko0B-5u0sF:
undetectable		 3ko0B-5u0sF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 TRP R 165
ALA H 184
VAL R  10
 None
 1.01A 3l8lA-5u0sR:
undetectable
3l8lB-5u0sR:
undetectable		 3l8lA-5u0sR:
12.33
3l8lB-5u0sR:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 TRP R 165
ALA H 184
VAL R  10
 None
 0.93A 3l8lC-5u0sR:
undetectable
3l8lD-5u0sR:
undetectable		 3l8lC-5u0sR:
12.33
3l8lD-5u0sR:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		4 / 4 LYS F 103
PRO F 104
LEU F 105
ASN F  95
 None
 1.38A 3tpxC-5u0sF:
0.0		 3tpxC-5u0sF:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5u0s MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL R 169
PHE R 199
LEU R  26
PHE R 133
VAL R 138
 None
 1.04A 3w68B-5u0sR:
undetectable		 3w68B-5u0sR:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5u0s MEDIATOR COMPLEX
SUBUNIT 6
MEDIATOR COMPLEX
SUBUNIT 8
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 ILE H  16
THR H  74
ILE H  76
LEU F 124
ARG F 128
 None
 1.13A 4x5fB-5u0sH:
undetectable		 4x5fB-5u0sH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 8 LEU H 188
LEU R 167
TYR R   5
MET H 195
 None
 1.09A 5hbsA-5u0sH:
undetectable		 5hbsA-5u0sH:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u0s RNA POLYMERASE II
SUBUNIT RPB6
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL f 124
LEU f 108
MET f 112
 None
 0.87A 5ikrA-5u0sf:
undetectable		 5ikrA-5u0sf:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5u0s MEDIATOR COMPLEX
SUBUNIT 18
MEDIATOR COMPLEX
SUBUNIT 8
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL R  18
GLU H 180
GLU H 181
 None
 0.79A 5jsdB-5u0sR:
undetectable
5jsdC-5u0sR:
undetectable		 5jsdB-5u0sR:
14.74
5jsdC-5u0sR:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 7 ARG R  97
TYR R 141
HIS R 168
LEU H 188
 None
 1.24A 6g2pA-5u0sR:
undetectable		 6g2pA-5u0sR:
18.07