SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
 None
 0.75A 1lqtB-5u0uG:
undetectable		 1lqtB-5u0uG:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
 None
 0.79A 1lquB-5u0uG:
undetectable		 1lquB-5u0uG:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.35A 2eimJ-5u0uG:
undetectable		 2eimJ-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.34A 2eimW-5u0uG:
undetectable		 2eimW-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 PRO G  45
TYR G  95
TYR G 177
PRO G 185
 None
 1.30A 2ombA-5u0uG:
21.5
2ombB-5u0uG:
21.0		 2ombA-5u0uG:
26.36
2ombB-5u0uG:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 7 PRO G  45
TYR G 177
PRO G 185
TYR G 228
 None
 1.11A 2ombC-5u0uG:
21.2
2ombD-5u0uG:
21.2		 2ombC-5u0uG:
26.36
2ombD-5u0uG:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.32A 3ag2J-5u0uG:
undetectable		 3ag2J-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.32A 3ag4J-5u0uG:
undetectable		 3ag4J-5u0uG:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		5 / 12 HIS G  35
VAL G  37
TRP G  50
TRP G 117
TYR G 111
 None
 1.14A 3wfhA-5u0uG:
20.3
3wfhB-5u0uG:
14.7		 3wfhA-5u0uG:
39.08
3wfhB-5u0uG:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		5 / 12 HIS G  35
VAL G  37
TRP G  50
TRP G 117
TYR G 111
 None
 1.10A 3whxA-5u0uG:
20.3
3whxB-5u0uG:
14.7		 3whxA-5u0uG:
38.49
3whxB-5u0uG:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 6 PRO G 112
GLY G 241
ALA G 233
GLN G  39
 None
 1.09A 4g0uA-5u0uG:
undetectable		 4g0uA-5u0uG:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 7 PHE G 114
ASP G 115
PRO G 185
ILE G  34
 None
 0.89A 4pcuA-5u0uG:
undetectable		 4pcuA-5u0uG:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		6 / 7 TYR G 111
SER G 175
TYR G 177
TYR G 190
GLU G 191
PRO G 196
 None
 1.06A 5aclA-5u0uG:
22.4		 5aclA-5u0uG:
78.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		5 / 12 GLY G  99
ILE G  34
TRP G 117
TYR G 116
VAL G   2
 None
 1.31A 5nz0A-5u0uG:
undetectable		 5nz0A-5u0uG:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.36A 5wauJ-5u0uG:
undetectable		 5wauJ-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.41A 5x1bW-5u0uG:
undetectable		 5x1bW-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		4 / 5 TYR G  95
MET G  93
THR G 121
LEU G 122
 None
 1.32A 5z86J-5u0uG:
undetectable		 5z86J-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		5 / 12 THR G  87
VAL G 125
VAL G 123
VAL G  68
TYR G  94
 None
 1.35A 6iblB-5u0uG:
undetectable		 6iblB-5u0uG:
18.85