SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Sulfolobus
solfataricus;
Human
immunodeficiency
virus
1) 		5 / 12 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.87A 1vptA-5u1cA:
undetectable		 1vptA-5u1cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Sulfolobus
solfataricus;
Human
immunodeficiency
virus
1) 		4 / 8 THR A 115
GLN A 137
ASP A 116
CYH A  65
 None
None
MG  A 501 (-2.8A)
None
 1.12A 2xz5A-5u1cA:
undetectable
2xz5C-5u1cA:
undetectable		 2xz5A-5u1cA:
19.33
2xz5C-5u1cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Sulfolobus
solfataricus;
Human
immunodeficiency
virus
1) 		4 / 8 THR A 115
GLN A 137
ASP A 116
CYH A  65
 None
None
MG  A 501 (-2.8A)
None
 1.10A 2xz5C-5u1cA:
undetectable
2xz5D-5u1cA:
undetectable		 2xz5C-5u1cA:
19.33
2xz5D-5u1cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 11 VAL A 165
ALA A 169
ILE A  73
LEU A 158
ILE A 162
 None
 1.00A 3clbA-5u1cA:
undetectable		 3clbA-5u1cA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 12 VAL A 165
ALA A 169
ILE A  73
LEU A 158
ILE A 162
 None
 0.93A 3clbC-5u1cA:
undetectable		 3clbC-5u1cA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 10 VAL A 165
ALA A 169
ILE A  73
LEU A 158
ILE A 162
 None
 1.00A 3hbbA-5u1cA:
undetectable		 3hbbA-5u1cA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 11 VAL A 165
ALA A 169
ILE A  73
LEU A 158
ILE A 162
 None
 0.98A 3hbbC-5u1cA:
undetectable		 3hbbC-5u1cA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		4 / 5 ASP A  64
ASP A 116
TYR A 143
PRO A 145
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
 0.51A 3l2uA-5u1cA:
12.2		 3l2uA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 7 ASP A  64
ASP A 116
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
 0.83A 3l2vA-5u1cA:
12.1		 3l2vA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		4 / 5 ASP A  64
ASP A 116
TYR A 143
PRO A 145
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
 0.56A 3l2wA-5u1cA:
17.9		 3l2wA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		6 / 8 ASP A  64
ASP A 116
PRO A 142
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
None
 0.78A 3oyaA-5u1cA:
18.0		 3oyaA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		7 / 8 ASP A  64
ASP A 116
GLY A 118
TYR A 143
PRO A 145
GLN A 146
ARG A 231
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
None
None
 0.98A 3s3mA-5u1cA:
11.5		 3s3mA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		6 / 8 ASP A  64
ASP A 116
GLY A 118
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
None
 0.68A 3s3nA-5u1cA:
10.5		 3s3nA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		5 / 7 ASP A  64
ASP A 116
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
 0.66A 3s3oA-5u1cA:
10.4		 3s3oA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		4 / 7 ASP A  64
TYR A 143
PRO A 145
ARG A 231
 MG  A 501 (-1.8A)
None
None
None
 1.12A 3s3oA-5u1cA:
10.4		 3s3oA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		4 / 5 SER A 119
GLY A 118
THR A  97
ASP A 116
 None
None
None
MG  A 501 (-2.8A)
 1.07A 4eohA-5u1cA:
undetectable		 4eohA-5u1cA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		4 / 6 ASP A  64
ASP A 116
ASN A 117
TYR A 143
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
 0.40A 4mdbA-5u1cA:
11.3		 4mdbA-5u1cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA
(Human
immunodeficiency
virus
1;
Sulfolobus
solfataricus) 		3 / 3 ASP A  64
ASP A 116
ASN A 144
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
 0.68A 4q5mA-5u1cA:
undetectable		 4q5mA-5u1cA:
21.36