SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		5 / 12 LEU B 164
ALA B 162
ALA B 207
LEU X   5
TYR A 408
 None
 1.18A 1cbrA-5u1dB:
undetectable		 1cbrA-5u1dB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		5 / 12 LEU B 164
ALA B 162
ALA B 207
LEU X   5
TYR A 408
 None
 1.18A 1cbrB-5u1dB:
undetectable		 1cbrB-5u1dB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens) 		3 / 3 MET B 389
LEU B 392
SER B 393
 None
 0.66A 1ee2A-5u1dB:
undetectable		 1ee2A-5u1dB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
(Homo
sapiens) 		5 / 10 LEU A 316
LEU A 317
THR A 328
THR A 331
THR A 446
 None
 1.22A 1i18A-5u1dA:
undetectable
1i18B-5u1dA:
undetectable		 1i18A-5u1dA:
9.50
1i18B-5u1dA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
(Homo
sapiens) 		5 / 10 THR A 446
LEU A 316
LEU A 317
THR A 328
THR A 331
 None
 1.21A 1i18A-5u1dA:
undetectable
1i18B-5u1dA:
undetectable		 1i18A-5u1dA:
9.50
1i18B-5u1dA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 SER B 254
ARG B 226
ASN B 222
ASP X  36
 None
 1.25A 1p6kB-5u1dB:
undetectable		 1p6kB-5u1dB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 SER B 254
ARG B 226
ASN B 222
ASP X  36
 None
 1.31A 1rs6B-5u1dB:
undetectable		 1rs6B-5u1dB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 SER B 254
ARG B 226
ASN B 222
ASP X  36
 None
 1.30A 1rs7B-5u1dB:
undetectable		 1rs7B-5u1dB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 SER B 254
ARG B 226
ASN B 222
ASP X  36
 None
 1.33A 1zzqB-5u1dB:
undetectable		 1zzqB-5u1dB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 SER B 254
ARG B 226
ASN B 222
ASP X  36
 None
 1.23A 1zzuB-5u1dB:
undetectable		 1zzuB-5u1dB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens) 		5 / 12 SER B 254
THR B 258
LEU B 223
ILE A 397
SER A 359
 None
 1.50A 2xrlA-5u1dB:
3.0		 2xrlA-5u1dB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE B 414
GLY B 407
VAL A 445
LEU B 392
 None
 0.92A 3elzA-5u1dB:
undetectable		 3elzA-5u1dB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens) 		5 / 10 ILE B 193
ALA B 192
PHE B 189
ALA B 188
VAL A 424
 None
 1.11A 3falA-5u1dB:
undetectable		 3falA-5u1dB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR A 455
LYS B 277
GLU A 459
 None
 0.86A 3ijdB-5u1dA:
undetectable		 3ijdB-5u1dA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		3 / 3 ASN B 267
ASP B 432
ARG X  37
 None
 0.76A 3k13C-5u1dB:
undetectable		 3k13C-5u1dB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1) 		3 / 3 SER A 412
ASP X   9
ASN B 269
 None
 0.92A 3lsfB-5u1dA:
undetectable
3lsfE-5u1dA:
undetectable		 3lsfB-5u1dA:
16.58
3lsfE-5u1dA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1) 		3 / 3 ASP X   9
ASN B 269
SER A 412
 None
 0.95A 3lsfB-5u1dX:
undetectable
3lsfE-5u1dX:
undetectable		 3lsfB-5u1dX:
18.91
3lsfE-5u1dX:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1) 		3 / 3 ASP X   9
ASN B 269
SER A 412
 None
 0.96A 3lslA-5u1dX:
undetectable
3lslD-5u1dX:
undetectable		 3lslA-5u1dX:
18.91
3lslD-5u1dX:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 5 LEU A 422
GLY A 419
PHE A 339
ASN X  14
 None
 0.93A 3uq6B-5u1dA:
undetectable		 3uq6B-5u1dA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PHE B 189
LEU A 427
GLY A 431
THR A 435
 None
 1.07A 3wrkD-5u1dB:
1.7		 3wrkD-5u1dB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 LEU B 259
ALA B 439
ASN X  30
ALA X   4
 None
 0.70A 4wboB-5u1dB:
undetectable		 4wboB-5u1dB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 5 THR X  21
GLU B 307
THR B 303
HIS B 299
 None
 1.07A 5utuH-5u1dX:
undetectable		 5utuH-5u1dX:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1) 		4 / 8 ASP A 297
GLU X  28
VAL A 460
GLN B 424
 None
 1.21A 6fbvD-5u1dA:
undetectable		 6fbvD-5u1dA:
21.65