SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		3 / 3 ALA A 187
VAL A 189
TRP A  58
 None
 0.97A 1av2A-5u1oA:
undetectable
1av2B-5u1oA:
undetectable		 1av2A-5u1oA:
12.50
1av2B-5u1oA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 6 GLY A 158
ILE A 159
PRO A 147
ILE A 265
 None
 0.91A 1n49D-5u1oA:
undetectable		 1n49D-5u1oA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 5 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.34A 1p6kB-5u1oA:
undetectable		 1p6kB-5u1oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 5 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.34A 1zzqB-5u1oA:
undetectable		 1zzqB-5u1oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  16
ALA A 142
GLY A 144
LEU A 140
LEU A 107
 None
FAD  A 501 (-4.4A)
FAD  A 501 (-3.4A)
None
None
 1.01A 2nyuB-5u1oA:
undetectable		 2nyuB-5u1oA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 8 TYR A 303
LEU A 140
LEU A 326
ALA A  27
 None
 1.07A 2wekA-5u1oA:
2.9		 2wekA-5u1oA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 10 ILE A 354
LEU A 199
LEU A 207
GLY A 180
ALA A 183
 None
 1.16A 2xf3A-5u1oA:
undetectable		 2xf3A-5u1oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		3 / 3 THR A 228
PRO A 227
THR A 197
 None
 0.91A 316dC-5u1oA:
undetectable		 316dC-5u1oA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  16
GLY A  20
ILE A  99
GLY A  44
GLY A  43
 None
None
None
FAD  A 501 (-3.2A)
None
 1.07A 3axzA-5u1oA:
undetectable		 3axzA-5u1oA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 8 VAL A 184
GLY A 188
PRO A 227
LYS A  55
 None
 0.90A 3bjwA-5u1oA:
undetectable		 3bjwA-5u1oA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  15
GLY A  17
GLU A  38
ALA A 119
ILE A 274
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.2A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.7A)
FAD  A 501 (-4.6A)
 0.94A 3fuuA-5u1oA:
3.5		 3fuuA-5u1oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 11 GLY A  15
GLY A  17
GLU A  38
ALA A 119
ILE A 274
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.2A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.7A)
FAD  A 501 (-4.6A)
 0.76A 3grvA-5u1oA:
3.4		 3grvA-5u1oA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 PRO A 353
GLY A 414
PRO A 206
VAL A 176
LEU A 199
 None
 0.98A 3m6wA-5u1oA:
undetectable		 3m6wA-5u1oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 ASP A 272
VAL A 127
ILE A  12
ILE A 289
ALA A 270
 None
 1.20A 3ohtA-5u1oA:
undetectable
3ohtB-5u1oA:
undetectable		 3ohtA-5u1oA:
20.70
3ohtB-5u1oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 164
ALA A 264
ALA A 187
THR A 197
 None
 1.10A 3t3sE-5u1oA:
undetectable		 3t3sE-5u1oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 8 LEU A  88
PHE A  83
VAL A 189
ALA A  64
 None
 0.57A 3uniB-5u1oA:
undetectable		 3uniB-5u1oA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 6 PRO A 147
GLY A  50
ALA A 264
GLN A  93
 None
FAD  A 501 (-3.4A)
None
None
 1.10A 4g0uA-5u1oA:
undetectable		 4g0uA-5u1oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 4 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.35A 4kcnB-5u1oA:
0.0		 4kcnB-5u1oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 11 GLY A 409
GLY A 358
LEU A 359
GLU A 363
HIS A 411
 None
 1.12A 4l8fB-5u1oA:
undetectable		 4l8fB-5u1oA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 11 GLY A 409
GLY A 358
LEU A 359
GLU A 363
HIS A 411
 None
 1.14A 4l8fD-5u1oA:
undetectable		 4l8fD-5u1oA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 TYR A 103
LYS A 116
GLY A  17
GLY A 323
ASN A  25
 None
None
FAD  A 501 (-3.2A)
None
None
 1.23A 4obwD-5u1oA:
undetectable		 4obwD-5u1oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 ALA A  24
SER A  23
GLY A  19
ILE A 274
ALA A 119
 None
None
FAD  A 501 (-3.7A)
FAD  A 501 (-4.6A)
FAD  A 501 (-3.7A)
 1.10A 4r29D-5u1oA:
undetectable		 4r29D-5u1oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 ILE A  99
GLY A  50
SER A  18
GLY A  43
LEU A  42
 None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.4A)
None
None
 1.06A 5i75A-5u1oA:
2.8		 5i75A-5u1oA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 142
GLY A 306
MET A 309
GLY A  20
SER A  23
 FAD  A 501 (-4.4A)
FAD  A 501 (-3.2A)
None
None
None
 1.34A 5jglB-5u1oA:
2.3		 5jglB-5u1oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 5 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.36A 5vunA-5u1oA:
undetectable		 5vunA-5u1oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 4 GLY A  60
GLN A  62
TRP A  58
VAL A 189
 None
 1.35A 5vunB-5u1oA:
0.0		 5vunB-5u1oA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5u1o GLUTATHIONE
REDUCTASE
(Vibrio
parahaemolyticus) 		4 / 8 TYR A 341
ILE A 313
ALA A 319
VAL A 320
 None
None
FAD  A 501 ( 4.0A)
None
 1.05A 6hu9a-5u1oA:
undetectable
6hu9e-5u1oA:
undetectable		 6hu9a-5u1oA:
21.70
6hu9e-5u1oA:
14.13