SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1065
SER A1077
SER A1080
VAL A1152
HIS A1112
 None
 1.08A 1db1A-5u1sA:
undetectable		 1db1A-5u1sA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 PRO A1198
LEU A1195
LEU A1326
LEU A1344
ASP A1343
 None
 1.26A 1e7wA-5u1sA:
undetectable		 1e7wA-5u1sA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 283
SER A 279
GLY A 371
TYR A 234
 None
 1.08A 1fapB-5u1sA:
3.8		 1fapB-5u1sA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5u1s SECURIN
SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 173
LEU A 119
ALA A 128
LEU A 166
LEU B 371
 None
 1.13A 1og5B-5u1sA:
undetectable		 1og5B-5u1sA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A1077
ASP A1172
LEU A1115
PRO A1114
TYR A1549
 None
 1.47A 1p33C-5u1sA:
2.0		 1p33C-5u1sA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1065
SER A1077
SER A1080
VAL A1152
HIS A1112
 None
 1.13A 1rk3A-5u1sA:
undetectable		 1rk3A-5u1sA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1264
LEU A1411
ILE A1171
LEU A1199
LEU A1197
 None
 1.13A 1s19A-5u1sA:
undetectable		 1s19A-5u1sA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1060
HIS A 970
ILE A 966
 None
 0.63A 1s9pB-5u1sA:
undetectable		 1s9pB-5u1sA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 386
VAL A 411
CYH A 318
ARG A 380
 None
 1.22A 1t46A-5u1sA:
undetectable		 1t46A-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 407
THR A 356
LEU A 360
LEU A 357
 None
 0.79A 1u18B-5u1sA:
undetectable		 1u18B-5u1sA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1344
ILE A1345
SER A 998
PHE A1296
LEU A1330
 None
 0.85A 1xdkB-5u1sA:
undetectable		 1xdkB-5u1sA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 279
LEU A 190
LEU A 209
LEU A 204
 None
 0.97A 2bfpD-5u1sA:
undetectable		 2bfpD-5u1sA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 272
SER A 279
GLN A 233
ASP A 418
 None
 1.16A 2cl5B-5u1sA:
undetectable		 2cl5B-5u1sA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 11 TYR A1622
MET A1536
GLY A1546
THR A1547
VAL A1620
 None
 1.45A 2cojA-5u1sA:
undetectable
2cojB-5u1sA:
undetectable		 2cojA-5u1sA:
12.27
2cojB-5u1sA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 571
LEU A 572
MET A 561
ARG A 560
 None
 1.33A 2gj5A-5u1sA:
undetectable		 2gj5A-5u1sA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A1528
LEU A1560
ILE A1626
SER A1597
 None
 0.95A 2hc4A-5u1sA:
undetectable		 2hc4A-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1416
PHE A1279
PHE A1410
ILE A1171
 None
 1.09A 2hjhA-5u1sA:
3.5		 2hjhA-5u1sA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 PHE A1584
SER A1477
LEU A1479
 None
 0.77A 2w1bA-5u1sA:
undetectable		 2w1bA-5u1sA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 363
GLU A 407
LEU A 404
TYR A 317
 None
 1.17A 2w8yA-5u1sA:
undetectable		 2w8yA-5u1sA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 272
SER A 279
GLN A 233
ASP A 418
 None
 1.08A 2zvjA-5u1sA:
undetectable		 2zvjA-5u1sA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5u1s SEPARIN
SECURIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ASN A1229
ARG B 265
GLY A1506
ILE A1503
PHE A1574
 None
 1.33A 3a25A-5u1sA:
undetectable		 3a25A-5u1sA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 PRO A1485
LEU A1490
ASN A1453
VAL A1559
LEU A1528
 None
 1.43A 3a51B-5u1sA:
2.2		 3a51B-5u1sA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A1077
ASP A1172
LEU A1115
PRO A1114
 None
 0.82A 3jq7B-5u1sA:
undetectable		 3jq7B-5u1sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 408
SER A 406
ILE A 389
PHE A 433
PHE A 444
 None
 1.28A 3ko0C-5u1sA:
undetectable
3ko0D-5u1sA:
undetectable
3ko0E-5u1sA:
undetectable
3ko0F-5u1sA:
undetectable		 3ko0C-5u1sA:
5.14
3ko0D-5u1sA:
5.14
3ko0E-5u1sA:
5.14
3ko0F-5u1sA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5u1s SEPARIN
SECURIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 THR A1567
THR A1231
VAL A1236
ILE A1240
ILE B 259
 None
 1.31A 3kpbD-5u1sA:
undetectable		 3kpbD-5u1sA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1539
GLN A 882
ILE A 888
LEU A 885
 None
 1.09A 3ls4L-5u1sA:
undetectable		 3ls4L-5u1sA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 186
SER A 192
ASN A 269
 None
 0.88A 3s8pB-5u1sA:
2.5		 3s8pB-5u1sA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 6 SER A1183
LEU A1185
THR A1170
ARG A1111
 None
 0.95A 3thrB-5u1sA:
undetectable		 3thrB-5u1sA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1109
HIS A1112
MET A1113
 None
 0.90A 3thrD-5u1sA:
undetectable		 3thrD-5u1sA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1361
ASP A1350
ASP A1343
 None
 0.85A 4a6eA-5u1sA:
undetectable		 4a6eA-5u1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN A1510
GLY A1530
PHE A1500
THR A1547
ILE A1548
 None
 1.15A 4hytA-5u1sA:
5.1		 4hytA-5u1sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN A1510
GLY A1530
PHE A1500
THR A1547
ILE A1548
 None
 1.14A 4hytC-5u1sA:
undetectable		 4hytC-5u1sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1120
ILE A 785
GLY A 788
ILE A1143
SER A 792
 None
 0.93A 4iv0A-5u1sA:
undetectable		 4iv0A-5u1sA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 4 SER A1398
ILE A1548
TYR A1538
PRO A1420
 None
 1.37A 4jkuB-5u1sA:
undetectable		 4jkuB-5u1sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 4 SER A1398
ILE A1548
TYR A1538
PRO A1420
 None
 1.37A 4kadA-5u1sA:
undetectable		 4kadA-5u1sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 4 SER A1398
ILE A1548
TYR A1538
PRO A1420
 None
 1.38A 4kadB-5u1sA:
0.8		 4kadB-5u1sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1323
ILE A1324
LEU A1369
LEU A1373
 None
 1.01A 4l1wA-5u1sA:
undetectable		 4l1wA-5u1sA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 8 HIS A1112
ASP A1108
ALA A1155
SER A1421
 None
 0.96A 4l7iB-5u1sA:
undetectable		 4l7iB-5u1sA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1422
ARG A1111
SER A1421
 None
 1.21A 4lf7I-5u1sA:
undetectable
4lf7J-5u1sA:
undetectable		 4lf7I-5u1sA:
6.02
4lf7J-5u1sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1422
ARG A1111
SER A1421
 None
 1.21A 4lf8I-5u1sA:
undetectable
4lf8J-5u1sA:
undetectable		 4lf8I-5u1sA:
6.02
4lf8J-5u1sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 112
ASN A 137
ILE A 116
LEU A 127
ALA A 170
 None
 1.44A 4m83A-5u1sA:
undetectable		 4m83A-5u1sA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1120
ILE A 785
GLY A 788
ILE A1143
SER A 792
 None
 0.97A 4mwzB-5u1sA:
undetectable		 4mwzB-5u1sA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1528
GLY A1507
THR A1550
ILE A1517
GLN A1510
 None
 1.04A 4o5fA-5u1sA:
2.4
4o5fB-5u1sA:
undetectable		 4o5fA-5u1sA:
9.41
4o5fB-5u1sA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN A1510
LEU A1528
GLY A1507
THR A1550
ILE A1517
 None
 1.03A 4o5fA-5u1sA:
2.5
4o5fB-5u1sA:
undetectable		 4o5fA-5u1sA:
9.41
4o5fB-5u1sA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1429
SER A1162
VAL A1168
LEU A1624
LEU A1164
 None
 1.28A 4or0B-5u1sA:
5.1		 4or0B-5u1sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 PRO A1625
LEU A1624
GLN A1435
 None
 0.54A 4pevB-5u1sA:
2.8		 4pevB-5u1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1618
ILE A1225
ILE A1267
LEU A1264
MET A1260
 None
 1.17A 4r3aA-5u1sA:
undetectable		 4r3aA-5u1sA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU A1543
GLY A 841
TYR A1539
TYR A1538
ILE A 840
 None
 1.48A 4xudA-5u1sA:
undetectable		 4xudA-5u1sA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A 722
ASN A 681
LEU A 814
ASN A 650
GLU A 685
 None
 1.42A 4zjlD-5u1sA:
1.0		 4zjlD-5u1sA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 ASP A1572
ILE A1571
GLY A1530
THR A1459
 None
 1.04A 4zxiA-5u1sA:
undetectable		 4zxiA-5u1sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1528
GLY A1507
THR A1550
ILE A1517
GLN A1510
 None
 1.07A 5b8hA-5u1sA:
undetectable
5b8hB-5u1sA:
3.5		 5b8hA-5u1sA:
10.20
5b8hB-5u1sA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 12 GLN A1510
LEU A1528
GLY A1507
THR A1550
ILE A1517
 None
 1.03A 5b8hA-5u1sA:
4.0
5b8hB-5u1sA:
3.5		 5b8hA-5u1sA:
10.20
5b8hB-5u1sA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 186
SER A 192
ASN A 269
 None
 0.88A 5cprB-5u1sA:
undetectable		 5cprB-5u1sA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1490
ILE A1523
PHE A1500
VAL A1501
GLU A1509
 None
 1.20A 5igzA-5u1sA:
undetectable		 5igzA-5u1sA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 461
ASP A 502
ARG A 500
ASN A 460
 None
 1.07A 5l6eA-5u1sA:
2.2		 5l6eA-5u1sA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 975
TRP A 973
SER A 978
 None
 1.24A 5nwwA-5u1sA:
undetectable		 5nwwA-5u1sA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 7 THR A1170
LEU A1394
VAL A1620
TYR A1622
 None
 1.11A 5ov9A-5u1sA:
undetectable		 5ov9A-5u1sA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 ARG A1606
PHE A1403
LEU A1264
LEU A1394
 None
 1.17A 5veuH-5u1sA:
undetectable		 5veuH-5u1sA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 596
PHE A 641
ASN A 653
TYR A 648
 None
 1.19A 6a93B-5u1sA:
undetectable		 6a93B-5u1sA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5u1s SEPARIN
SECURIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 GLY A1506
GLN B 266
TYR A1511
TYR A1502
 None
 1.28A 6ag0A-5u1sA:
undetectable		 6ag0A-5u1sA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5u1s SEPARIN
SECURIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 GLY A1506
GLN B 266
TYR A1511
TYR A1502
 None
 1.22A 6ag0C-5u1sA:
undetectable		 6ag0C-5u1sA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 9 SER A1233
SER A1532
SER A1533
GLY A1506
THR A1459
 None
 1.16A 6awpA-5u1sA:
undetectable		 6awpA-5u1sA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 PHE A1337
ASP A1336
LYS A1340
 None
 0.70A 6awtD-5u1sA:
undetectable		 6awtD-5u1sA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 850
LYS A 851
SER A 854
 None
 0.82A 6az3P-5u1sA:
undetectable		 6az3P-5u1sA:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 586
HIS A 100
TYR A 590
SER A 635
VAL A 540
 None
 1.32A 6b89B-5u1sA:
0.3		 6b89B-5u1sA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 939
TYR A 691
THR A 907
ASN A 726
 None
 1.14A 6c71B-5u1sA:
undetectable		 6c71B-5u1sA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 5u1s SEPARIN
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 655
ALA A 902
SER A 908
PHE A 930
 None
 1.46A 6cm4A-5u1sA:
2.4		 6cm4A-5u1sA:
13.92