SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.38A 1a4gA-5u22A:
undetectable		 1a4gA-5u22A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.36A 1a4gB-5u22A:
undetectable		 1a4gB-5u22A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 4 VAL A 158
TRP A 160
TRP A 118
 None
None
BTB  A 501 (-3.6A)
 1.34A 1gmkC-5u22A:
undetectable
1gmkD-5u22A:
undetectable		 1gmkC-5u22A:
4.12
1gmkD-5u22A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 8 MET A 201
ALA A 219
ILE A 218
ASN A 253
 None
 1.12A 1pnlA-5u22A:
undetectable
1pnlB-5u22A:
undetectable		 1pnlA-5u22A:
19.72
1pnlB-5u22A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 10 GLY A 298
PHE A 290
GLY A 264
THR A 287
HIS A 260
 None
EDO  A 502 (-4.3A)
None
BTB  A 501 (-4.1A)
EDO  A 502 (-3.8A)
 1.24A 1pwyE-5u22A:
undetectable		 1pwyE-5u22A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 GLU A 155
ASN A 154
TRP A 118
 BTB  A 501 (-2.8A)
BTB  A 501 (-3.4A)
BTB  A 501 (-3.6A)
 1.10A 1r15C-5u22A:
undetectable		 1r15C-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 GLU A 155
ASN A 154
TRP A 118
 BTB  A 501 (-2.8A)
BTB  A 501 (-3.4A)
BTB  A 501 (-3.6A)
 1.06A 1r15D-5u22A:
undetectable		 1r15D-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 GLU A 155
ASN A 154
TRP A 118
 BTB  A 501 (-2.8A)
BTB  A 501 (-3.4A)
BTB  A 501 (-3.6A)
 1.07A 1r15E-5u22A:
undetectable		 1r15E-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 GLU A 155
ASN A 154
TRP A 118
 BTB  A 501 (-2.8A)
BTB  A 501 (-3.4A)
BTB  A 501 (-3.6A)
 1.03A 1r15F-5u22A:
undetectable		 1r15F-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 10 GLY A 298
PHE A 290
GLY A 264
THR A 287
HIS A 260
 None
EDO  A 502 (-4.3A)
None
BTB  A 501 (-4.1A)
EDO  A 502 (-3.8A)
 1.33A 1v3qE-5u22A:
undetectable		 1v3qE-5u22A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 6 ARG A 275
PHE A 272
ARG A 271
GLU A 222
 None
 1.31A 2c8aC-5u22A:
undetectable		 2c8aC-5u22A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 5 ASP A 304
LEU A  55
GLY A 295
ARG A  98
 None
 1.17A 2j2pA-5u22A:
undetectable
2j2pB-5u22A:
undetectable		 2j2pA-5u22A:
20.75
2j2pB-5u22A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 4 ASP A 304
LEU A  55
GLY A 295
ARG A  98
 None
 1.20A 2j2pD-5u22A:
undetectable
2j2pE-5u22A:
undetectable		 2j2pD-5u22A:
20.75
2j2pE-5u22A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 10 ILE A 411
ILE A 428
LEU A 369
ASN A 368
VAL A 343
 None
 1.21A 2nnhB-5u22A:
undetectable		 2nnhB-5u22A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ILE A 217
TYR A 148
THR A 251
TYR A 236
TRP A 172
 None
 1.17A 3a8iC-5u22A:
undetectable		 3a8iC-5u22A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 6 LEU A 239
GLU A 198
ASN A 199
SER A 242
 None
EDO  A 503 (-4.9A)
IOD  A 508 ( 4.4A)
None
 1.34A 3i9jB-5u22A:
undetectable		 3i9jB-5u22A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 8 GLY A 264
PHE A 233
PHE A 272
PHE A 276
 None
 1.07A 3ko0D-5u22A:
undetectable
3ko0E-5u22A:
undetectable		 3ko0D-5u22A:
12.77
3ko0E-5u22A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.41A 4cpnA-5u22A:
undetectable		 4cpnA-5u22A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.44A 4cpzA-5u22A:
undetectable		 4cpzA-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.40A 4cpzB-5u22A:
undetectable		 4cpzB-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.39A 4cpzC-5u22A:
undetectable		 4cpzC-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.38A 4cpzD-5u22A:
undetectable		 4cpzD-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.38A 4cpzG-5u22A:
undetectable		 4cpzG-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ALA A 219
GLU A 151
GLU A 110
ARG A  76
ASN A 253
 None
 1.39A 4cpzH-5u22A:
undetectable		 4cpzH-5u22A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ASN A 333
SER A 334
ARG A 275
LEU A 336
ILE A 337
 None
 1.38A 4k36A-5u22A:
3.2		 4k36A-5u22A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 11 ASN A 333
SER A 334
ARG A 275
LEU A 336
ILE A 337
 None
 1.35A 4k37B-5u22A:
2.6		 4k37B-5u22A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 TYR A 349
ARG A 425
SER A 351
 None
 0.98A 4khpI-5u22A:
undetectable
4khpJ-5u22A:
undetectable		 4khpI-5u22A:
15.84
4khpJ-5u22A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 LEU A 111
ILE A 114
ARG A  80
 None
 0.61A 4mk4B-5u22A:
undetectable		 4mk4B-5u22A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 ILE A 109
ASP A 183
ARG A  80
 None
 0.63A 4pstA-5u22A:
undetectable		 4pstA-5u22A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 6 LEU A  55
LEU A  66
VAL A  67
ARG A  98
 None
 1.25A 4uswA-5u22A:
undetectable		 4uswA-5u22A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 5 TYR A 317
GLY A 284
TYR A 314
GLY A 298
 None
 0.97A 5ayfA-5u22A:
undetectable		 5ayfA-5u22A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 ARG A 425
LYS A 380
GLU A 382
 None
 0.80A 5d0yA-5u22A:
undetectable		 5d0yA-5u22A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 PRO A  69
LEU A 300
SER A  65
 None
 0.84A 5fsaB-5u22A:
undetectable		 5fsaB-5u22A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 8 SER A 342
THR A 321
ARG A 425
ILE A 353
 None
 1.12A 5jhdE-5u22A:
undetectable
5jhdG-5u22A:
undetectable		 5jhdE-5u22A:
19.43
5jhdG-5u22A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 VAL A  74
GLU A 110
GLU A 151
 None
 0.92A 5jsdB-5u22A:
undetectable
5jsdC-5u22A:
undetectable		 5jsdB-5u22A:
24.60
5jsdC-5u22A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 LYS A  64
ASP A  62
ARG A  98
 None
 1.06A 5jwaA-5u22A:
undetectable
5jwaH-5u22A:
undetectable		 5jwaA-5u22A:
22.49
5jwaH-5u22A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5u22 N2152
(Neocallimastix
frontalis) 		5 / 12 ILE A 189
GLY A 149
VAL A 107
ILE A 250
ALA A 219
 None
 1.10A 5n0tA-5u22A:
undetectable		 5n0tA-5u22A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5u22 N2152
(Neocallimastix
frontalis) 		3 / 3 TYR A 427
ALA A 347
TYR A 349
 None
 0.80A 5uunB-5u22A:
undetectable		 5uunB-5u22A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5u22 N2152
(Neocallimastix
frontalis) 		4 / 9 ILE A 399
TYR A 424
ILE A 426
ILE A 428
 IOD  A 509 ( 4.9A)
None
None
None
 0.76A 5vkqB-5u22A:
undetectable
5vkqC-5u22A:
undetectable		 5vkqB-5u22A:
12.96
5vkqC-5u22A:
12.96