SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 9 LEU A 531
GLU A 548
LYS A 489
ILE A 525
VAL A 471
 None
 1.45A 1gx8A-5u2aA:
undetectable		 1gx8A-5u2aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 11 LEU A 531
GLU A 548
LYS A 489
ILE A 525
VAL A 471
 None
 1.43A 1gx9A-5u2aA:
undetectable		 1gx9A-5u2aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 TYR A 228
GLY A 259
ALA A 224
MET A 229
GLY A 252
 None
 1.08A 1kiaA-5u2aA:
2.2		 1kiaA-5u2aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 TYR A 228
GLY A 259
ALA A 224
MET A 229
GLY A 252
 None
 1.07A 1kiaB-5u2aA:
undetectable		 1kiaB-5u2aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 TYR A 228
GLY A 259
ALA A 224
MET A 229
GLY A 252
 None
 1.07A 1kiaC-5u2aA:
undetectable		 1kiaC-5u2aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 GLY A  80
ILE A  88
THR A 107
GLU A 103
ALA A 185
 None
 1.04A 1nv8B-5u2aA:
2.6		 1nv8B-5u2aA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 GLY A 259
VAL A 233
LEU A 109
PHE A 241
ASN A 243
 None
 1.22A 1nw3A-5u2aA:
2.8		 1nw3A-5u2aA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 10 ALA A 184
ALA A 181
VAL A 143
MET A  82
LEU A  83
 None
 1.33A 1rlbE-5u2aA:
undetectable		 1rlbE-5u2aA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 5 ALA A 370
TYR A 372
ILE A 439
ASP A 436
 None
 1.10A 1upfA-5u2aA:
undetectable		 1upfA-5u2aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 5 ALA A 370
TYR A 372
ILE A 439
ASP A 436
 None
 1.17A 1upfC-5u2aA:
3.1		 1upfC-5u2aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 PRO A 247
VAL A  79
ILE A 108
VAL A 143
LEU A  83
 None
 1.34A 1z9hA-5u2aA:
2.1		 1z9hA-5u2aA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 PRO A 247
VAL A  79
ILE A 108
VAL A 143
LEU A  83
 None
 1.36A 1z9hB-5u2aA:
2.2		 1z9hB-5u2aA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 PRO A 247
VAL A  79
ILE A 108
VAL A 143
LEU A  83
 None
 1.35A 1z9hC-5u2aA:
2.2		 1z9hC-5u2aA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 7 PRO A 120
MET A 201
ARG A 133
GLY A 214
 None
 1.15A 2hs1B-5u2aA:
undetectable		 2hs1B-5u2aA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 LEU A 406
LEU A 222
MET A 374
MET A 229
 None
 1.43A 2oaxB-5u2aA:
undetectable		 2oaxB-5u2aA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		3 / 3 ASP A 429
THR A 534
PRO A 535
 None
 0.66A 2q64B-5u2aA:
undetectable		 2q64B-5u2aA:
11.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 9 ALA A 250
TYR A 251
ALA A 322
GLY A 323
GLY A 347
 None
 0.68A 2v7bA-5u2aA:
44.8		 2v7bA-5u2aA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 9 ALA A 250
TYR A 251
ALA A 322
GLY A 323
GLY A 347
 None
 0.67A 2v7bB-5u2aA:
44.6		 2v7bB-5u2aA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 8 GLY A 323
GLY A 347
GLN A 348
THR A 349
 None
 0.57A 2wd9B-5u2aA:
44.2		 2wd9B-5u2aA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 ILE A 114
GLY A  80
ALA A 185
ALA A 106
ALA A  86
 None
 1.05A 3jb3A-5u2aA:
undetectable		 3jb3A-5u2aA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 10 ASP A 246
LEU A 269
VAL A 105
ILE A 108
TYR A 118
 None
 1.10A 3kz7A-5u2aA:
undetectable		 3kz7A-5u2aA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		3 / 3 ASP A 429
THR A 534
PRO A 535
 None
 0.65A 3tkgD-5u2aA:
undetectable		 3tkgD-5u2aA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 7 PRO A 120
MET A 201
ARG A 133
GLY A 214
 None
 1.16A 3ucbB-5u2aA:
undetectable		 3ucbB-5u2aA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 ILE A 449
LEU A 466
ILE A 539
LEU A 531
VAL A 528
 None
 1.12A 3w68B-5u2aA:
undetectable		 3w68B-5u2aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 5 ARG A 541
VAL A 461
LEU A 465
SER A 463
 None
 1.26A 4e1gA-5u2aA:
undetectable		 4e1gA-5u2aA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 7 ALA A 250
TYR A 251
ALA A 322
GLY A 323
 None
 0.49A 4eatA-5u2aA:
43.0		 4eatA-5u2aA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 7 TYR A 251
ALA A 322
GLY A 323
GLY A 347
 None
 0.54A 4eatA-5u2aA:
43.0		 4eatA-5u2aA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 9 ALA A 250
TYR A 251
ALA A 322
GLY A 323
GLY A 347
 None
 0.73A 4eatB-5u2aA:
43.0		 4eatB-5u2aA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 8 TYR A 425
ASP A 429
VAL A 379
LEU A 351
 None
 0.97A 4f8hA-5u2aA:
undetectable
4f8hB-5u2aA:
undetectable		 4f8hA-5u2aA:
20.56
4f8hB-5u2aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 8 TYR A 425
ASP A 429
VAL A 379
LEU A 351
 None
 0.95A 4f8hD-5u2aA:
undetectable
4f8hE-5u2aA:
undetectable		 4f8hD-5u2aA:
20.56
4f8hE-5u2aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 5 ASN A 243
ALA A 245
GLY A 252
ASP A 429
 None
 0.97A 4n48A-5u2aA:
1.7		 4n48A-5u2aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 10 LEU A 171
LEU A 165
ASN A 145
VAL A 143
LEU A  98
 None
 1.05A 4po0A-5u2aA:
undetectable		 4po0A-5u2aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 ILE A 240
LEU A  55
ALA A  54
ILE A  58
LEU A  64
 None
 1.01A 4psyA-5u2aA:
undetectable		 4psyA-5u2aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 7 LEU A 262
LEU A  29
ASN A  38
ILE A  37
 None
 0.60A 4rmjA-5u2aA:
3.0		 4rmjA-5u2aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 ASN A 243
SER A 294
ALA A 292
VAL A 319
 None
 1.39A 4x1kC-5u2aA:
undetectable		 4x1kC-5u2aA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 ASN A 392
SER A 536
ARG A 366
PRO A 535
 None
 1.37A 5b2oA-5u2aA:
0.7		 5b2oA-5u2aA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_B_ACTB120_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 ASN A 392
SER A 536
ARG A 366
PRO A 535
 None
 1.36A 5b2pA-5u2aA:
0.0		 5b2pA-5u2aA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		3 / 3 VAL A 448
THR A 450
ARG A 455
 None
 0.59A 5b2sB-5u2aA:
undetectable		 5b2sB-5u2aA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		3 / 3 VAL A 448
THR A 450
ARG A 455
 None
 0.59A 5b2tB-5u2aA:
undetectable		 5b2tB-5u2aA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 11 ASP A 246
LEU A 269
VAL A 105
ILE A 108
TYR A 118
 None
 1.05A 5gpgA-5u2aA:
undetectable		 5gpgA-5u2aA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 8 ASN A 357
ALA A 370
HIS A 358
HIS A 363
 None
 1.16A 5km8A-5u2aA:
undetectable
5km8B-5u2aA:
undetectable		 5km8A-5u2aA:
12.95
5km8B-5u2aA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 10 TRP A 249
GLY A  96
TYR A 118
PHE A 125
ILE A 130
 None
 1.41A 5lbtA-5u2aA:
3.1
5lbtB-5u2aA:
2.2		 5lbtA-5u2aA:
16.81
5lbtB-5u2aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 THR A 144
VAL A 161
PRO A 172
THR A 163
 None
 1.39A 5mthA-5u2aA:
undetectable
5mthH-5u2aA:
undetectable		 5mthA-5u2aA:
16.52
5mthH-5u2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 VAL A 288
LEU A 316
GLY A 293
SER A 294
ILE A 244
 None
 0.97A 5vooD-5u2aA:
undetectable		 5vooD-5u2aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		5 / 12 VAL A 288
LEU A 316
GLY A 293
SER A 294
ILE A 244
 None
 1.01A 5vooF-5u2aA:
3.2		 5vooF-5u2aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 LEU A 146
ASP A 175
PRO A 172
ARG A 149
 None
 1.39A 6fgdA-5u2aA:
4.6		 6fgdA-5u2aA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Brucella
canis) 		4 / 4 LEU A 269
ASP A 246
PRO A 247
ARG A 100
 None
 1.43A 6fgdA-5u2aA:
4.6		 6fgdA-5u2aA:
24.79