SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		4 / 6 GLY A 112
PRO A  95
LYS A  94
THR A  93
 None
 1.02A 2m2oB-5u2iA:
undetectable		 2m2oB-5u2iA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 1.03A 2oxtA-5u2iA:
undetectable		 2oxtA-5u2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 0.97A 2oxtC-5u2iA:
undetectable		 2oxtC-5u2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 10 ALA A  86
ILE A  90
ILE A 115
LEU A  10
ILE A  23
 None
 1.12A 4dtaA-5u2iA:
undetectable		 4dtaA-5u2iA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		4 / 7 GLY A 118
ALA A 125
SER A 119
GLU A   4
 None
 0.92A 4hyfA-5u2iA:
undetectable		 4hyfA-5u2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		4 / 8 GLY A 118
ALA A 125
SER A 119
GLU A   4
 None
 0.92A 4hyfB-5u2iA:
undetectable		 4hyfB-5u2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 GLY A  21
ILE A  23
ILE A  40
PRO A  12
LEU A  67
 None
 0.96A 5e72A-5u2iA:
undetectable		 5e72A-5u2iA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 ALA A  86
GLY A  81
ILE A 116
ASP A 106
GLY A 101
 None
 1.22A 5wwsB-5u2iA:
undetectable		 5wwsB-5u2iA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 ALA A  14
THR A  93
ILE A   8
ALA A   9
ILE A  90
 None
 1.31A 5xiwD-5u2iA:
undetectable		 5xiwD-5u2iA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u2i NUCLEOSIDE
DIPHOSPHATE KINASE
(Naegleria
fowleri) 		5 / 12 LEU A  10
ILE A  24
GLN A  29
ILE A 149
MET A  75
 None
 0.96A 5y2tB-5u2iA:
undetectable		 5y2tB-5u2iA:
undetectable