SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ASP A 474
GLY A 122
PHE A 123
TYR A 471
 None
 0.85A 2aouA-5u2nA:
2.6		 2aouA-5u2nA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 7 PHE A 193
ARG A 196
ASP A 219
ALA A 244
ARG A 311
 7TA  A 504 (-3.6A)
SO4  A 501 ( 3.2A)
7TA  A 504 (-3.3A)
7TA  A 504 (-3.5A)
SO4  A 501 ( 3.2A)
 0.29A 2e5dA-5u2nA:
58.8
2e5dB-5u2nA:
58.6		 2e5dA-5u2nA:
100.00
2e5dB-5u2nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 7 PHE A 193
ARG A 196
ASP A 219
ALA A 244
ARG A 311
 7TA  A 504 (-3.6A)
SO4  A 501 ( 3.2A)
7TA  A 504 (-3.3A)
7TA  A 504 (-3.5A)
SO4  A 501 ( 3.2A)
 0.19A 2e5dA-5u2nA:
58.8
2e5dB-5u2nA:
58.6		 2e5dA-5u2nA:
100.00
2e5dB-5u2nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 6 VAL A 130
PHE A 440
PRO A 126
THR A  57
 None
 1.34A 2q6oB-5u2nA:
undetectable		 2q6oB-5u2nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A  37
PHE A 132
GLY A  61
ILE A 206
 None
 0.97A 2qwxA-5u2nA:
undetectable
2qwxB-5u2nA:
undetectable		 2qwxA-5u2nA:
19.21
2qwxB-5u2nA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 6 LEU A 325
LEU A 328
ILE A 378
ARG A 349
 None
 1.04A 2rlfA-5u2nA:
undetectable
2rlfB-5u2nA:
undetectable		 2rlfA-5u2nA:
7.25
2rlfB-5u2nA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 6 LEU A 325
LEU A 328
ILE A 378
ARG A 349
 None
 0.97A 2rlfC-5u2nA:
undetectable
2rlfD-5u2nA:
undetectable		 2rlfC-5u2nA:
7.25
2rlfD-5u2nA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ILE A 159
TYR A  54
VAL A 161
CYH A 397
 None
 1.21A 2xz5A-5u2nA:
undetectable
2xz5C-5u2nA:
undetectable		 2xz5A-5u2nA:
19.32
2xz5C-5u2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ILE A 159
TYR A  54
VAL A 161
CYH A 397
 None
 1.21A 2xz5C-5u2nA:
undetectable
2xz5D-5u2nA:
undetectable		 2xz5C-5u2nA:
19.32
2xz5D-5u2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		3 / 3 SER A 314
GLU A 258
ASP A 294
 None
 0.60A 2zulA-5u2nA:
undetectable		 2zulA-5u2nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 THR A 218
ARG A 477
LEU A 386
SER A 209
 None
 0.87A 2zw9A-5u2nA:
undetectable		 2zw9A-5u2nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		3 / 3 ARG A 424
VAL A 130
THR A 442
 None
 0.77A 3cyxA-5u2nA:
undetectable		 3cyxA-5u2nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		3 / 3 SER A 314
GLU A 258
ASP A 294
 None
 0.64A 3dmhA-5u2nA:
undetectable		 3dmhA-5u2nA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 SER A 200
ALA A 204
GLY A 223
TYR A  64
GLY A 207
 None
 1.06A 3f8wA-5u2nA:
undetectable		 3f8wA-5u2nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 SER A 200
ALA A 204
GLY A 223
TYR A  64
GLY A 207
 None
 1.05A 3f8wC-5u2nA:
undetectable		 3f8wC-5u2nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 11 ALA A  83
ILE A  80
ILE A 104
LEU A 144
ILE A  11
 None
 1.03A 3hbbC-5u2nA:
undetectable		 3hbbC-5u2nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 7 VAL A 461
LYS A 469
TYR A 471
PRO A 120
 None
 1.26A 3hs4A-5u2nA:
undetectable		 3hs4A-5u2nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.39A 3jx1A-5u2nA:
undetectable
3jx1B-5u2nA:
undetectable		 3jx1A-5u2nA:
20.37
3jx1B-5u2nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.35A 3nlyA-5u2nA:
undetectable
3nlyB-5u2nA:
undetectable		 3nlyA-5u2nA:
20.57
3nlyB-5u2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.36A 3rqlA-5u2nA:
undetectable
3rqlB-5u2nA:
undetectable		 3rqlA-5u2nA:
20.57
3rqlB-5u2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 385
ASN A 164
GLY A 194
ASP A 192
 None
 1.31A 3ztvA-5u2nA:
1.9		 3ztvA-5u2nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.37A 4capA-5u2nA:
undetectable
4capB-5u2nA:
undetectable		 4capA-5u2nA:
20.57
4capB-5u2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.37A 4d32A-5u2nA:
undetectable
4d32B-5u2nA:
undetectable		 4d32A-5u2nA:
20.57
4d32B-5u2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 TYR A  36
ILE A 206
SER A 155
GLY A  61
LEU A  62
 None
 1.10A 4e1gB-5u2nA:
undetectable		 4e1gB-5u2nA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		7 / 8 PHE A 193
ARG A 196
ASP A 219
SER A 241
ALA A 244
SER A 275
ARG A 311
 7TA  A 504 (-3.6A)
SO4  A 501 ( 3.2A)
7TA  A 504 (-3.3A)
7TA  A 504 ( 3.8A)
7TA  A 504 (-3.5A)
7TA  A 504 (-2.7A)
SO4  A 501 ( 3.2A)
 0.24A 4lv9A-5u2nA:
58.7
4lv9B-5u2nA:
58.1		 4lv9A-5u2nA:
100.00
4lv9B-5u2nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		6 / 7 PHE A 193
ASP A 219
SER A 241
ALA A 244
SER A 275
ARG A 311
 7TA  A 504 (-3.6A)
7TA  A 504 (-3.3A)
7TA  A 504 ( 3.8A)
7TA  A 504 (-3.5A)
7TA  A 504 (-2.7A)
SO4  A 501 ( 3.2A)
 0.23A 4lv9A-5u2nA:
58.7
4lv9B-5u2nA:
58.1		 4lv9A-5u2nA:
100.00
4lv9B-5u2nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		7 / 7 TYR A 188
HIS A 191
VAL A 242
ILE A 309
ARG A 349
ILE A 351
ALA A 379
 None
7TA  A 504 (-3.6A)
7TA  A 504 (-4.3A)
7TA  A 504 (-4.4A)
None
7TA  A 504 (-4.1A)
7TA  A 504 (-3.7A)
 0.21A 4lv9B-5u2nA:
58.1		 4lv9B-5u2nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A  37
PHE A 132
GLY A  61
ILE A 206
 None
 0.87A 4qoiA-5u2nA:
undetectable
4qoiB-5u2nA:
undetectable		 4qoiA-5u2nA:
19.21
4qoiB-5u2nA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 PHE A 132
GLU A  38
SER A 398
VAL A 153
 None
None
SO4  A 502 (-2.8A)
None
 1.36A 4v3yA-5u2nA:
undetectable
4v3yB-5u2nA:
undetectable		 4v3yA-5u2nA:
20.57
4v3yB-5u2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 11 ASP A 138
ASP A 109
TYR A 108
GLY A 100
GLY A 110
 None
 1.26A 4xp4A-5u2nA:
undetectable		 4xp4A-5u2nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ASP A 256
TYR A 281
GLU A 258
ILE A 290
 None
 1.05A 5cfsA-5u2nA:
undetectable		 5cfsA-5u2nA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 SER A 398
VAL A 153
PHE A 132
GLU A  38
 SO4  A 502 (-2.8A)
None
None
None
 1.32A 5uo7A-5u2nA:
undetectable
5uo7B-5u2nA:
undetectable		 5uo7A-5u2nA:
20.81
5uo7B-5u2nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A  70
TRP A 147
TRP A 143
ASN A  10
ILE A 104
 None
 1.34A 6qxsD-5u2nA:
undetectable		 6qxsD-5u2nA:
19.96