SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 LEU A 285
ALA A 366
ALA A 362
TYR A 331
GLN A 282
 None
 1.32A 1hbpA-5u2oA:
undetectable		 1hbpA-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 LEU A 285
ALA A 366
ALA A 362
TYR A 331
GLN A 282
 None
 1.26A 1iiuA-5u2oA:
undetectable		 1iiuA-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 ALA A 255
ALA A 159
LEU A 178
GLY A 259
LEU A 196
 None
 1.18A 1qabF-5u2oA:
undetectable		 1qabF-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 SER A 410
ASP A 405
GLU A 413
MET A 415
ALA A 437
 None
 1.34A 1s14B-5u2oA:
undetectable		 1s14B-5u2oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 VAL A 221
VAL A 138
GLU A 203
ARG A 239
ASP A 118
 None
 1.13A 1t6zA-5u2oA:
undetectable		 1t6zA-5u2oA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 TYR A 331
GLY A 215
PHE A 252
ARG A 280
 None
 1.37A 2a3cA-5u2oA:
undetectable		 2a3cA-5u2oA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 ILE A 200
ALA A 160
GLN A 161
LEU A 164
ALA A 530
 None
 1.12A 2aclE-5u2oA:
undetectable		 2aclE-5u2oA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 VAL A 400
LEU A 401
GLY A 416
ALA A 418
LEU A 421
 None
 1.03A 2aylA-5u2oA:
undetectable		 2aylA-5u2oA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 LEU A  95
VAL A 100
GLY A  99
CYH A 114
LEU A 184
 None
None
None
ZN  A 606 (-2.3A)
None
 1.33A 2bxeA-5u2oA:
undetectable		 2bxeA-5u2oA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 LEU A  95
VAL A 100
GLY A  99
CYH A 114
LEU A 184
 None
None
None
ZN  A 606 (-2.3A)
None
 1.28A 2bxeB-5u2oA:
undetectable		 2bxeB-5u2oA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 TRP A 352
ASN A 300
GLN A 299
PRO A 153
 GOL  A 603 (-3.9A)
None
None
None
 1.32A 2ez7A-5u2oA:
undetectable		 2ez7A-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		3 / 3 GLU A 203
ASP A 527
TYR A 306
 None
GOL  A 603 ( 4.5A)
GOL  A 603 ( 4.2A)
 0.62A 2yvlB-5u2oA:
undetectable		 2yvlB-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 TYR A 384
ALA A 385
LEU A 388
ALA A 418
 None
 0.83A 3b6hA-5u2oA:
undetectable		 3b6hA-5u2oA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 TYR A 384
ALA A 385
LEU A 388
ALA A 418
 None
 0.88A 3b6hB-5u2oA:
undetectable		 3b6hB-5u2oA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 4 LEU A  86
PRO A  85
LEU A 536
ARG A 538
 None
 0.93A 3hcoB-5u2oA:
undetectable		 3hcoB-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 ASN A 354
GLY A 416
SER A 348
LEU A 421
PHE A 534
 None
 1.36A 3r24A-5u2oA:
undetectable		 3r24A-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ARG A 110
HIS A 111
LEU A  95
ASP A 103
 None
 1.42A 4cevA-5u2oA:
undetectable
4cevB-5u2oA:
undetectable		 4cevA-5u2oA:
undetectable
4cevB-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ASP A 103
ARG A 110
HIS A 111
LEU A  95
 None
 1.43A 4cevA-5u2oA:
undetectable
4cevC-5u2oA:
undetectable		 4cevA-5u2oA:
undetectable
4cevC-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ARG A 110
HIS A 111
LEU A  95
ASP A 103
 None
 1.43A 4cevD-5u2oA:
undetectable
4cevE-5u2oA:
undetectable		 4cevD-5u2oA:
undetectable
4cevE-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ARG A 110
HIS A 111
LEU A  95
ASP A 103
 None
 1.43A 4cevE-5u2oA:
undetectable
4cevF-5u2oA:
undetectable		 4cevE-5u2oA:
undetectable
4cevF-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ALA A  90
ALA A 530
PRO A 531
THR A 529
 None
 0.94A 4dtzB-5u2oA:
undetectable		 4dtzB-5u2oA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 7 ALA A  90
ALA A 530
PRO A 531
THR A 529
 None
 0.93A 4du2A-5u2oA:
undetectable		 4du2A-5u2oA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 7 ALA A 418
ALA A 441
ALA A 532
PRO A 531
 None
 0.95A 4du2A-5u2oA:
undetectable		 4du2A-5u2oA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5u2o J30 CCH
(Thermobacillus
composti) 		3 / 3 TYR A  63
ARG A  76
SER A  62
 None
 1.12A 4khpI-5u2oA:
undetectable
4khpJ-5u2oA:
undetectable		 4khpI-5u2oA:
18.94
4khpJ-5u2oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 10 ASP A 386
VAL A 389
SER A 393
ASN A 430
TYR A 433
 None
 1.01A 4ldoA-5u2oA:
undetectable		 4ldoA-5u2oA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 LEU A  95
VAL A 100
GLY A  99
CYH A 114
LEU A 184
 None
None
None
ZN  A 606 (-2.3A)
None
 1.32A 4ot2A-5u2oA:
undetectable		 4ot2A-5u2oA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 9 VAL A 400
LEU A 401
GLY A 416
ALA A 418
LEU A 421
 None
 0.99A 4rs0A-5u2oA:
undetectable		 4rs0A-5u2oA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 SER A  72
PRO A  74
ILE A  25
VAL A  65
VAL A  22
 None
 1.37A 4yfbI-5u2oA:
undetectable		 4yfbI-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 7 THR A 456
LEU A 481
THR A 476
THR A 107
LEU A 109
 None
 1.32A 4z91F-5u2oA:
2.0
4z91G-5u2oA:
2.1
4z91H-5u2oA:
2.0
4z91I-5u2oA:
1.9
4z91J-5u2oA:
1.8		 4z91F-5u2oA:
12.42
4z91G-5u2oA:
12.42
4z91H-5u2oA:
12.42
4z91I-5u2oA:
12.42
4z91J-5u2oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 7 ALA A 158
ARG A  91
GLY A 480
THR A 107
 None
 0.92A 5btdA-5u2oA:
undetectable
5btdC-5u2oA:
undetectable
5btdD-5u2oA:
undetectable		 5btdA-5u2oA:
10.81
5btdC-5u2oA:
10.81
5btdD-5u2oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 6 ALA A 158
ARG A  91
GLY A 480
THR A 107
 None
 0.91A 5btgA-5u2oA:
undetectable
5btgB-5u2oA:
undetectable
5btgC-5u2oA:
undetectable		 5btgA-5u2oA:
10.81
5btgB-5u2oA:
17.02
5btgC-5u2oA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 5 SER A 376
ARG A 324
GLY A 359
GLU A 321
 None
 1.13A 5btiA-5u2oA:
undetectable
5btiB-5u2oA:
undetectable		 5btiA-5u2oA:
10.81
5btiB-5u2oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 5 SER A 376
ARG A 324
GLY A 359
GLU A 321
 None
 1.21A 5btiC-5u2oA:
undetectable
5btiD-5u2oA:
undetectable		 5btiC-5u2oA:
10.81
5btiD-5u2oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 ASP A 144
ALA A 145
ASP A 147
TYR A 151
GLU A 523
 None
None
None
None
GOL  A 604 ( 4.8A)
 0.67A 5dgrA-5u2oA:
29.1		 5dgrA-5u2oA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 11 LEU A 438
LEU A 434
ARG A 431
MET A 168
LEU A 536
 None
 1.31A 5hyrB-5u2oA:
undetectable		 5hyrB-5u2oA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 VAL A 400
LEU A 401
GLY A 416
ALA A 418
LEU A 421
 None
 1.08A 5kirA-5u2oA:
undetectable		 5kirA-5u2oA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5u2o J30 CCH
(Thermobacillus
composti) 		5 / 12 GLY A 248
TYR A 284
ALA A 250
ASP A 214
LEU A 244
 None
 1.10A 6b3bA-5u2oA:
undetectable		 6b3bA-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5u2o J30 CCH
(Thermobacillus
composti) 		4 / 8 ASP A  53
LYS A   7
VAL A 389
ARG A 538
 None
 1.26A 6fbvD-5u2oA:
undetectable		 6fbvD-5u2oA:
undetectable