SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 1c9sA-5u2pA:
undetectable
1c9sK-5u2pA:
undetectable
1c9sA-5u2pA:
11.24
1c9sK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.33A 1c9sA-5u2pA:
undetectable
1c9sB-5u2pA:
undetectable
1c9sA-5u2pA:
11.24
1c9sB-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 1c9sB-5u2pA:
undetectable
1c9sC-5u2pA:
undetectable
1c9sB-5u2pA:
11.24
1c9sC-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.36A 1c9sF-5u2pA:
undetectable
1c9sG-5u2pA:
undetectable
1c9sF-5u2pA:
11.24
1c9sG-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.33A 1c9sJ-5u2pA:
undetectable
1c9sK-5u2pA:
undetectable
1c9sJ-5u2pA:
11.24
1c9sK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
4 / 6 LEU A  55
ARG A 331
TYR A 341
VAL A  44
None
1.13A 1db1A-5u2pA:
undetectable
1db1A-5u2pA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 1gtfA-5u2pA:
undetectable
1gtfB-5u2pA:
undetectable
1gtfA-5u2pA:
11.24
1gtfB-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 1gtfC-5u2pA:
undetectable
1gtfD-5u2pA:
undetectable
1gtfC-5u2pA:
11.24
1gtfD-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 1gtfE-5u2pA:
undetectable
1gtfF-5u2pA:
undetectable
1gtfE-5u2pA:
11.24
1gtfF-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 1gtfH-5u2pA:
undetectable
1gtfI-5u2pA:
undetectable
1gtfH-5u2pA:
11.24
1gtfI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 1gtfI-5u2pA:
undetectable
1gtfJ-5u2pA:
undetectable
1gtfI-5u2pA:
11.24
1gtfJ-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 1gtfO-5u2pA:
undetectable
1gtfP-5u2pA:
undetectable
1gtfO-5u2pA:
11.24
1gtfP-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 1gtfP-5u2pA:
undetectable
1gtfQ-5u2pA:
undetectable
1gtfP-5u2pA:
11.24
1gtfQ-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.32A 1gtfT-5u2pA:
undetectable
1gtfU-5u2pA:
undetectable
1gtfT-5u2pA:
11.24
1gtfU-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 11 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 1gtfU-5u2pA:
undetectable
1gtfV-5u2pA:
undetectable
1gtfU-5u2pA:
11.24
1gtfV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.33A 1gtfL-5u2pA:
undetectable
1gtfV-5u2pA:
undetectable
1gtfL-5u2pA:
11.24
1gtfV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.33A 1gtnG-5u2pA:
undetectable
1gtnH-5u2pA:
undetectable
1gtnG-5u2pA:
11.24
1gtnH-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.30A 1gtnL-5u2pA:
undetectable
1gtnM-5u2pA:
undetectable
1gtnL-5u2pA:
11.24
1gtnM-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 GLY A 310
ALA A 383
THR A 199
ALA A 144
ILE A 147
EDO  A 504 ( 3.9A)
EDO  A 504 (-2.8A)
EDO  A 504 ( 4.2A)
None
None
1.20A 1nt2A-5u2pA:
undetectable
1nt2A-5u2pA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 1utdA-5u2pA:
undetectable
1utdB-5u2pA:
undetectable
1utdA-5u2pA:
11.24
1utdB-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 1utdC-5u2pA:
undetectable
1utdD-5u2pA:
undetectable
1utdC-5u2pA:
11.24
1utdD-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.37A 1utdA-5u2pA:
undetectable
1utdK-5u2pA:
undetectable
1utdA-5u2pA:
11.24
1utdK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 1utdN-5u2pA:
undetectable
1utdO-5u2pA:
undetectable
1utdN-5u2pA:
11.24
1utdO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.36A 1utdQ-5u2pA:
undetectable
1utdR-5u2pA:
undetectable
1utdQ-5u2pA:
11.24
1utdR-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 1utdR-5u2pA:
undetectable
1utdS-5u2pA:
undetectable
1utdR-5u2pA:
11.24
1utdS-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 ILE A 384
ILE A 381
GLU A 211
ALA A 214
THR A 309
None
1.35A 2dtjA-5u2pA:
undetectable
2dtjB-5u2pA:
undetectable
2dtjA-5u2pA:
17.67
2dtjB-5u2pA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
3 / 3 SER A  52
TYR A  51
HIS A  50
None
0.59A 2r2vD-5u2pA:
undetectable
2r2vD-5u2pA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 11 ASN A 392
LEU A 217
ILE A 384
VAL A 237
LEU A 201
None
None
None
None
BR  A 501 ( 4.6A)
1.16A 3a51A-5u2pA:
undetectable
3a51A-5u2pA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 ALA A 221
LEU A 217
ILE A 384
ALA A 383
THR A 309
None
None
None
EDO  A 504 (-2.8A)
None
1.40A 3r9cA-5u2pA:
undetectable
3r9cA-5u2pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 LEU A 352
GLY A 310
CYH A 143
ILE A 127
LEU A 279
None
EDO  A 504 ( 3.9A)
None
None
None
1.03A 3uj6A-5u2pA:
undetectable
3uj6A-5u2pA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 LEU A 352
GLY A 310
CYH A 143
ILE A 127
LEU A 279
None
EDO  A 504 ( 3.9A)
None
None
None
1.05A 3uj7B-5u2pA:
undetectable
3uj7B-5u2pA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
4 / 6 PHE A 113
ALA A  93
PRO A  94
LEU A  84
None
0.95A 4dtzB-5u2pA:
undetectable
4dtzB-5u2pA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 LEU A  84
VAL A  99
ARG A  87
ALA A 318
ALA A  93
None
1.21A 4fiaA-5u2pA:
undetectable
4fiaA-5u2pA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 LEU A  84
VAL A  99
ARG A  87
ALA A 318
ALA A  93
None
1.21A 4fiaA-5u2pA:
undetectable
4fiaA-5u2pA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 HIS A 278
LEU A 308
ASP A 385
THR A 309
THR A 193
None
None
EDO  A 504 (-2.3A)
None
None
1.44A 4mubA-5u2pA:
undetectable
4mubA-5u2pA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
4 / 8 LEU A 238
VAL A 407
TRP A 228
LEU A 418
None
0.81A 4q0bA-5u2pA:
undetectable
4q0bA-5u2pA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eeuD-5u2pA:
undetectable
5eeuE-5u2pA:
undetectable
5eeuD-5u2pA:
11.24
5eeuE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eeuH-5u2pA:
undetectable
5eeuI-5u2pA:
undetectable
5eeuH-5u2pA:
11.24
5eeuI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eeuJ-5u2pA:
undetectable
5eeuK-5u2pA:
undetectable
5eeuJ-5u2pA:
11.24
5eeuK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eeuN-5u2pA:
undetectable
5eeuO-5u2pA:
undetectable
5eeuN-5u2pA:
11.24
5eeuO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eeuU-5u2pA:
undetectable
5eeuV-5u2pA:
undetectable
5eeuU-5u2pA:
11.24
5eeuV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eevD-5u2pA:
undetectable
5eevE-5u2pA:
undetectable
5eevD-5u2pA:
11.24
5eevE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eevH-5u2pA:
undetectable
5eevI-5u2pA:
undetectable
5eevH-5u2pA:
11.24
5eevI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eevJ-5u2pA:
undetectable
5eevK-5u2pA:
undetectable
5eevJ-5u2pA:
11.24
5eevK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eevN-5u2pA:
undetectable
5eevO-5u2pA:
undetectable
5eevN-5u2pA:
11.24
5eevO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eevU-5u2pA:
undetectable
5eevV-5u2pA:
undetectable
5eevU-5u2pA:
11.24
5eevV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eewD-5u2pA:
undetectable
5eewE-5u2pA:
undetectable
5eewD-5u2pA:
11.24
5eewE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eewH-5u2pA:
undetectable
5eewI-5u2pA:
undetectable
5eewH-5u2pA:
11.24
5eewI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eewJ-5u2pA:
undetectable
5eewK-5u2pA:
undetectable
5eewJ-5u2pA:
11.24
5eewK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eewN-5u2pA:
undetectable
5eewO-5u2pA:
undetectable
5eewN-5u2pA:
11.24
5eewO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eewU-5u2pA:
undetectable
5eewV-5u2pA:
undetectable
5eewU-5u2pA:
11.24
5eewV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eexD-5u2pA:
undetectable
5eexE-5u2pA:
undetectable
5eexD-5u2pA:
11.24
5eexE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eexH-5u2pA:
undetectable
5eexI-5u2pA:
undetectable
5eexH-5u2pA:
11.24
5eexI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eexJ-5u2pA:
undetectable
5eexK-5u2pA:
undetectable
5eexJ-5u2pA:
11.24
5eexK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eexN-5u2pA:
undetectable
5eexO-5u2pA:
undetectable
5eexN-5u2pA:
11.24
5eexO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eexQ-5u2pA:
undetectable
5eexR-5u2pA:
undetectable
5eexQ-5u2pA:
11.24
5eexR-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eexU-5u2pA:
undetectable
5eexV-5u2pA:
undetectable
5eexU-5u2pA:
11.24
5eexV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eeyD-5u2pA:
undetectable
5eeyE-5u2pA:
undetectable
5eeyD-5u2pA:
11.24
5eeyE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eeyH-5u2pA:
undetectable
5eeyI-5u2pA:
undetectable
5eeyH-5u2pA:
11.24
5eeyI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eeyJ-5u2pA:
undetectable
5eeyK-5u2pA:
undetectable
5eeyJ-5u2pA:
11.24
5eeyK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eeyN-5u2pA:
undetectable
5eeyO-5u2pA:
undetectable
5eeyN-5u2pA:
11.24
5eeyO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5eeyQ-5u2pA:
undetectable
5eeyR-5u2pA:
undetectable
5eeyQ-5u2pA:
11.24
5eeyR-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eeyU-5u2pA:
undetectable
5eeyV-5u2pA:
undetectable
5eeyU-5u2pA:
11.24
5eeyV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5eezD-5u2pA:
undetectable
5eezE-5u2pA:
undetectable
5eezD-5u2pA:
11.24
5eezE-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5eezH-5u2pA:
undetectable
5eezI-5u2pA:
undetectable
5eezH-5u2pA:
11.24
5eezI-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5eezJ-5u2pA:
undetectable
5eezK-5u2pA:
undetectable
5eezJ-5u2pA:
11.24
5eezK-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5eezN-5u2pA:
undetectable
5eezO-5u2pA:
undetectable
5eezN-5u2pA:
11.24
5eezO-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5eezQ-5u2pA:
undetectable
5eezR-5u2pA:
undetectable
5eezQ-5u2pA:
11.24
5eezR-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5eezU-5u2pA:
undetectable
5eezV-5u2pA:
undetectable
5eezU-5u2pA:
11.24
5eezV-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5ef0D-5u2pA:
undetectable
5ef0E-5u2pA:
undetectable
5ef0D-5u2pA:
11.24
5ef0E-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5ef0H-5u2pA:
undetectable
5ef0I-5u2pA:
undetectable
5ef0H-5u2pA:
11.24
5ef0I-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5ef0J-5u2pA:
undetectable
5ef0K-5u2pA:
undetectable
5ef0J-5u2pA:
11.24
5ef0K-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5ef0N-5u2pA:
undetectable
5ef0O-5u2pA:
undetectable
5ef0N-5u2pA:
11.24
5ef0O-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5ef0Q-5u2pA:
undetectable
5ef0R-5u2pA:
undetectable
5ef0Q-5u2pA:
11.24
5ef0R-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5ef0U-5u2pA:
undetectable
5ef0V-5u2pA:
undetectable
5ef0U-5u2pA:
11.24
5ef0V-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.36A 5ef1D-5u2pA:
undetectable
5ef1E-5u2pA:
undetectable
5ef1D-5u2pA:
11.24
5ef1E-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5ef1H-5u2pA:
undetectable
5ef1I-5u2pA:
undetectable
5ef1H-5u2pA:
11.24
5ef1I-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5ef1J-5u2pA:
undetectable
5ef1K-5u2pA:
undetectable
5ef1J-5u2pA:
11.24
5ef1K-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5ef1N-5u2pA:
undetectable
5ef1O-5u2pA:
undetectable
5ef1N-5u2pA:
11.24
5ef1O-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5ef1Q-5u2pA:
undetectable
5ef1R-5u2pA:
undetectable
5ef1Q-5u2pA:
11.24
5ef1R-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5ef1U-5u2pA:
undetectable
5ef1V-5u2pA:
undetectable
5ef1U-5u2pA:
11.24
5ef1V-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5ef2D-5u2pA:
undetectable
5ef2E-5u2pA:
undetectable
5ef2D-5u2pA:
11.24
5ef2E-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5ef2H-5u2pA:
undetectable
5ef2I-5u2pA:
undetectable
5ef2H-5u2pA:
11.24
5ef2I-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5ef2J-5u2pA:
undetectable
5ef2K-5u2pA:
undetectable
5ef2J-5u2pA:
11.24
5ef2K-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5ef2N-5u2pA:
undetectable
5ef2O-5u2pA:
undetectable
5ef2N-5u2pA:
11.24
5ef2O-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5ef2Q-5u2pA:
undetectable
5ef2R-5u2pA:
undetectable
5ef2Q-5u2pA:
11.24
5ef2R-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5ef2U-5u2pA:
undetectable
5ef2V-5u2pA:
undetectable
5ef2U-5u2pA:
11.24
5ef2V-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.35A 5ef3D-5u2pA:
undetectable
5ef3E-5u2pA:
undetectable
5ef3D-5u2pA:
11.24
5ef3E-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.32A 5ef3H-5u2pA:
undetectable
5ef3I-5u2pA:
undetectable
5ef3H-5u2pA:
11.24
5ef3I-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
1.34A 5ef3J-5u2pA:
undetectable
5ef3K-5u2pA:
undetectable
5ef3J-5u2pA:
11.24
5ef3K-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.33A 5ef3N-5u2pA:
undetectable
5ef3O-5u2pA:
undetectable
5ef3N-5u2pA:
11.24
5ef3O-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.35A 5ef3Q-5u2pA:
undetectable
5ef3R-5u2pA:
undetectable
5ef3Q-5u2pA:
11.24
5ef3R-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
1.34A 5ef3U-5u2pA:
undetectable
5ef3V-5u2pA:
undetectable
5ef3U-5u2pA:
11.24
5ef3V-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 10 PRO A 299
LEU A 171
PHE A 157
SER A 174
GLU A 173
None
1.29A 5tixB-5u2pA:
undetectable
5tixB-5u2pA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 12 LEU A 317
LEU A 139
ALA A 138
LEU A 101
ILE A  46
None
1.00A 5toaA-5u2pA:
undetectable
5toaA-5u2pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum)
5 / 9 VAL A  40
GLY A  67
LEU A 333
ARG A 325
ASP A  95
None
1.49A 6c2mC-5u2pA:
undetectable
6c2mC-5u2pA:
9.33