SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 147
GLN A 143
GLU A  56
ILE A  55
 None
 1.11A 2fcnA-5u2uA:
undetectable
2fcnB-5u2uA:
undetectable		 2fcnA-5u2uA:
18.47
2fcnB-5u2uA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 117
ASN A  70
ILE A 126
PHE A 121
 None
 1.01A 2jn3A-5u2uA:
undetectable		 2jn3A-5u2uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  48
PRO A  49
THR A  42
PRO A  43
 None
 0.86A 2v32C-5u2uA:
undetectable
2v32D-5u2uA:
undetectable		 2v32C-5u2uA:
20.76
2v32D-5u2uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  60
ILE A  55
GLY A  58
PHE A 121
 None
 0.98A 2vctD-5u2uA:
undetectable		 2vctD-5u2uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		6 / 12 TYR A  62
LEU A 117
LEU A  36
VAL A  69
GLU A  56
PHE A 130
 None
 1.36A 2weyA-5u2uA:
undetectable		 2weyA-5u2uA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  14
ALA A  38
ALA A  18
ALA A  37
ILE A 111
 None
 0.93A 3fc6A-5u2uA:
undetectable		 3fc6A-5u2uA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 137
PHE A 130
ILE A  55
LEU A  51
ILE A 140
 None
 1.08A 4kjkA-5u2uA:
undetectable		 4kjkA-5u2uA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		5 / 11 HIS A  34
ILE A  86
THR A  87
SER A  89
LEU A  73
 None
 1.40A 5albH-5u2uA:
undetectable		 5albH-5u2uA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5u2u HEAT SHOCK PROTEIN
104
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 137
PHE A 130
ILE A  55
LEU A  51
ILE A 140
 None
 1.01A 7dfrA-5u2uA:
undetectable		 7dfrA-5u2uA:
20.79