SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 11 ALA A 980
LEU A 984
ARG A 987
LEU A 850
ALA A 896
 None
 1.17A 1h9zA-5u30A:
4.1		 1h9zA-5u30A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 LEU A 342
PHE A 339
ALA A 340
LEU A 270
 None
 0.88A 1ukbA-5u30A:
undetectable		 1ukbA-5u30A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 4 ILE A 579
ASP A 814
LEU A 622
ARG A 616
 None
C  B  91 ( 3.4A)
None
G  B   8 ( 4.8A)
 1.45A 2a7qA-5u30A:
undetectable		 2a7qA-5u30A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 HIS A 402
ASP A 196
THR A 195
TYR A 194
 None
 1.37A 2dysA-5u30A:
undetectable
2dysC-5u30A:
3.3		 2dysA-5u30A:
17.22
2dysC-5u30A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 7 HIS A 402
ASP A 196
THR A 195
TYR A 194
 None
 1.38A 2eilA-5u30A:
undetectable
2eilC-5u30A:
3.0		 2eilA-5u30A:
17.22
2eilC-5u30A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 HIS A 402
ASP A 196
THR A 195
TYR A 194
 None
 1.41A 2eimN-5u30A:
undetectable
2eimP-5u30A:
3.0		 2eimN-5u30A:
17.22
2eimP-5u30A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 TRP A 931
LEU A1108
ARG A 913
GLY A 955
 None
 1.10A 2hs2B-5u30A:
undetectable		 2hs2B-5u30A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 ASP A 736
THR A 685
PRO A 686
 None
 0.51A 2q64B-5u30A:
undetectable		 2q64B-5u30A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 TRP A 733
GLN A 644
TRP A 723
 None
None
C  B  47 ( 4.5A)
 0.81A 2vqyA-5u30A:
undetectable		 2vqyA-5u30A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 ARG A  50
ARG A  51
PRO A  53
 None
 0.91A 2wljA-5u30A:
3.5		 2wljA-5u30A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 1.15A 3ag1J-5u30A:
undetectable		 3ag1J-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 11 ASP A 465
GLY A 467
ALA A 468
LEU A 888
VAL A 508
 None
 0.91A 3em4A-5u30A:
undetectable		 3em4A-5u30A:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 LYS A  69
LEU A  72
GLN A  97
LEU A  95
 None
 1.10A 3h5gB-5u30A:
undetectable
3h5gC-5u30A:
undetectable		 3h5gB-5u30A:
3.07
3h5gC-5u30A:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 GLU A 958
HIS A 975
THR A 575
 None
A  B  10 ( 4.5A)
None
 0.89A 3hkuA-5u30A:
undetectable		 3hkuA-5u30A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 7 GLN A 996
ARG A1079
PHE A 901
PRO A 908
 None
 1.30A 3ql6A-5u30A:
undetectable		 3ql6A-5u30A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 GLY A 906
ASP A 902
ARG A 904
GLN A 985
 None
None
A  B   5 ( 3.1A)
None
 1.06A 3qx3B-5u30A:
undetectable		 3qx3B-5u30A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 ASP A 736
THR A 685
PRO A 686
 None
 0.54A 3tkgD-5u30A:
undetectable		 3tkgD-5u30A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 10 LEU A 889
ARG A 515
LEU A 560
GLU A 517
VAL A 525
 None
 1.38A 3ua5B-5u30A:
0.0		 3ua5B-5u30A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 4 ASN A 532
PHE A 876
SER A 851
GLN A 877
 None
 1.37A 3v5vA-5u30A:
0.5		 3v5vA-5u30A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 TYR A 545
MET A 567
LEU A 888
 None
 1.01A 3vw1D-5u30A:
2.0		 3vw1D-5u30A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 9 ASP A1080
ALA A 907
ASP A 902
VAL A1100
ILE A1085
 None
 1.46A 3wsjA-5u30A:
undetectable		 3wsjA-5u30A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 4 VAL A 537
VAL A 525
ASN A 607
ILE A 604
 None
 1.21A 4cutA-5u30A:
3.6		 4cutA-5u30A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 LYS A 498
ARG A 498
TRP A  23
 None
 1.33A 4i90A-5u30A:
undetectable		 4i90A-5u30A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 LEU A 847
SER A 568
LEU A 844
LEU A 879
 None
 1.23A 4n09B-5u30A:
undetectable		 4n09B-5u30A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 LEU A 847
SER A 568
LEU A 844
LEU A 879
 None
 1.22A 4n09D-5u30A:
undetectable		 4n09D-5u30A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 12 LEU A 350
SER A 299
VAL A 264
ALA A 295
LEU A 368
 None
 1.29A 4nc3A-5u30A:
6.3		 4nc3A-5u30A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 ARG A 616
GLN A 618
GLU A 819
 G  B   8 ( 4.8A)
G  B   8 ( 3.5A)
G  B   8 ( 3.3A)
 0.75A 4tvtA-5u30A:
undetectable		 4tvtA-5u30A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 ARG A1103
GLN A1102
GLU A 968
 None
 0.91A 4tvtA-5u30A:
undetectable		 4tvtA-5u30A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		5 / 12 HIS A 939
GLU A 938
PHE A 935
GLY A 955
PRO A 953
 None
 1.41A 4uinH-5u30A:
undetectable
4uinL-5u30A:
undetectable		 4uinH-5u30A:
11.34
4uinL-5u30A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 LYS A 188
ARG A 192
VAL A 193
 None
SO4  A1202 (-3.8A)
None
 1.01A 4x3uA-5u30A:
undetectable
4x3uB-5u30A:
undetectable		 4x3uA-5u30A:
6.84
4x3uB-5u30A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		6 / 12 VAL A 434
LEU A 423
ARG A 432
GLY A  21
VAL A 500
LEU A  12
 None
 1.40A 4y8wA-5u30A:
undetectable		 4y8wA-5u30A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		6 / 12 VAL A 434
LEU A 423
ARG A 432
GLY A  21
VAL A 500
LEU A  12
 None
 1.47A 4y8wB-5u30A:
undetectable		 4y8wB-5u30A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 7 LEU A 502
GLY A 478
GLY A 477
ILE A 459
 None
 0.59A 4yjiA-5u30A:
undetectable		 4yjiA-5u30A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 PHE A 472
LEU A 560
GLY A 556
ASP A 465
 None
 0.89A 5ik1A-5u30A:
undetectable		 5ik1A-5u30A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 GLU A 956
GLY A 957
ARG A 574
ARG A 900
 None
 1.38A 5jcnB-5u30A:
undetectable		 5jcnB-5u30A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 8 SER A1082
THR A 905
ARG A1103
ILE A1085
 None
 1.02A 5jhdE-5u30A:
undetectable
5jhdG-5u30A:
undetectable		 5jhdE-5u30A:
12.08
5jhdG-5u30A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 1.10A 5x19J-5u30A:
undetectable		 5x19J-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 1.15A 5x1bJ-5u30A:
undetectable		 5x1bJ-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 1.24A 5x1bW-5u30A:
undetectable		 5x1bW-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 TYR A 716
VAL A 719
LEU A 655
SER A 660
 None
 1.25A 6a7pA-5u30A:
3.5		 6a7pA-5u30A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		3 / 3 HIS A 490
HIS A 492
ARG A 494
 G  B  52 ( 3.8A)
G  B  53 ( 3.5A)
G  B  53 ( 3.6A)
 0.75A 6b58A-5u30A:
3.2		 6b58A-5u30A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 6 MET A 567
GLY A 891
ALA A 883
LEU A 888
 None
 0.97A 6fosA-5u30A:
undetectable		 6fosA-5u30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 7 HIS A 262
ARG A 360
ASP A 354
GLU A1072
 None
 1.40A 6mn4F-5u30A:
undetectable		 6mn4F-5u30A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 1.21A 6nknJ-5u30A:
undetectable		 6nknJ-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 5 ARG A 534
MET A 893
THR A 892
LEU A 846
 None
 0.93A 6nknW-5u30A:
undetectable		 6nknW-5u30A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1
(Alicyclobacillus
acidoterrestris) 		4 / 7 HIS A 402
ASP A 196
THR A 195
TYR A 194
 None
 1.35A 6nmpN-5u30A:
undetectable
6nmpP-5u30A:
5.4		 6nmpN-5u30A:
17.22
6nmpP-5u30A:
11.66