SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A  81
HIS A 237
VAL A 100
SER A  20
 None
ZN  A 501 ( 3.2A)
None
None
 1.12A 1kb9A-5u39A:
undetectable
1kb9C-5u39A:
undetectable
1kb9D-5u39A:
undetectable
1kb9E-5u39A:
undetectable		 1kb9A-5u39A:
20.19
1kb9C-5u39A:
22.08
1kb9D-5u39A:
22.29
1kb9E-5u39A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 0.98A 1kglA-5u39A:
undetectable		 1kglA-5u39A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 192
VAL A 216
GLU A 233
ILE A 197
HIS A  78
 C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
ZN  A 501 ( 3.3A)
 1.17A 1vhwA-5u39A:
undetectable
1vhwD-5u39A:
undetectable		 1vhwA-5u39A:
21.45
1vhwD-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 192
VAL A 216
GLU A 233
ILE A 197
HIS A  78
 C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
ZN  A 501 ( 3.3A)
 1.17A 1vhwC-5u39A:
undetectable
1vhwE-5u39A:
undetectable		 1vhwC-5u39A:
21.45
1vhwE-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  78
GLY A 192
VAL A 216
GLU A 233
ILE A 197
 ZN  A 501 ( 3.3A)
C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
 1.17A 1vhwA-5u39A:
undetectable
1vhwD-5u39A:
undetectable		 1vhwA-5u39A:
21.45
1vhwD-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  78
GLY A 192
VAL A 216
GLU A 233
ILE A 197
 ZN  A 501 ( 3.3A)
C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
 1.17A 1vhwC-5u39A:
undetectable
1vhwE-5u39A:
undetectable		 1vhwC-5u39A:
21.45
1vhwE-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  79
PHE A  39
LEU A  26
SER A  20
 None
 0.89A 1wrlE-5u39A:
undetectable
1wrlF-5u39A:
undetectable		 1wrlE-5u39A:
15.12
1wrlF-5u39A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 240
ASP A 241
GLY A 192
ALA A 188
 None
ZN  A 501 ( 2.0A)
C90  A 502 ( 4.5A)
None
 0.90A 2aohA-5u39A:
undetectable		 2aohA-5u39A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  18
GLY A 208
LEU A 207
LEU A 200
ARG A 201
 None
None
None
None
C90  A 502 (-3.3A)
 1.07A 2f8dA-5u39A:
undetectable		 2f8dA-5u39A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  18
GLY A 208
LEU A 207
LEU A 200
ARG A 201
 None
None
None
None
C90  A 502 (-3.3A)
 1.08A 2f8dB-5u39A:
undetectable		 2f8dB-5u39A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 181
VAL A 111
ILE A 102
HIS A 237
LEU A 240
 None
None
None
ZN  A 501 ( 3.2A)
None
 1.28A 2ft9A-5u39A:
undetectable		 2ft9A-5u39A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  66
LEU A  26
VAL A  93
LEU A 248
ILE A  37
 None
 1.22A 2uxoB-5u39A:
undetectable		 2uxoB-5u39A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 MET A  83
GLY A  85
GLN A 115
PHE A 112
GLY A 108
 None
 1.35A 2zxwA-5u39A:
undetectable
2zxwB-5u39A:
undetectable
2zxwT-5u39A:
undetectable		 2zxwA-5u39A:
18.96
2zxwB-5u39A:
22.26
2zxwT-5u39A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 227
ASN A 224
VAL A 164
ILE A 215
 None
 0.65A 3a2qA-5u39A:
undetectable		 3a2qA-5u39A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 MET A  83
GLY A  85
GLN A 115
PHE A 112
GLY A 108
 None
 1.35A 3asnA-5u39A:
undetectable
3asnB-5u39A:
undetectable
3asnT-5u39A:
undetectable		 3asnA-5u39A:
18.96
3asnB-5u39A:
22.26
3asnT-5u39A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 145
GLN A 269
PHE A 260
ARG A 272
 None
 1.09A 3bjwH-5u39A:
undetectable		 3bjwH-5u39A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 145
GLN A 269
PHE A 260
ARG A 272
 None
 1.17A 3bjwF-5u39A:
undetectable		 3bjwF-5u39A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 172
SER A 173
VAL A 174
ILE A 243
HIS A 237
 None
None
None
None
ZN  A 501 ( 3.2A)
 1.07A 4c49A-5u39A:
undetectable		 4c49A-5u39A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  99
ARG A 201
GLY A 208
GLY A  17
 None
C90  A 502 (-3.3A)
None
None
 0.84A 4rdxA-5u39A:
undetectable		 4rdxA-5u39A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  86
ALA A 117
GLY A 108
ALA A 107
SER A 186
LEU A 240
 None
 1.29A 5kirA-5u39A:
undetectable		 5kirA-5u39A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A  75
HIS A  78
ASP A 241
HIS A 237
 None
ZN  A 501 ( 3.3A)
ZN  A 501 ( 2.0A)
ZN  A 501 ( 3.2A)
 1.49A 6dchA-5u39A:
undetectable		 6dchA-5u39A:
21.14