SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 5 ARG A  78
LYS A 313
ALA A 311
GLY A 525
 None
 1.14A 1e7cA-5u3cA:
undetectable		 1e7cA-5u3cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A 341
VAL A 333
VAL A 384
ASP A 388
ILE A 362
 None
 1.37A 1gebA-5u3cA:
undetectable		 1gebA-5u3cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 251
PRO A 248
LEU A 250
ARG A 211
 None
None
None
ADP  A 602 (-3.4A)
 1.44A 1hrkB-5u3cA:
3.0		 1hrkB-5u3cA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 10 PHE A 518
GLY A 442
GLU A  59
LEU A  71
PRO A  49
 None
 1.49A 1mjqG-5u3cA:
undetectable
1mjqH-5u3cA:
undetectable		 1mjqG-5u3cA:
11.84
1mjqH-5u3cA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A  19
ALA A  22
ILE A   6
ILE A 141
ILE A  38
 ADP  A 602 ( 4.8A)
None
None
None
None
 0.95A 1n49B-5u3cA:
undetectable		 1n49B-5u3cA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A  19
ALA A  22
ILE A   6
ILE A 141
ILE A  38
 ADP  A 602 ( 4.8A)
None
None
None
None
 0.94A 1n49C-5u3cA:
undetectable		 1n49C-5u3cA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A  19
GLY A  17
ILE A   6
LEU A  25
ALA A  23
 ADP  A 602 ( 4.8A)
ADP  A 602 (-3.2A)
None
None
None
 1.01A 1x7pA-5u3cA:
3.0
1x7pB-5u3cA:
undetectable		 1x7pA-5u3cA:
19.96
1x7pB-5u3cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 317
HIS A 314
LYS A 313
 None
 1.07A 1y7iA-5u3cA:
3.6		 1y7iA-5u3cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 211
ASP A  72
ASP A  42
 ADP  A 602 (-3.4A)
ADP  A 602 (-3.8A)
None
 0.83A 2ejtA-5u3cA:
undetectable		 2ejtA-5u3cA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A 532
PRO A 350
VAL A 308
LEU A 327
ILE A 325
 None
 1.36A 2fj1A-5u3cA:
undetectable		 2fj1A-5u3cA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 251
PRO A 248
LEU A 250
ARG A 211
 None
None
None
ADP  A 602 (-3.4A)
 1.40A 2hrcB-5u3cA:
3.4		 2hrcB-5u3cA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  19
ALA A  22
ILE A   6
ILE A 141
ILE A  38
 ADP  A 602 ( 4.8A)
None
None
None
None
 1.01A 2pynB-5u3cA:
undetectable		 2pynB-5u3cA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 350
GLY A 296
TYR A 305
 None
 0.64A 2vouB-5u3cA:
undetectable		 2vouB-5u3cA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 350
GLY A 296
TYR A 305
 None
 0.64A 2vouC-5u3cA:
undetectable		 2vouC-5u3cA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 PRO A 350
GLY A 351
GLY A 352
ILE A 501
ALA A 385
 None
 0.97A 3douA-5u3cA:
undetectable		 3douA-5u3cA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 9 PHE A 529
VAL A 533
GLY A 531
ASN A 319
GLY A 316
 None
 1.40A 3kmoA-5u3cA:
undetectable		 3kmoA-5u3cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 142
VAL A 139
ALA A  22
ALA A  21
LEU A 174
 None
 1.21A 3mteA-5u3cA:
undetectable		 3mteA-5u3cA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 ARG A 468
ALA A 304
ILE A  55
PRO A 350
GLU A 517
 None
 1.22A 3qelA-5u3cA:
4.4
3qelB-5u3cA:
3.6		 3qelA-5u3cA:
22.32
3qelB-5u3cA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 6 THR A 120
ILE A 123
THR A   9
PHE A   7
 None
 1.08A 4acbC-5u3cA:
7.7		 4acbC-5u3cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 351
GLY A 352
LEU A 380
HIS A 469
HIS A 515
 None
 0.65A 4l8fB-5u3cA:
18.6		 4l8fB-5u3cA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 351
GLY A 352
LEU A 380
HIS A 469
HIS A 515
 None
 0.69A 4l8fD-5u3cA:
18.5		 4l8fD-5u3cA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 463
GLY A 490
VAL A 498
HIS A 467
 None
 1.03A 4oltA-5u3cA:
undetectable		 4oltA-5u3cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 463
GLY A 490
VAL A 498
HIS A 467
 None
 1.05A 4oltB-5u3cA:
undetectable		 4oltB-5u3cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  29
GLY A  33
LEU A 266
THR A  82
ILE A  80
 None
 1.34A 4p6xA-5u3cA:
undetectable		 4p6xA-5u3cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 MET A  52
ASP A  70
PHE A  61
 None
 1.02A 4xeyA-5u3cA:
undetectable		 4xeyA-5u3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 MET A  52
ASP A  70
PHE A  61
 None
 0.98A 4xeyB-5u3cA:
undetectable		 4xeyB-5u3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 11 ARG A 468
ALA A 304
ILE A  55
PRO A 350
GLU A 517
 None
 1.23A 5ewjA-5u3cA:
4.3
5ewjB-5u3cA:
2.1		 5ewjA-5u3cA:
22.60
5ewjB-5u3cA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 ARG A 468
ALA A 304
ILE A  55
PRO A 350
GLU A 517
 None
 1.24A 5ewjC-5u3cA:
3.9
5ewjD-5u3cA:
3.4		 5ewjC-5u3cA:
22.60
5ewjD-5u3cA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		3 / 3 ILE A 373
PRO A 374
ILE A 347
 None
 0.40A 5hw8F-5u3cA:
undetectable		 5hw8F-5u3cA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A 241
ASP A 240
PHE A  79
ARG A 211
GLY A  17
 ADP  A 602 (-3.9A)
ADP  A 602 (-3.9A)
None
ADP  A 602 (-3.4A)
ADP  A 602 (-3.2A)
 1.16A 5m54E-5u3cA:
4.0		 5m54E-5u3cA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 4 VAL A 137
LEU A 128
ASN A  35
ASP A 135
 None
 1.38A 5vcyA-5u3cA:
undetectable		 5vcyA-5u3cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 6 GLU A 517
LYS A 306
GLU A 310
ALA A 311
 None
 1.11A 6an0A-5u3cA:
undetectable		 6an0A-5u3cA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 4 ARG A  81
GLU A  30
GLU A 275
ARG A 523
 None
 1.29A 6fk2A-5u3cA:
undetectable		 6fk2A-5u3cA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5u3c CTP SYNTHASE
(Escherichia
coli) 		4 / 4 ARG A 523
GLU A 275
GLU A  30
ARG A  81
 None
 1.31A 6fk2A-5u3cA:
undetectable		 6fk2A-5u3cA:
14.90