SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 TYR A 144
ARG A 146
GLY A 313
THR A 314
ALA A 315
 7TS  A 400 (-4.6A)
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.33A 2a1hA-5u3fA:
39.5
2a1hB-5u3fA:
39.5		 2a1hA-5u3fA:
37.43
2a1hB-5u3fA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 10 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
 7TS  A 400 (-4.6A)
None
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.32A 2coiA-5u3fA:
39.9
2coiB-5u3fA:
40.0		 2coiA-5u3fA:
36.57
2coiB-5u3fA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 10 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
 7TS  A 400 (-4.6A)
None
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.37A 2coiA-5u3fA:
39.9
2coiB-5u3fA:
40.0		 2coiA-5u3fA:
36.57
2coiB-5u3fA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		7 / 11 PHE A  77
TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
 None
7TS  A 400 (-4.6A)
None
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.32A 2cojA-5u3fA:
39.9
2cojB-5u3fA:
40.0		 2cojA-5u3fA:
36.57
2cojB-5u3fA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 9 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
 7TS  A 400 (-4.6A)
None
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.27A 2cojA-5u3fA:
39.9
2cojB-5u3fA:
40.0		 2cojA-5u3fA:
36.57
2cojB-5u3fA:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 8 TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
 7TS  A 400 (-4.6A)
None
7TS  A 400 (-3.4A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.49A 2ej3A-5u3fA:
33.6		 2ej3A-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 144
THR A 314
ALA A 315
ALA A 316
 7TS  A 400 (-4.6A)
7TS  A 400 (-3.6A)
None
None
 0.56A 2ej3A-5u3fA:
33.6		 2ej3A-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		8 / 10 PHE A  77
TYR A 144
ARG A 146
TYR A 209
GLY A 243
GLY A 313
THR A 314
ALA A 315
 None
7TS  A 400 (-4.6A)
None
7TS  A 400 (-4.3A)
7TS  A 400 (-3.4A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
 0.41A 2ej3B-5u3fA:
33.3		 2ej3B-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		8 / 10 PHE A  77
TYR A 144
ARG A 146
TYR A 209
GLY A 313
THR A 314
ALA A 315
ALA A 316
 None
7TS  A 400 (-4.6A)
None
7TS  A 400 (-4.3A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
None
 0.68A 2ej3B-5u3fA:
33.3		 2ej3B-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 101
TYR A 209
ARG A 194
GLU A 240
 7TS  A 400 (-2.7A)
7TS  A 400 (-4.3A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.3A)
 1.02A 2zt7A-5u3fA:
undetectable		 2zt7A-5u3fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 305
ILE A 306
PHE A 248
ALA A 303
ILE A 333
 None
 1.06A 3ndiA-5u3fA:
undetectable		 3ndiA-5u3fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 7TS  A 400 (-3.1A)
None
7TS  A 400 (-3.4A)
None
None
 1.03A 3sudA-5u3fA:
undetectable		 3sudA-5u3fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 7TS  A 400 (-3.1A)
None
7TS  A 400 (-3.4A)
None
None
 1.10A 3sueB-5u3fA:
undetectable		 3sueB-5u3fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 170
ARG A 124
GLU A 121
LEU A 167
VAL A  40
 None
 1.28A 4azsA-5u3fA:
undetectable		 4azsA-5u3fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 296
ALA A 311
LEU A 258
THR A 342
ILE A 318
 None
 1.13A 4hytA-5u3fA:
undetectable		 4hytA-5u3fA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 296
ALA A 311
LEU A 258
THR A 342
ILE A 318
 None
 1.15A 4hytC-5u3fA:
undetectable		 4hytC-5u3fA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 146
GLU A  78
PHE A 119
 None
 0.78A 4kszA-5u3fA:
undetectable		 4kszA-5u3fA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 311
VAL A 309
GLY A 339
THR A 342
 None
 1.00A 4ubeA-5u3fA:
undetectable		 4ubeA-5u3fA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 367
LEU A 143
ALA A  82
LEU A  80
ALA A 170
 None
 1.24A 4x1kA-5u3fA:
undetectable
4x1kB-5u3fA:
undetectable		 4x1kA-5u3fA:
21.00
4x1kB-5u3fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 246
LEU A 230
GLU A 296
ALA A 302
GLY A 304
 None
 1.13A 5uxdB-5u3fA:
undetectable		 5uxdB-5u3fA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 125
VAL A 118
ARG A  54
ILE A  42
ASP A  43
 None
 1.46A 6bxnA-5u3fA:
undetectable		 6bxnA-5u3fA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 7TS  A 400 (-3.1A)
None
7TS  A 400 (-3.4A)
None
None
 1.08A 6c2mD-5u3fA:
undetectable		 6c2mD-5u3fA:
11.75