SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 ALA H  61
VAL H  48
TRP H  47
 None
 0.92A 1jo3A-5u3lH:
undetectable		 1jo3A-5u3lH:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 ALA H  61
VAL H  48
TRP H  47
 None
 0.92A 1jo3B-5u3lH:
undetectable		 1jo3B-5u3lH:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.27A 4em2A-5u3lH:
undetectable		 4em2A-5u3lH:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 TYR H  59
ARG H  82
HIS H  81
 None
 1.05A 4fubA-5u3lH:
undetectable		 4fubA-5u3lH:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 THR H  82
GLY H  16
VAL H  12
PRO H  14
 None
 1.03A 4grkA-5u3lH:
undetectable		 4grkA-5u3lH:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 5u3l DH511.2 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 TYR H 145
THR H 151
CYH H 140
THR H 165
 None
 1.47A 6cnkA-5u3lH:
undetectable
6cnkB-5u3lH:
undetectable		 6cnkA-5u3lH:
14.43
6cnkB-5u3lH:
14.43