SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		7 / 12 TYR L  36
GLN L  89
LEU L  96
PHE L  98
TRP H  33
VAL H  37
TRP H 103
 None
 0.96A 1h8sA-5u3pL:
15.7		 1h8sA-5u3pL:
38.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5u3p DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.69A 1ictD-5u3pL:
undetectable		 1ictD-5u3pL:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 TRP H  33
TYR H 100
LEU L  96
 None
 0.92A 1kxhA-5u3pH:
undetectable		 1kxhA-5u3pH:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5u3p DH511.4 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 VAL H  23
GLY H  24
VAL H   5
TRP H 103
 None
 1.31A 1tkqB-5u3pH:
undetectable		 1tkqB-5u3pH:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5u3p DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-5u3pL:
undetectable		 2aojA-5u3pL:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.49A 2oldA-5u3pH:
11.6
2oldB-5u3pH:
17.1		 2oldA-5u3pH:
32.20
2oldB-5u3pH:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.42A 2oldA-5u3pL:
21.5
2oldB-5u3pL:
20.1		 2oldA-5u3pL:
41.07
2oldB-5u3pL:
41.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u3p DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.33A 2ombC-5u3pL:
20.9
2ombD-5u3pL:
19.8		 2ombC-5u3pL:
41.07
2ombD-5u3pL:
41.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.73A 2ombC-5u3pL:
20.9
2ombD-5u3pL:
19.8		 2ombC-5u3pL:
41.07
2ombD-5u3pL:
41.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 PHE L  98
GLY L  99
GLY H  60
MET H 100
 None
 0.71A 2y6rB-5u3pL:
undetectable		 2y6rB-5u3pL:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u3p DH511.4 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H 110
GLU H 148
HIS H 200
 None
 0.70A 3g1uB-5u3pH:
undetectable		 3g1uB-5u3pH:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5u3p DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 TYR L  36
GLN L  89
LEU L  96
PHE L  98
 None
 0.87A 3ls4L-5u3pL:
20.5		 3ls4L-5u3pL:
56.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 PHE L  98
GLY L  99
GLY H  60
MET H 100
 None
 0.73A 3v3nB-5u3pL:
undetectable		 3v3nB-5u3pL:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 PHE L  98
GLY L  99
GLY H  60
MET H 100
 None
 0.74A 3v3nC-5u3pL:
undetectable		 3v3nC-5u3pL:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5u3p DH511.4 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.16A 4em2A-5u3pH:
undetectable		 4em2A-5u3pH:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.30A 4qztA-5u3pL:
undetectable		 4qztA-5u3pL:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5u3p DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 VAL L  19
ILE L  21
VAL L 104
THR L 102
 None
 0.74A 4xdtA-5u3pL:
undetectable		 4xdtA-5u3pL:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 PHE L 118
LEU L 135
SER H 132
VAL L 196
HIS L 198
 None
 1.38A 5h1eA-5u3pL:
undetectable		 5h1eA-5u3pL:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 VAL H   2
PRO L  95
PHE H  27
GLN L  89
ILE H  69
 None
 1.32A 6becA-5u3pH:
undetectable
6becB-5u3pH:
2.1
6becC-5u3pH:
2.2		 6becA-5u3pH:
15.57
6becB-5u3pH:
15.57
6becC-5u3pH:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5u3p DH511.4 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 PRO H 185
SER H 187
SER H 188
 None
 0.65A 6bpyA-5u3pH:
undetectable		 6bpyA-5u3pH:
21.39