SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		4 / 6 VAL A 194
GLY A 195
LEU A 212
GLU A 265
 None
 0.99A 1fduD-5u4nA:
undetectable		 1fduD-5u4nA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		4 / 4 SER A 107
PHE A 181
GLU A 142
GLY A 141
 None
 1.42A 1icvA-5u4nA:
undetectable
1icvB-5u4nA:
undetectable		 1icvA-5u4nA:
20.11
1icvB-5u4nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
 None
None
None
None
PO4  A 401 ( 3.2A)
 1.14A 1igxA-5u4nA:
0.3		 1igxA-5u4nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		4 / 6 ASP A 111
GLY A 112
THR A 114
PRO A 115
 None
 0.70A 1n4fA-5u4nA:
undetectable		 1n4fA-5u4nA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 10 ALA A 124
THR A 125
VAL A 128
HIS A  81
ALA A  86
 None
 1.24A 1r55A-5u4nA:
undetectable		 1r55A-5u4nA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 8 LEU A  10
ASN A 275
GLU A 140
HIS A 232
ALA A 189
 None
PO4  A 402 ( 4.0A)
None
PO4  A 402 (-3.6A)
None
 1.02A 2bnnA-5u4nA:
undetectable
2bnnB-5u4nA:
undetectable		 2bnnA-5u4nA:
20.49
2bnnB-5u4nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		4 / 7 SER A 174
ASP A 177
SER A 107
LEU A 190
 None
 1.03A 2cdqB-5u4nA:
undetectable		 2cdqB-5u4nA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 HIS A  84
SER A 116
GLY A 144
ILE A 143
VAL A 187
 PO4  A 402 (-3.6A)
None
None
None
None
 1.21A 2uxpB-5u4nA:
undetectable		 2uxpB-5u4nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.99A 2yjaB-5u4nA:
undetectable		 2yjaB-5u4nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.05A 3olsA-5u4nA:
undetectable		 3olsA-5u4nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.05A 3q95A-5u4nA:
undetectable		 3q95A-5u4nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.04A 3q95B-5u4nA:
undetectable		 3q95B-5u4nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.01A 3uudA-5u4nA:
undetectable		 3uudA-5u4nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		4 / 8 VAL A 128
CYH A 135
VAL A 139
ILE A  95
 None
 1.05A 4aftD-5u4nA:
undetectable
4aftE-5u4nA:
undetectable		 4aftD-5u4nA:
18.73
4aftE-5u4nA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
 None
None
None
None
PO4  A 401 ( 3.2A)
 0.94A 4e1gA-5u4nA:
undetectable		 4e1gA-5u4nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 203
GLY A 155
ALA A 154
SER A 197
GLY A 233
 None
None
None
None
PO4  A 401 ( 3.2A)
 0.99A 4e1gB-5u4nA:
0.8		 4e1gB-5u4nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.99A 4pxmA-5u4nA:
undetectable		 4pxmA-5u4nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.00A 4pxmB-5u4nA:
undetectable		 4pxmB-5u4nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 9 ARG A 290
LEU A 282
ILE A 245
SER A 284
ALA A 287
 EDO  A 404 (-3.1A)
None
None
None
None
 1.40A 4z69A-5u4nA:
undetectable		 4z69A-5u4nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 10 ARG A 290
LEU A 282
ILE A 245
SER A 284
ALA A 287
 EDO  A 404 (-3.1A)
None
None
None
None
 1.47A 4z69I-5u4nA:
undetectable		 4z69I-5u4nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 10 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.00A 5dx3A-5u4nA:
undetectable		 5dx3A-5u4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 10 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.94A 5dxbA-5u4nA:
undetectable		 5dxbA-5u4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.94A 5dxbB-5u4nA:
undetectable		 5dxbB-5u4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.00A 5dxgB-5u4nA:
undetectable		 5dxgB-5u4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.98A 5gtrA-5u4nA:
undetectable		 5gtrA-5u4nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 HIS A  84
THR A 196
ALA A  51
ILE A  46
MET A   6
 PO4  A 402 (-3.6A)
None
None
None
None
 1.24A 5iwuA-5u4nA:
undetectable		 5iwuA-5u4nA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 12 PHE A  99
LEU A  62
ASN A  24
ARG A 281
GLU A 157
 None
None
PO4  A 402 ( 4.7A)
None
PO4  A 402 (-3.6A)
 1.12A 5v1tA-5u4nA:
4.0		 5v1tA-5u4nA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 9 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 1.02A 5wgqA-5u4nA:
undetectable		 5wgqA-5u4nA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5u4n FRUCTOSE-1
(Neisseria
gonorrhoeae) 		5 / 11 VAL A 145
GLY A 144
SER A 107
LEU A 108
ASN A 121
 None
 1.25A 5x6yC-5u4nA:
undetectable		 5x6yC-5u4nA:
18.22