SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ILE A 308
PHE A 288
PHE A 295
PHE A 363
 None
 0.95A 1e71M-5u4oA:
undetectable		 1e71M-5u4oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ILE A 382
PHE A 288
PHE A 295
PHE A 363
 None
 0.94A 1e71M-5u4oA:
undetectable		 1e71M-5u4oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ILE A 308
PHE A 288
PHE A 295
PHE A 363
 None
 0.93A 1e72M-5u4oA:
undetectable		 1e72M-5u4oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ILE A 382
PHE A 288
PHE A 295
PHE A 363
 None
 0.94A 1e72M-5u4oA:
undetectable		 1e72M-5u4oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 SER A 384
VAL A 317
GLY A 312
ILE A 313
 None
 0.82A 1gtnC-5u4oA:
undetectable
1gtnD-5u4oA:
undetectable		 1gtnC-5u4oA:
13.65
1gtnD-5u4oA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 9 LEU A 515
ILE A 507
PHE A 505
ARG A  50
ILE A  48
 None
 1.18A 2f7aA-5u4oA:
2.4		 2f7aA-5u4oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 5 PHE A 434
PHE A 446
PHE A 415
VAL A 328
 None
 1.20A 2lh6A-5u4oA:
undetectable		 2lh6A-5u4oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 SER A 510
ARG A  82
TYR A 512
TYR A  72
 None
 1.38A 2vmyA-5u4oA:
undetectable
2vmyB-5u4oA:
undetectable		 2vmyA-5u4oA:
21.44
2vmyB-5u4oA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 10 THR A 330
GLY A 491
HIS A 494
PRO A 509
ILE A 492
 None
 1.42A 2y7pA-5u4oA:
4.3		 2y7pA-5u4oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 9 THR A 407
ALA A 406
LEU A 404
ALA A 402
ASN A 370
 None
 1.34A 3kp6B-5u4oA:
undetectable		 3kp6B-5u4oA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 11 GLU A 240
GLY A 246
ALA A 242
ILE A 248
ALA A 253
 None
 1.09A 3nmuB-5u4oA:
undetectable
3nmuJ-5u4oA:
undetectable		 3nmuB-5u4oA:
21.69
3nmuJ-5u4oA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 5 ILE A 173
MET A  86
ASN A  85
PHE A 174
 None
 1.25A 3octA-5u4oA:
undetectable		 3octA-5u4oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 11 ILE A 495
GLU A 265
ARG A 490
VAL A 264
LYS A 268
 None
 1.45A 3qwuB-5u4oA:
undetectable		 3qwuB-5u4oA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ALA A 422
SER A 176
THR A 423
SER A 172
 None
 1.06A 4iklA-5u4oA:
undetectable
4iklB-5u4oA:
undetectable		 4iklA-5u4oA:
15.61
4iklB-5u4oA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 TYR A 167
ARG A 469
SER A 168
 None
 1.20A 4lf7I-5u4oA:
undetectable
4lf7J-5u4oA:
undetectable		 4lf7I-5u4oA:
14.29
4lf7J-5u4oA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 TYR A 167
ARG A 469
SER A 168
 None
 1.20A 4lf8I-5u4oA:
undetectable
4lf8J-5u4oA:
undetectable		 4lf8I-5u4oA:
14.29
4lf8J-5u4oA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 11 ILE A 304
ALA A 303
GLN A 302
ALA A 484
VAL A 393
 None
 1.10A 4nqaA-5u4oA:
undetectable		 4nqaA-5u4oA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 LEU A 354
ASN A 348
ILE A 347
ASP A 346
 None
 0.67A 4rmjA-5u4oA:
undetectable		 4rmjA-5u4oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 SER A 172
TYR A  72
ALA A 422
SER A 510
LEU A 281
 None
 1.19A 4rrwB-5u4oA:
undetectable		 4rrwB-5u4oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 SER A 172
TYR A  72
ALA A 422
SER A 510
LEU A 281
 None
 1.19A 4rrzB-5u4oA:
undetectable		 4rrzB-5u4oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 4 ASN A 121
SER A 183
ALA A 124
VAL A 125
 None
 1.18A 4x1kC-5u4oA:
undetectable		 4x1kC-5u4oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 5 PHE A 288
PRO A 298
VAL A 300
ALA A 484
 None
 1.29A 4z4cA-5u4oA:
undetectable		 4z4cA-5u4oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ALA A  54
ARG A 514
GLU A 516
ARG A  50
 None
 0.80A 5bs8A-5u4oA:
4.4
5bs8B-5u4oA:
undetectable
5bs8C-5u4oA:
4.4		 5bs8A-5u4oA:
21.42
5bs8B-5u4oA:
21.35
5bs8C-5u4oA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 6 ALA A  54
ARG A 514
GLU A 516
ARG A  50
 None
 0.82A 5btgA-5u4oA:
4.8
5btgB-5u4oA:
undetectable
5btgC-5u4oA:
4.9		 5btgA-5u4oA:
21.42
5btgB-5u4oA:
21.35
5btgC-5u4oA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 11 PHE A 363
VAL A 300
ILE A 308
ILE A 382
ILE A 286
 None
 1.25A 5hw8B-5u4oA:
undetectable		 5hw8B-5u4oA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU A 275
LEU A 259
ASN A 258
ILE A 248
ILE A 245
 None
 1.01A 5mioB-5u4oA:
undetectable		 5mioB-5u4oA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 4 ASN A 121
SER A 183
ALA A 124
VAL A 125
 None
 0.91A 5nm5A-5u4oA:
undetectable		 5nm5A-5u4oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		6 / 12 ILE A 304
ALA A 305
ALA A 303
GLN A 302
ALA A 484
VAL A 393
 None
 1.34A 5uanA-5u4oA:
undetectable		 5uanA-5u4oA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 TRP A 506
ILE A 507
ASP A 508
 None
 0.87A 6i0y7-5u4oA:
undetectable		 6i0y7-5u4oA:
4.10