SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LS4_H_TCIH220_1 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT)	5u4r	VRC 315 53-1A09 FAB HEAVY CHAIN (Homo sapiens)	5 / 10	LEU A 37 TRP A 47 TYR A 58 GLY A 100 TRP A 103	None	1.32A	3ls4H-5u4rA: 26.7	3ls4H-5u4rA: 65.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5u4r	VRC 315 53-1A09 FAB HEAVY CHAIN (Homo sapiens)	4 / 6	TYR A 32 HIS A 33 VAL A 78 PHE A 27	None	0.91A	4a97E-5u4rA: undetectable	4a97E-5u4rA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5u4r	VRC 315 53-1A09 FAB HEAVY CHAIN (Homo sapiens)	4 / 7	TYR A 32 HIS A 33 VAL A 78 PHE A 27	None	0.97A	4a97H-5u4rA: undetectable	4a97H-5u4rA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	5u4r	VRC 315 53-1A09 FAB HEAVY CHAIN (Homo sapiens)	4 / 8	GLU A 81 GLU A 23 GLY A 8 SER A 7	None	1.01A	4f93B-5u4rA: undetectable	4f93B-5u4rA: 9.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LS4_H_TCIH220_1","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT","5u4r","VRC 315 53-1A09 FAB HEAVY CHAIN","Homo sapiens",5,"LEU A  37;TRP A  47;TYR A  58;GLY A 100;TRP A 103","None","1.32A","3ls4H-5u4rA:26.7","3ls4H-5u4rA:65.67"],["4A97_E_ZPCE1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","5u4r","VRC 315 53-1A09 FAB HEAVY CHAIN","Homo sapiens",4,"TYR A  32;HIS A  33;VAL A  78;PHE A  27","None","0.91A","4a97E-5u4rA:undetectable","4a97E-5u4rA:20.13"],["4A97_H_ZPCH1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","5u4r","VRC 315 53-1A09 FAB HEAVY CHAIN","Homo sapiens",4,"TYR A  32;HIS A  33;VAL A  78;PHE A  27","None","0.97A","4a97H-5u4rA:undetectable","4a97H-5u4rA:20.13"],["4F93_B_SANB3004_1","U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE","5u4r","VRC 315 53-1A09 FAB HEAVY CHAIN","Homo sapiens",4,"GLU A  81;GLU A  23;GLY A   8;SER A   7","None","1.01A","4f93B-5u4rA:undetectable","4f93B-5u4rA:9.00"]]