SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.14A 1p7lC-5u4sA:
undetectable		 1p7lC-5u4sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.13A 1p7lD-5u4sA:
undetectable		 1p7lD-5u4sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  12
ARG A  38
ASP A  56
ASN A  79
ALA A  80
 NAP  A 300 (-3.2A)
NAP  A 300 (-3.6A)
NAP  A 300 (-3.7A)
NAP  A 300 (-3.3A)
NAP  A 300 (-3.3A)
 1.02A 2bm9E-5u4sA:
6.6		 2bm9E-5u4sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  55
ILE A  57
PRO A 117
ILE A  73
VAL A 129
 None
NAP  A 300 (-4.1A)
None
None
NAP  A 300 (-4.8A)
 1.06A 2ygqA-5u4sA:
undetectable		 2ygqA-5u4sA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ILE A 126
ARG A  28
ALA A  24
LEU A  25
ALA A  30
 None
 1.23A 3lw5B-5u4sA:
undetectable		 3lw5B-5u4sA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 HIS A 231
LEU A 223
LEU A 138
LEU A 133
SER A 131
 None
PO4  A 302 ( 4.3A)
None
BEZ  A 301 (-4.2A)
BEZ  A 301 (-2.6A)
 1.46A 3q1eB-5u4sA:
undetectable
3q1eD-5u4sA:
undetectable		 3q1eB-5u4sA:
17.86
3q1eD-5u4sA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  26
GLY A  18
ILE A  77
ARG A  15
ALA A  13
 None
None
None
NAP  A 300 (-4.2A)
None
 1.28A 3uj7A-5u4sA:
5.5		 3uj7A-5u4sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  25
GLY A  18
GLY A  20
VAL A 196
ALA A  35
 None
 1.15A 4a6dA-5u4sA:
5.6		 4a6dA-5u4sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  25
LEU A  21
LEU A  17
ARG A  28
ILE A   3
 None
None
NAP  A 300 (-4.5A)
None
None
 1.26A 4f4dA-5u4sA:
undetectable		 4f4dA-5u4sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.10A 4kttA-5u4sA:
undetectable		 4kttA-5u4sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.15A 4ndnA-5u4sA:
undetectable		 4ndnA-5u4sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A   3
ALA A   8
VAL A 210
LEU A 203
LEU A  17
 None
None
None
None
NAP  A 300 (-4.5A)
 1.31A 4qynA-5u4sA:
undetectable		 4qynA-5u4sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.13A 5a1iA-5u4sA:
undetectable		 5a1iA-5u4sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ALA A   8
ILE A 126
ALA A 125
LEU A 119
 None
 0.65A 5te8B-5u4sA:
undetectable		 5te8B-5u4sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ALA A 134
ILE A 219
ALA A 220
LEU A 223
 None
None
None
PO4  A 302 ( 4.3A)
 0.69A 5te8B-5u4sA:
undetectable		 5te8B-5u4sA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		8 / 8 ASN A  83
SER A 131
ILE A 132
LEU A 133
MET A 141
LEU A 144
PRO A 176
MET A 215
 BEZ  A 301 (-4.0A)
BEZ  A 301 (-2.6A)
None
BEZ  A 301 (-4.2A)
BEZ  A 301 (-3.5A)
BEZ  A 301 (-4.9A)
BEZ  A 301 ( 4.0A)
BEZ  A 301 ( 4.1A)
 0.14A 5u4sB-5u4sA:
41.8		 5u4sB-5u4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A 165
PRO A 164
LYS A 120
SER A 116
 None
 1.12A 6fboA-5u4sA:
undetectable		 6fboA-5u4sA:
17.60