SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A 668
LEU A 700
LEU A 698
CYH A 658
 None
 1.04A 2ab2B-5u4vA:
undetectable		 2ab2B-5u4vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A 610
LEU A 632
VAL A 753
GLY A 752
 None
 0.95A 2po5A-5u4vA:
3.4		 2po5A-5u4vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 6 ILE A 678
CYH A 658
LEU A 721
ILE A 671
 None
 1.01A 2q83B-5u4vA:
undetectable		 2q83B-5u4vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A 601
GLY A 602
PHE A 670
PHE A 674
 None
 1.12A 3smtA-5u4vA:
undetectable		 3smtA-5u4vA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A 632
LEU A 750
ARG A 751
LEU A 754
 None
 0.78A 4wg0B-5u4vA:
undetectable
4wg0C-5u4vA:
undetectable		 4wg0B-5u4vA:
6.25
4wg0C-5u4vA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A 750
ARG A 751
LEU A 754
LEU A 632
 None
 0.69A 4wg0L-5u4vA:
undetectable
4wg0M-5u4vA:
undetectable		 4wg0L-5u4vA:
6.25
4wg0M-5u4vA:
6.25