SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		4 / 5 PHE A 117
LEU A  16
PHE A 113
SER A 191
 None
 1.28A 1wrkB-5u4zA:
undetectable		 1wrkB-5u4zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		4 / 8 ALA A  98
ALA A 101
ILE A  52
GLU A  49
 None
 0.81A 3dtuC-5u4zA:
undetectable
3dtuD-5u4zA:
undetectable		 3dtuC-5u4zA:
18.01
3dtuD-5u4zA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		4 / 7 LEU A 141
PHE A 192
LYS A  27
GLY A  28
 None
 1.06A 4hc3A-5u4zA:
undetectable		 4hc3A-5u4zA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		5 / 10 LEU A 145
LEU A 141
ALA A 144
LEU A  16
LEU A   9
 None
 1.06A 4p65A-5u4zA:
undetectable
4p65B-5u4zA:
undetectable
4p65F-5u4zA:
undetectable
4p65H-5u4zA:
undetectable		 4p65A-5u4zA:
5.70
4p65B-5u4zA:
7.94
4p65F-5u4zA:
7.94
4p65H-5u4zA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		5 / 11 LEU A 145
LEU A 141
ALA A 144
LEU A   9
LEU A  16
 None
 1.08A 4p65C-5u4zA:
undetectable
4p65D-5u4zA:
undetectable
4p65J-5u4zA:
undetectable
4p65L-5u4zA:
undetectable		 4p65C-5u4zA:
5.70
4p65D-5u4zA:
7.94
4p65J-5u4zA:
7.94
4p65L-5u4zA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		5 / 11 LEU A   9
LEU A  16
LEU A 145
LEU A 141
ALA A 144
 None
 1.14A 4p65B-5u4zA:
undetectable
4p65D-5u4zA:
undetectable
4p65G-5u4zA:
undetectable
4p65H-5u4zA:
undetectable		 4p65B-5u4zA:
7.94
4p65D-5u4zA:
7.94
4p65G-5u4zA:
5.70
4p65H-5u4zA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION
(Citrus
sinensis) 		5 / 12 LEU A   9
LEU A  16
LEU A 145
LEU A 141
ALA A 144
 None
 1.05A 4p65F-5u4zA:
undetectable
4p65H-5u4zA:
undetectable
4p65K-5u4zA:
undetectable
4p65L-5u4zA:
undetectable		 4p65F-5u4zA:
7.94
4p65H-5u4zA:
7.94
4p65K-5u4zA:
5.70
4p65L-5u4zA:
7.94