SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5u56 STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		5 / 12 ILE C  45
ILE C  42
ILE C  71
ALA C  18
THR C   9
 None
 1.18A 1jtxA-5u56C:
undetectable		 1jtxA-5u56C:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5u56 STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		4 / 7 PHE C 142
TYR C 179
LEU C 183
THR C 149
 None
 0.91A 1rmtB-5u56C:
undetectable		 1rmtB-5u56C:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5u56 STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		4 / 8 PHE C 142
TYR C 179
LEU C 183
THR C 149
 None
 0.90A 1rmtD-5u56C:
undetectable		 1rmtD-5u56C:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		5 / 12 LEU A  75
ALA A  26
LEU A   2
SER A  56
LEU A  55
 None
 1.20A 2c12C-5u56A:
undetectable		 2c12C-5u56A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		4 / 7 ILE A  94
ARG A  93
TYR C  59
GLU C  73
 None
 0.97A 2qebB-5u56A:
undetectable		 2qebB-5u56A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ARG A 142
GLU A 141
GLN A  88
PRO A  83
 GOL  A 302 ( 4.3A)
None
1PE  A 303 (-3.9A)
None
 1.48A 2qqtA-5u56A:
undetectable		 2qqtA-5u56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		4 / 4 VAL A  62
ARG C  88
ILE C 144
THR A  57
 None
 1.03A 3cl9A-5u56A:
undetectable		 3cl9A-5u56A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ARG A 142
GLU A 141
GLN A  88
PRO A  83
 GOL  A 302 ( 4.3A)
None
1PE  A 303 (-3.9A)
None
 1.45A 3gclA-5u56A:
undetectable		 3gclA-5u56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		3 / 3 LEU C 150
ARG A  89
ASN C  63
 None
 0.76A 3qxvD-5u56C:
undetectable		 3qxvD-5u56C:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 8 LEU A  55
THR A  54
PRO A  53
LEU A   2
 None
 1.14A 4qknA-5u56A:
2.8		 4qknA-5u56A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A
(Francisella
tularensis) 		5 / 10 LEU A  19
ILE A  68
ALA A  71
ILE A  72
ILE C  89
 None
 0.85A 5mvmD-5u56A:
3.1
5mvmE-5u56A:
2.7		 5mvmD-5u56A:
17.68
5mvmE-5u56A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ILE A  14
ILE A 187
LEU A 191
PHE A 196
 None
 1.07A 5vkqA-5u56A:
2.2
5vkqB-5u56A:
2.2		 5vkqA-5u56A:
8.28
5vkqB-5u56A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ILE A  14
ILE A 187
LEU A 191
PHE A 196
 None
 1.05A 5vkqA-5u56A:
2.2
5vkqD-5u56A:
undetectable		 5vkqA-5u56A:
8.28
5vkqD-5u56A:
8.28