SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.46A 1p7lD-5u5gA:
undetectable		 1p7lD-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.46A 1p7lC-5u5gA:
undetectable		 1p7lC-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.47A 1rg9B-5u5gA:
undetectable		 1rg9B-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.47A 1rg9A-5u5gA:
undetectable		 1rg9A-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.46A 1rg9D-5u5gA:
undetectable		 1rg9D-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 8 ALA A 169
GLU A 120
ASP A 117
ILE A 119
ILE A 149
 None
 1.46A 1rg9C-5u5gA:
undetectable		 1rg9C-5u5gA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 12 LEU A 172
GLY A 167
ILE A 138
HIS A 108
VAL A 163
 None
 1.36A 1tmxB-5u5gA:
undetectable		 1tmxB-5u5gA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 6 ILE A  17
ARG A  20
LEU A  21
LEU A 135
 None
 1.05A 2rlfA-5u5gA:
undetectable
2rlfD-5u5gA:
undetectable		 2rlfA-5u5gA:
9.69
2rlfD-5u5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 11 LEU A 152
LEU A  96
VAL A  94
CYH A 157
VAL A 139
 None
 1.12A 2uxoB-5u5gA:
1.5		 2uxoB-5u5gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 6 SER A 231
TYR A 224
VAL A 220
ASP A 278
 None
 1.23A 2x45A-5u5gA:
undetectable		 2x45A-5u5gA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 7 SER A 231
TYR A 224
VAL A 220
ASP A 278
 None
 1.22A 2x45B-5u5gA:
undetectable		 2x45B-5u5gA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 7 SER A 231
TYR A 224
VAL A 220
ASP A 278
 None
 1.25A 2x45C-5u5gA:
undetectable		 2x45C-5u5gA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 8 GLY A 115
ALA A 116
ASP A 117
THR A  56
 None
 0.48A 3el0A-5u5gA:
undetectable		 3el0A-5u5gA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 12 GLU A 144
VAL A 139
ASP A 117
ILE A 119
GLU A 120
 None
 1.48A 3jb3A-5u5gA:
undetectable		 3jb3A-5u5gA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 11 ILE A  17
GLY A  14
SER A 124
LEU A 135
ALA A 130
 None
None
7VD  A 302 (-2.7A)
None
None
 1.05A 3kw2A-5u5gA:
3.4		 3kw2A-5u5gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 11 ILE A  17
GLY A  14
SER A 124
LEU A 135
ALA A 130
 None
None
7VD  A 302 (-2.7A)
None
None
 1.07A 3kw2B-5u5gA:
3.2		 3kw2B-5u5gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 8 ASN A 177
VAL A 234
LEU A 243
TYR A 217
 7VD  A 302 (-3.3A)
NAP  A 301 (-4.1A)
None
7VD  A 302 (-4.4A)
 1.09A 4f5zA-5u5gA:
undetectable		 4f5zA-5u5gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 5 THR A 103
THR A  66
HIS A  31
LEU A  83
 None
NAP  A 301 (-4.3A)
None
None
 1.09A 5axaA-5u5gA:
9.8		 5axaA-5u5gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 5 THR A 103
THR A  66
HIS A  31
LEU A  83
 None
NAP  A 301 (-4.3A)
None
None
 1.09A 5axaC-5u5gA:
9.7		 5axaC-5u5gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 4 CYH A  18
LEU A  10
LEU A  41
ALA A  38
 None
 1.13A 5hpuA-5u5gA:
undetectable
5hpuB-5u5gA:
undetectable		 5hpuA-5u5gA:
9.09
5hpuB-5u5gA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		5 / 12 LEU A  62
LEU A  87
ARG A  60
HIS A 108
LEU A 107
 None
 1.21A 5toaB-5u5gA:
undetectable		 5toaB-5u5gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 6 GLY A  11
LEU A  10
VAL A 123
PHE A  63
 NAP  A 301 (-3.2A)
None
None
None
 0.97A 6h7lA-5u5gA:
undetectable		 6h7lA-5u5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Pseudomonas
syringae) 		4 / 6 GLY A  11
LEU A  10
VAL A 123
PHE A  63
 NAP  A 301 (-3.2A)
None
None
None
 0.96A 6h7lB-5u5gA:
undetectable		 6h7lB-5u5gA:
16.85